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The Transcription Factor GATA3 Positively Regulates NRP1 to Promote Radiation-Induced Pulmonary Fibrosis

International Journal of Biological Macromolecules
Radiation-Induced Pulmonary Fibrosis (RIPF) frequently arises as a delayed complication following radiation therapy for thoracic cancers, encompassing lung, breast, and esophageal malignancies. Characterized by a relentless and irreversible accumulation of extracellular matrix (ECM) proteins within the lung parenchyma, RIPF presents a significant ...
Duo Yu
exaly   +3 more sources

Transcription factor GATA3 and the human HDR syndrome.

Cellular and molecular life sciences : CMLS, 2001
Recently, a member of the GATA-binding family of transcription factors was shown to be involved in the human hypoparathyroidism, sensorineural deafness and renal anomalies (HDR) syndrome. Deletion-mapping studies and subsequent mutation analysis revealed that haploinsufficiency for GATA3 is the underlying mechanism of the HDR syndrome.
H, Van Esch, K, Devriendt
openaire   +1 more source

The asthma-COPD overlap syndrome: Transcription factors GATA3 and STAT6 as possible markers

European Respiratory Journal, 2014
The aim of the study is to analyze an expression of transcription factors (GATA3, STAT6, et al.) and IFN-γ in peripheral blood of patients with asthma-COPD overlap syndrome and asthma. Materials and methods. 24 patients with asthma and 18 with asthma-COPD overlap syndrome were examined.
Lada Sorokina   +6 more
openaire   +1 more source

The role of Pax2 and Gata3 transcription factors in urogenital system development and cancer.

2012
The complexity of its development makes the urogenital system vulnerable to a number of developmental defects, some of which are associated with a higher susceptibility to malignant transformation. Cancer, as a group of heterogenous disease, poses a serious challenge because of our limited understanding of normal cellular processes.
openaire   +1 more source

Transcriptional factors F???3,?-Maf, GATA3 and T-bet in different variants of bronchial asthma

Molecular Pathology and Functional Genomics, 2017
Predominance of Th-cells populations has been previously shown in patients with differtentvariants of bronchial asthma. To investigate cross-talk interactions between lymphocyte transcriptional factors Foxp3, c-Maf, GATA3 and T-bet we evaluated blood samples of 47 healthy volunteers and 82 patients with bronchial asthma. mRNA expression of Fохр3, с-Maf,
Anna Eremeeva   +4 more
openaire   +1 more source

Divergent lncRNA GATA3-AS1 Regulates GATA3 Transcription in T-Helper 2 Cells

Frontiers in Immunology, 2018
Laura C Kim   +2 more
exaly  

The mechanism of transcription factor GATA3 in esophageal squamous cell carcinoma

2nd Global Conference on Gynecology and Women's Health
openaire   +1 more source

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