Results 181 to 190 of about 4,830,735 (205)
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The Journal of Immunology, 2017
Abstract Long non-coding RNAs (lncRNAs) are RNAs transcribed by the genome, are >200 base pairs long, but are not translated into protein due to presence of multiple translational stop codons. LncRNAs possess a diverse array of regulatory functions including activation and silencing of gene transcription, regulation of splicing ...
Hunter Ramsdell Gibbons +2 more
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Abstract Long non-coding RNAs (lncRNAs) are RNAs transcribed by the genome, are >200 base pairs long, but are not translated into protein due to presence of multiple translational stop codons. LncRNAs possess a diverse array of regulatory functions including activation and silencing of gene transcription, regulation of splicing ...
Hunter Ramsdell Gibbons +2 more
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Expression of the transcription factor GATA3 in the postnatal mouse central nervous system
Neuroscience Research, 2008GATA binding protein 3 (GATA3) is an important regulator of central nervous system (CNS) development, but its expression pattern in the postnatal CNS has not been studied. In the present study, we examined the distribution of GATA3 mRNA in the mouse CNS at different postnatal stages by in situ hybridization.
Guang-Yu, Zhao +7 more
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Gastroenterology, 2017
GATA3 is a transcription factor that regulates T-cell production of cytokines. We investigated the role of GATA3 in development of colitis in mice.We performed quantitative polymerase chain reaction and immunofluorescence analyses of colon tissues from patients with Crohn's disease (n = 61) or ulcerative colitis (UC, n = 74) or from patients without ...
Benno Weigmann, Raja Atreya, Renz Harald
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GATA3 is a transcription factor that regulates T-cell production of cytokines. We investigated the role of GATA3 in development of colitis in mice.We performed quantitative polymerase chain reaction and immunofluorescence analyses of colon tissues from patients with Crohn's disease (n = 61) or ulcerative colitis (UC, n = 74) or from patients without ...
Benno Weigmann, Raja Atreya, Renz Harald
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Human Genome and Diseases: Review¶Transcription Factor GATA3 and the Human HDR Syndrome
Cellular and Molecular Life Sciences, 2001Koenraad Devriendt
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Journal of Comparative Neurology, 2009
AbstractDuring the development of the inner ear, auditory and vestibular ganglion neurons are generated in a highly regulated sequential process. First, neuroblasts are specified, delaminate from the epithelium of the otocyst, and migrate to form the auditory‐vestibular ganglion (AVG). These neuroblasts then undergo proliferation and differentiate into
Jennifer M, Jones, Mark E, Warchol
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AbstractDuring the development of the inner ear, auditory and vestibular ganglion neurons are generated in a highly regulated sequential process. First, neuroblasts are specified, delaminate from the epithelium of the otocyst, and migrate to form the auditory‐vestibular ganglion (AVG). These neuroblasts then undergo proliferation and differentiate into
Jennifer M, Jones, Mark E, Warchol
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Identification of the E3 Deubiquitinase Ubiquitin-Specific Peptidase 21 (USP21) as a Positive Regulator of the Transcription Factor GATA3 [PDF]
Journal of Biological Chemistry, 2013 The expression of the transcription factor GATA3 in FOXP3(+) regulatory T (Treg) cells is crucial for their physiological function in limiting inflammatory responses. Although other studies have shown how T cell receptor (TcR) signals induce the up-regulation of GATA3 expression in Treg cells, the underlying mechanism that maintains GATA3 expression in
Bin Li, Guochao Shi, Yayi Gao
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Oncogene, 2017
GATA3, a critical transcription factor involved in the development of the mammary gland, also plays important roles in mammary tumorigenesis by regulating transcription in coordination with two essential DNA repair factors, PARP1 and BRCA1. However, whether and how GATA3 participates in the process of DNA repair, which is often associated with ...
F, Zhang, H, Tang, Y, Jiang, Z, Mao
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GATA3, a critical transcription factor involved in the development of the mammary gland, also plays important roles in mammary tumorigenesis by regulating transcription in coordination with two essential DNA repair factors, PARP1 and BRCA1. However, whether and how GATA3 participates in the process of DNA repair, which is often associated with ...
F, Zhang, H, Tang, Y, Jiang, Z, Mao
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The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells [PDF]
Immunity, 2014 Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
Gangqing Hu, Keji Zhao, Ryōji Yagi
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Genome-Wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types [PDF]
Immunity, 2011 The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation. To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding sites in ten well-defined developmental and effector T lymphocyte lineages.
Keji Zhao, Gang Wei, Leelavati Narlikar
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Molecular Interactions of the Pioneer Transcription Factor
ABSTRACT The GATA3 transcription factor is a pioneer transcription factor that is critical in the development, proliferation, and maintenance of several immune cell types. Identifying the detailed conformational dynamics and interactions of this transcription factor, as well as its clinically important population variants will allow ...
Sowmomita Gharui, Durba Sengupta
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