Results 11 to 20 of about 28,529 (123)

Paleoclimate evolution of the North Pacific Ocean during the late Quaternary: Progress and challenges

Geosystems and Geoenvironment, 2023
High- and low-latitude climatic processes in the North Pacific Ocean are important components of the global climate system. For example, the interplay among North Pacific atmospheric circulation, ocean circulation, and biological productivity affects ...
Yi Zhong, Zhengyao Lu, David J. Wilson, Debo Zhao, Yanguang Liu, Ting Chen, Congcong Gai, Xun Gong, Zhaoxia Jiang, Jiabo Liu, Qingsong Liu   +10 more
doaj   +1 more source

Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease

Journal of Translational Medicine, 2023
Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity.
H. Elsaid, M. Rivedal, E. Skandalou, E. Svarstad, C. Tøndel, E. Birkeland, Ø. Eikrem, J. Bábíčková, H. Marti, Jessica Furriol   +9 more
semanticscholar   +1 more source

Developing micro level resilience index for Indian Sundarban adopting resilience indicators for measurement and analysis (RIMA) methodology

Geosystems and Geoenvironment, 2023
Tropical cyclones induced multi-hazards have wreaked havoc on coastal communities in the last two-three years in coastal West Bengal, India. This research article aims to highlight the essence of these people's resilience to cyclone induced multi-scale ...
Manas Mondal, Anupam Biswas, Somnath Mandal, Subhasis Bhattacharya, Suman Paul   +4 more
doaj   +1 more source

Elucidating the toxic effect and disease mechanisms associated with Lyso-Gb3 in Fabry disease

Human Molecular Genetics, 2023
Fabry disease stems from a deficiency of alpha-galactosidase and results in the accumulation of globotriaosylceramide (Gb3). However, the production of its deacylated form globotriaosylsphingosine (lyso-Gb3) is also observed and its plasma levels have ...
V. Nikolaenko, D. Warnock, K. Mills, W. Heywood   +3 more
semanticscholar   +1 more source

Morphometric analysis of hillslope evolution in the Kadisha River Basin based on archived aerial photographs

Geosystems and Geoenvironment, 2023
The morphometric analysis of hillslope evolution, using the traditional method of interpreting archived aerial photographs, requires both considerable time and subjectivity.
Fabienne B. Youssef, Jean A. Doumit
doaj   +1 more source

GLA-modified RNA treatment lowers GB3 levels in iPSC-derived cardiomyocytes from Fabry-affected individuals

American Journal of Human Genetics, 2023
Summary Recent studies in non-human model systems have shown therapeutic potential of nucleoside-modified messenger RNA (modRNA) treatments for lysosomal storage diseases.
Menno ter Huurne, Benjamin L. Parker, Ning-Qing Liu, E. Qian, Céline J. Vivien, K. Karavendzas, R. Mills, J. Saville, Dad Abu-Bonsrah, Andrea F. Wise, James E. Hudson, A. Talbot, P. Finn, P. Martini, M. Fuller, S. Ricardo, K. Watt, Kathleen Nicholls, E. Porrello, D. Elliott   +19 more
semanticscholar   +1 more source

Clay mineralogy and provenance modeling of the Paleoproterozoic Kaladgi shales, Dharwar Craton, Southern India: Implications on paleoweathering and source rock compositions

Geosystems and Geoenvironment, 2023
Proterozoic clastic sediments reveal vast information regarding provenance, depositional conditions, and environmental evolutions. Peninsular India comprising Archean cratons, also have numerous intracratonic Proterozoic sedimentary basins along their ...
Pronoy Roy, G. Parthasarathy, Bulusu Sreenivas   +2 more
doaj   +1 more source

Development and testing a low-cost device for airborne PM monitoring in highly anthropized areas: The international maritime hub of Civitavecchia (Rome, Italy)

Geosystems and Geoenvironment, 2023
In this paper we describe our work aimed at designing a system able to measure the particulate matter (PM) concentrations via an optical particle counter (OPC) and simultaneously collect it via standard 2.5 cm filters for laboratory characterization. The
Federico Lucci, Giancarlo Della Ventura, Daniele Piazzolla, Carlo Venettacci, Andrea Terribili, Cecilia La Bella, Alessandra Conte, Simone Bonamano, Sergio Scanu, Francesco Radica, Marco Marcelli   +10 more
doaj   +1 more source

A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells

Cells, 2023
Aberrant glycosylation plays a crucial role in tumour progression and invasiveness. Tumour-associated carbohydrate antigens (TACAs) represent a valuable set of targets for immunotherapeutic approaches.
Jana Tomisch, Vincent Busse, Francesca Rosato, Olga N. Makshakova, Pavel Salavei, Anna-Sophia Kittel, É. Gillon, Levin Lataster, A. Imberty, A. V. Meléndez, W. Römer   +10 more
semanticscholar   +1 more source

Circulating Anti-GB3 Antibody as a Biomarker of Myocardial Inflammation in Patients with Fabry Disease Cardiomyopathy

Journal of Clinical Medicine, 2023
Background: Fabry disease cardiomyopathy (FDCM) has manifested some resistance to enzyme replacement therapy (ERT), particularly in its advanced phase. Recently, myocardial inflammation of autoimmune origin has been demonstrated in FDCM.
A. Frustaci, R. Verardo, M. Magnocavallo, Rossella Scialla, L. Sansone, M. Russo   +5 more
semanticscholar   +1 more source