Results 21 to 30 of about 28,529 (123)
Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells
Cellular and Molecular Life Sciences, 2022 The link between cancer and aberrant glycosylation has recently become evident. Glycans and their altered forms, known as tumour-associated carbohydrate antigens (TACAs), are diverse, complex and difficult to target therapeutically. Lectins are naturally
A. V. Meléndez +10 more
semanticscholar +1 more source
Lyso-Gb3 associates with adverse long-term outcome in patients with Fabry disease
Journal of Medical Genetics, 2021 Background Fabry disease (FD) is a rare X-linked lysosomal storage disease caused by mutations in the α-galactosidase A gene (GLA) leading to deficiency of α-galactosidase A and ultimately in progressive glycosphingolipid accumulation, especially ...
A. Nowak +4 more
semanticscholar +1 more source
Gb3/cd77 Is a Predictive Marker and Promising Therapeutic Target for Head and Neck Cancer
Biomedicines, 2022 Head and neck squamous cell carcinoma is the sixth leading cancer in the world. This cancer is difficult to treat and is characterized by recurrences that are often fatal.
L. García‐Hevia +6 more
semanticscholar +1 more source
High-Relaxivity Molecular MRI Contrast Agent to Target Gb3-Expressing Cancer Cells.
Bioconjugate chemistry, 2022 Targeted contrast agents (CAs) can improve magnetic resonance imaging (MRI) for accurate cancer diagnosis. In this work, we used the Shiga toxin B-subunit (STxB) as a targeting agent, which binds to Gb3, a glycosphingolipid highly overexpressed on the ...
S. Deville-Foillard +6 more
semanticscholar +1 more source
Chemistry, 2022 The plasma membrane is a complex assembly of proteins and lipids that can self‐assemble in submicroscopic domains commonly termed “lipid rafts”, which are implicated in membrane signaling and trafficking.
Larissa Socrier +5 more
semanticscholar +1 more source
Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3
Frontiers in Molecular Biosciences, 2021 Glycolipids are present on the surfaces of all living cells and thereby represent targets for many protein receptors, such as lectins. Understanding the interactions between lectins and glycolipids is essential for investigating the functions of lectins ...
Lina Siukstaite, A. Imberty, W. Römer
semanticscholar +1 more source
Journal of Biological Chemistry, 2021 The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually promiscuous glycosyltransferase. It synthesizes the Galα1→4Gal linkage on two different glycosphingolipids (GSLs), producing globotriaosylceramide (Gb3, CD77, Pk) and the P1 antigen.
Katarzyna Szymczak-Kulus +15 more
semanticscholar +1 more source
Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable
bioRxiv, 2021 N-glycosylation is a ubiquitous posttranslational modification that may influence folding, subcellular localization, secretion, solubility and oligomerization of proteins.
Krzysztof Mikołajczyk +13 more
semanticscholar +1 more source
Cellular and Molecular Life Sciences, 2021 The opportunistic pathogen Pseudomonas aeruginosa has gained precedence over the years due to its ability to develop resistance to existing antibiotics, thereby necessitating alternative strategies to understand and combat the bacterium.
Annette Brandel +12 more
semanticscholar +1 more source
Advancement of scienceCutaneous fibroblast heterogeneity is mechanistically linked to wound repair outcomes and fibrotic progression, with glycosphingolipid metabolism emerging as a critical determinant of physiological fibroblast diversity.
Su-Jie Xie +13 more
semanticscholar +1 more source