Results 91 to 100 of about 4,830,735 (205)

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes

, 2022
GATA binding protein 3 (Gata3), a zinc-finger transcription factor, plays an important role in neural development. However, its expression and bioactivity in the retina remain unclear.
Shuilian Chen, Xuan Liu, Jiejie Zhuang, Xi Chen, Anqi He, Zihua Jiang, Pei Chen, Keming Yu, Qian Luo, Jin Qiu, Ying Yang, Jing Zhuang, Yihui Wu, Qiyun Wang, Yan Li   +14 more
core   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

, 2013
GATA binding protein 3 (Gata3) is a GATA family transcription factor that controls differentiation of naïve CD4 T cells into T helper 2 (Th2) cells. However, it is unknown how Gata3 simultaneously activates Th2-specific genes while repressing those of ...
Tanaka, T., Tumes, D.J., Ohkubo, S., Onodera, A., Nakayama, T., Endo, Y., Kanai, A., Endoh, K., Kato, M., Suzuki, Y., Iwamura, C., Hosokawa, H., Sugano, S.   +12 more
core   +1 more source

PARP1 Modulates GATA3-Mediated Gene Regulation In Breast Cancer [PDF]

In eukaryotic cells, chromatin acts as a physical barrier for many transcription factors, preventing them from efficiently binding to their recognition sequences within the nucleosome.
Cooper, Mikhala
core   +1 more source

Tfam-mediated metabolic perturbation in RORγt+ lymphocytes impacts intestinal tissue homeostasis and promotes GATA3+RORγt+ innate lymphoid cells

Cell Reports
Summary: Rorc-mediated deletion of Tfam, a mitochondrial transcription factor, causes tuft cell and type 2 immunity-driven small intestine (SI) lengthening in mice. Here, we report an indispensable role for T helper 2 (Th2) cells in this process.
Na Sun, Rupam Paul, Eric Y. Helm, Zong-ming E. Chen, John W. Bostick, Liang Zhou   +5 more
doaj   +1 more source

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Molecular Cancer, 2008
Background The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor α (ERα) pathway.
Giguère Vincent, Wilson Brian J
doaj   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3

, 2011
Differentiation of naive CD4 T cells into Th2 cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes, including those encoding Th2 cytokines.
Tomoaki Tanaka, Shu Horiuchi, Atsushi Onodera, Toshinori Nakayama, Hiroyuki Hosokawa, Yukiko Watanabe, Sumio Sugano, Yutaka Suzuki   +7 more
core   +1 more source

Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment

, 2013
SummaryThe mechanisms underlying the silencing of alternative fate potentials in very early B cell precursors remain unclear. Using gain- and loss-of-function approaches together with a synthetic Zinc-finger polypeptide (6ZFP) engineered to prevent ...
Northrup, Daniel, Anupam Banerjee, Daniel Northrup, Jacobsen, Sten Erik W., Sten Erik W. Jacobsen, Banerjee, Anupam, Allman, David, Hanane Boukarabila, David Allman, Boukarabila, Hanane   +9 more
core   +2 more sources