Results 31 to 40 of about 28,529 (123)

Quaternary surface development in the frontal Mikir massif, NE India: A possible key to understand the tectonic controls and geotechnical significance

Geosystems and Geoenvironment
Quaternary geological mapping has been carried out in the south-eastern frontal part of the Mikir massif in northeastern India. Geomorphological and surface geological studies have led to the delineation of three Quaternary surfaces viz., S1, S2, and S3,
Manash Protim Baruah, Devojit Bezbaruah, Tapos K. Goswami   +2 more
doaj   +1 more source

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research

Cellular & Molecular Biology Letters
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-α-d-galactosyltransferase, EC 2.4.1.228) forms Galα1 → 4Gal structures on glycosphingolipids and glycoproteins.
Katarzyna Szymczak-Kulus, M. Czerwinski, R. Kaczmarek   +2 more
semanticscholar   +1 more source

Determination of Gb3 and Lyso-Gb3 in Fabry Disease-Affected Patients by LC-MRM/MS

Separations
Limited or absent activity of the enzyme α-galactosidase A (α-Gal A), due to mutation in the related gene on the X chromosome, leads to the development of a rare hereditary and genetic disease known as Fabry disease (FD).
G. Battaglia, Gabriella Pinto, C. Fontanarosa, M. Spinelli, A. Illiano, S. Serpico, L. Chiariotti, R. Risoluti, S. Materazzi, A. Amoresano   +9 more
semanticscholar   +1 more source

Differential recognition of lipid domains by two Gb3-binding lectins

Scientific Reports, 2020
The two lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin from Shigella dysenteriae (StxB) share the glycosphingolipid globotriaosylceramide (Gb3) as receptor.
Thomas Schubert, Taras Sych, J. Madl, Mao-Kai Xu, Ramin Omidvar, Lukas J. Patalag, Annika Ries, K. Kettelhoit, Annette Brandel, Y. Mély, C. Steinem, D. Werz, Roland Thuenauer, W. Römer   +13 more
semanticscholar   +1 more source

Identification of GB3 as a Novel Biomarker of Tumor-Derived Vasculature in Neuroblastoma Using a Stiffness-Based Model

Cancers
Simple Summary Neuroblastoma (NB), a prevalent childhood cancer, presents challenges in treatment due to its cellular diversity and the presence of tumor-derived endothelial cells (TECs) associated with chemoresistance.
Aranzazu Villasante, Josep Corominas, C. Alcón, Andrea García-Lizarribar, J. Mora, Monica Lopez-Fanarraga, Josep Samitier   +6 more
semanticscholar   +1 more source

Gb3 trisaccharide-bearing exosomes as a novel neutralizer for Shiga toxin type 1

bioRxiv
Shiga toxin types 1 (Stx1) and 2 (Stx2), produced by Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae, are key virulence factors responsible for severe foodborne diseases, such as hemorrhagic colitis and hemolytic uremic syndrome ...
Krzysztof Mikołajczyk
semanticscholar   +1 more source

Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation

FASEB bioAdvances, 2020
Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs).
K. Roy, M. Uddin, S. Roy, R. A. Hill, J. Marshall, Yu-Teh Li, J. Chamcheu, Hua Lu, Yongyu Liu   +8 more
semanticscholar   +1 more source

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

bioRxiv, 2020
The opportunistic pathogen Pseudomonas aeruginosa is responsible for a high number of acute and chronic hospital-acquired infections. As it develops more and more resistances against existing antibiotics, P.
Annette Brandel, S. Aigal, S. Lagies, Manuel Schlimpert, Anika Lehmann, Daniel Hummel, Daniel Fisch, A. V. Meléndez, J. Madl, T. Eierhoff, B. Kammerer, W. Römer   +11 more
semanticscholar   +1 more source

Assessment of plasma lyso-Gb3 for clinical monitoring of treatment response in migalastat-treated patients with Fabry disease

Genetics in Medicine, 2020
Purpose To assess the utility of globotriaosylsphingosine (lyso-Gb 3 ) for clinical monitoring of treatment response in patients with Fabry disease receiving migalastat.
D. Bichet, J. Aerts, C. Auray-Blais, H. Maruyama, A. Mehta, N. Skuban, E. Krusinska, R. Schiffmann   +7 more
semanticscholar   +1 more source

Construction of ecological security pattern of Jiangnan water town considering water-related ecosystem services: a case study of Yuecheng District, Shaoxing

Geocarto International
The ecological security pattern (ESP) is considered an effective method to balance urban development and ecological protection. Integrating water-related ecosystem services (ESs) into the ESP construction process is essential for protecting urban water ...
Meizi Zhou, Yong He, Yonghua Li, Jialei Wang, Song Yao   +4 more
doaj   +1 more source