Results 31 to 40 of about 25,632 (110)

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research

Cellular & Molecular Biology Letters
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-α-d-galactosyltransferase, EC 2.4.1.228) forms Galα1 → 4Gal structures on glycosphingolipids and glycoproteins.
Katarzyna Szymczak-Kulus, M. Czerwinski, R. Kaczmarek   +2 more
semanticscholar   +1 more source

Determination of Gb3 and Lyso-Gb3 in Fabry Disease-Affected Patients by LC-MRM/MS

Separations
Limited or absent activity of the enzyme α-galactosidase A (α-Gal A), due to mutation in the related gene on the X chromosome, leads to the development of a rare hereditary and genetic disease known as Fabry disease (FD).
Gennaro Battaglia, Gabriella Pinto, Carolina Fontanarosa, M. Spinelli, A. Illiano, S. Serpico, Lorenzo Chiariotti, R. Risoluti, S. Materazzi, A. Amoresano   +9 more
semanticscholar   +1 more source

Differential recognition of lipid domains by two Gb3-binding lectins

Scientific Reports, 2020
The two lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin from Shigella dysenteriae (StxB) share the glycosphingolipid globotriaosylceramide (Gb3) as receptor.
Thomas Schubert, T. Sych, J. Madl, Maokai Xu, Ramin Omidvar, Lukas J. Patalag, Annika Ries, K. Kettelhoit, Annette Brandel, Y. Mély, C. Steinem, D. Werz, Roland Thuenauer, W. Römer   +13 more
semanticscholar   +1 more source

Identification of GB3 as a Novel Biomarker of Tumor-Derived Vasculature in Neuroblastoma Using a Stiffness-Based Model

Cancers
Simple Summary Neuroblastoma (NB), a prevalent childhood cancer, presents challenges in treatment due to its cellular diversity and the presence of tumor-derived endothelial cells (TECs) associated with chemoresistance.
Aranzazu Villasante, Josep Corominas, C. Alcón, Andrea García-Lizarribar, Jaume Mora, Monica Lopez-Fanarraga, Josep Samitier   +6 more
semanticscholar   +1 more source

Gb3 trisaccharide-bearing exosomes as a novel neutralizer for Shiga toxin type 1

bioRxiv
Shiga toxin types 1 (Stx1) and 2 (Stx2), produced by Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae, are key virulence factors responsible for severe foodborne diseases, such as hemorrhagic colitis and hemolytic uremic syndrome ...
Krzysztof Mikołajczyk
semanticscholar   +1 more source

Two Paralogous Gb3/CD77 Synthases in Birds Show Different Preferences for Their Glycoprotein and Glycosphingolipid Substrates

International Journal of Molecular Sciences, 2021
Most glycosyltransferases show remarkable gross and fine substrate specificity, which is reflected in the old one enzyme-one linkage paradigm. While human Gb3/CD77 synthase is a glycosyltransferase that synthesizes the Galα1→4Gal moiety mainly on ...
Anna Bereznicka, Krzysztof Mikołajczyk, Katarzyna Szymczak-Kulus, K. Kapczyńska, E. Majorczyk, Anna Modlińska, T. Piasecki, R. Kaczmarek, M. Czerwinski   +8 more
semanticscholar   +1 more source

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

bioRxiv, 2020
The opportunistic pathogen Pseudomonas aeruginosa is responsible for a high number of acute and chronic hospital-acquired infections. As it develops more and more resistances against existing antibiotics, P.
Annette Brandel, S. Aigal, S. Lagies, Manuel Schlimpert, A. Lehmann, Daniel Hummel, Daniel Fisch, A. V. Meléndez, J. Madl, T. Eierhoff, B. Kammerer, W. Römer   +11 more
semanticscholar   +1 more source

Analysis of the Ferry Service Network in Hong Kong

Island Studies Journal
Ferry transportation enhances urban mobility and connectivity across the Hong Kong region. This study analyses the ferry network in Hong Kong using social network analysis.
Yui-yip Lau, Maneerat Kanrak, Mark Ching-Pong Poo, Zhisen Yang, Zhuang Yang   +4 more
doaj   +1 more source

Litho-tectonostratigraphy of the Dhanjori Basin, India: A fold-thrust sequence and its tectonic relation with the Singhbhum Shear Zone

Geosystems and Geoenvironment
Based on direct field evidence, litho-tectonostratigraphy of the Neoarchaean-Palaeoproterozoic Dhanjori Basin, situated at the northeastern fringe of the Singhbhum Craton (SC), is being appraised for the first time.
Saptarshi Mallick, Arup Ratan Manna, Arun Kumar Kujur, J.P. Mohakul   +3 more
doaj   +1 more source

The Role of Air Transport Infrastructure Towards Breaking Seasonality in Emerging Tourism Destinations: A Qualitative Study of Akureyri, North Iceland

Island Studies Journal
This paper examines the impact of air infrastructure development on emerging insular destinations by focusing on Akureyri, located in North Iceland. It examines the intricate relationship between airport infrastructure capacity expansion, the building of
Carlos Pastor Chan Santana, Julie Madsen, Saverio Francesco Bertolucci   +2 more
doaj   +1 more source