Results 171 to 180 of about 4,830,735 (205)

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells [PDF]

Immunity, 2012
SummaryType 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling.
Cornelis M van Drunen, Julien J Karrich, Jenny Mjösberg   +2 more
exaly   +5 more sources

Functional Characterization of GATA3 Mutations Causing the Hypoparathyroidism-Deafness-Renal (HDR) Dysplasia Syndrome: Insight Into Mechanisms of DNA Binding by the GATA3 Transcription Factor [PDF]

Human Molecular Genetics, 2007
The hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome is an autosomal dominant disorder caused by mutations of the dual zinc finger transcription factor, GATA3. We investigated 21 HDR probands and 14 patients with isolated hypoparathyroidism for
Fiona Lalloo, Rajesh Thakker, Encarna Guillén Navarro   +2 more
exaly   +7 more sources

The TH1 Cell Lineage-Determining Transcription Factor T-Bet Suppresses TH2 Gene Expression by Redistributing GATA3 Away From TH2 Genes [PDF]

Nucleic Acids Research, 2022
Lineage-determining transcription factors (LD-TFs) drive the differentiation of progenitor cells into a specific lineage. In CD4+ T cells, T-bet dictates differentiation of the TH1 lineage, whereas GATA3 drives differentiation of the alternative TH2 ...
Richard G. Jenner, Robert Dagil, Paul R Barber   +2 more
exaly   +3 more sources

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells [PDF]

Immunity, 2020
Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF.
Gangqing Hu, Keji Zhao, Jinfang Zhu
exaly   +3 more sources

Pioneering New Enhancers by GATA3: Role of Facilitating Transcription Factors and Chromatin Remodeling

Nucleic Acids Research
Abstract Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessibility. However, mechanisms driving PTFs to specify collaborating transcription factor recruitment and chromatin remodeling remain unclear. Here, we utilize inducible expression of a PTF,
Krystal A Orlando, Paul A Wade, Sara A. Grimm   +2 more
exaly   +3 more sources

The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ [PDF]

Immunity, 2010
The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells. Here, we show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma.
Keji Zhao, Ryōji Yagi, Jinfang Zhu
exaly   +3 more sources