Results 161 to 170 of about 37,179 (261)

Genomic characterization of pre‐Green Revolution wheat landraces from the Nepalese and Bhutanese Himalayas reveals geographically structured diversity

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Wheat (Triticum aestivum L.) landraces collected before the widespread regional adoption of Green Revolution cultivars provide a historical record of locally maintained germplasm. We characterized a panel of 202 accessions collected from Nepal and Bhutan between 1952 and 1958. Genotyping by Random Amplicon Sequencing‐Direct yielded 30,228 high‐
Li Yunfei, Meng Zhaojie, Miyuki Nitta, Atsushi Ohta, Kazuhiro Nemoto, Giri Prasad Joshi, Su Zhuo, Yasir Serag Alnor Gorafi, Shuhei Nasuda   +8 more
wiley   +1 more source

A Comprehensive Pipeline for the Use of Short Read Next-Generation Sequencing (SR-NGS) in <i>CYP21A2</i> Diagnostic Genotyping. [PDF]

Curr Issues Mol Biol
Fylaktou I, Tilemis FN, Mertzanian A, Kontse C, Makrythanasis P, Kanaka-Gantenbein C, Sertedaki A.   +6 more
europepmc   +1 more source

Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome

International Journal of Cancer, Volume 159, Issue 10, Page 2585-2594, 15 November 2026.
ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin, Dong Keon Kim, Yoojeong Seo, Hyeon Hee Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Jongwon Oh, Sanghoo Lee, Tae Il Kim   +10 more
wiley   +1 more source

Bridging the gap between legacy polymerase chain reaction-based microsatellite data with high-throughput sequencing data for conservation genomics. [PDF]

J Hered
Salih D, Armstrong EE, Robbins CT, Waits LP, Kelley JL.   +4 more
europepmc   +1 more source

Expanding the Utility of Exome Sequencing in Preventive and Population Genetics

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2433-2442, November 2026.
ABSTRACT Carrier screening is a long‐standing genetic testing process offered to at‐risk couples, with or without a family history, who might have pregnancies affected by an autosomal recessive (AR) or X‐linked (XL) disorder. A total of 276 unrelated individuals, initially referred for rare disorder screening by clinicians, were enrolled in this study ...
Charilaos Kostoulas, Athanasia Sesse, Ioanna Bouba, Robert Najdecki, Spyridon Konitsiotis, Sofia Markoula, Ioannis Georgiou   +6 more
wiley   +1 more source

Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study. [PDF]

Pathologica
Vitale D, Colarossi L, Russo G, Scimone C, Cozzolino D, De Luca C, Prjibelski AD, Mikheenko A, Colarossi C, Delli Muti F, Pepe F, Memeo L, Troncone G, Muscarella LA, Malapelle U.   +14 more
europepmc   +1 more source

HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Measurement of Disease Burden in Oropharyngeal Cancer

International Journal of Cancer, Volume 159, Issue 9, Page 2336-2346, 1 November 2026.
ABSTRACT The incidence of human papillomavirus‐positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly, and HPV early antigen serology has been proposed as a scalable and cost‐effective early detection test. HPV seropositivity can precede clinical presentation of OPC by several years, so additional surveillance procedures may be necessary to ...
Lucas Penny, Eric Yang Stutheit‐Zhao, Birgitta E. Michels, Fabian Rosing, Zhen Zhao, Yangqiao Zheng, Jinfeng Zou, Shao Hui Huang, Johnny Carlton, Andrew McPartlin, John R. de Almeida, David Goldstein, Andrew Hope, Ali Hosni, John Kim, Fei‐Fei Liu, C. Jillian Tsai, John N. Waldron, Anna Spreafico, Enrique Sanz‐Garcia, Lillian L. Siu, Tim Waterboer, Geoffrey Liu, Scott V. Bratman   +23 more
wiley   +1 more source

ProGenFixer: An Ultrafast and Accurate Tool for Correcting Prokaryotic Genome Sequences Using a Mapping-Free Algorithm. [PDF]

Comput Struct Biotechnol J
Song L, Wang M, Liao X, Wu J, Shi Z, Wang R, Li H, Liu L, He B, Ni X, Li Q, Li J, Ma H, Zheng P, Sun J, Ma Y.   +15 more
europepmc   +1 more source

Seascape genomics reveals high genetic diversity and apparent panmixia in endemic Southern Ocean phytoplankton

Limnology and Oceanography Letters, Volume 11, Issue 6, November 2026.
Abstract The adaptive potential and resilience of cold‐adapted phytoplankton to climate change have the potential to impact polar marine food webs and global biogeochemical cycles. Two central but poorly constrained facets of adaptive potential in polar phytoplankton are standing genetic diversity and its spatial structure. Here, we partially sequenced
Ian W. Bishop, Tatiana A. Rynearson
wiley   +1 more source

Comparison of variant callers using 60 532 multi-ancestry whole genome sequences. [PDF]

Brief Bioinform
Zhou H, Li Z, Shyr D, Li X, Yang H, Dey R, Tang Y, Maier R, Boerwinkle E, Buyske S, Daly M, Felsenfeld A, Gibbs RA, Gupta N, Hall IM, Matise T, Metcalf GA, Smith A, Reeves C, Sofia HJ, Stitziel NO, Zody MC, NHGRI Genome Sequencing Program (GSP) Consortium, Neale B, Lin X.   +24 more
europepmc   +1 more source