Results 141 to 150 of about 25,057 (208)

Deletion of Gba in neurons, but not microglia, causes neurodegeneration in a Gaucher mouse model

JCI Insight
Gaucher disease, the most prevalent lysosomal storage disease, is caused by homozygous mutations at the GBA gene, which is responsible for encoding the enzyme glucocerebrosidase. Neuronopathic Gaucher disease is associated with microgliosis, astrogliosis,
Hannah B.D. Duffy, Colleen Byrnes, Hongling Zhu, Galina Tuymetova, Y. Terry Lee, Frances M. Platt, Richard L. Proia   +6 more
doaj   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2374-2380, October 2026.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2517-2525, October 2026.
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe, Sergio García‐Díaz, Laura Muñoz‐Delgado, Miguel Martín‐Bórnez, Silvia Jesús, Dolores Buiza‐Rueda, Marta Bonilla‐Toribio, Rafael Díaz‐Belloso, Daniel Macías‐García, Astrid Adarmes‐Gómez, Antonio Luque‐Ambrosiani, Rocío Pineda‐Sánchez, Lorena Clavijo‐Jiménez, Fátima Carrillo‐García, Pilar Gómez‐Garre, Pablo Mir   +15 more
wiley   +1 more source

Pro‐197 mutations confer resistance to thiencarbazone but not to foramsulfuron in ALS‐resistant Poa annua populations

Pest Management Science, Volume 82, Issue 10, Page 10134-10146, October 2026.
Foramsulfuron remains effective on Pro‐197 Poa annua, but co‐formulation with thiencarbazone reduces efficacy due to limited activity and antagonism. Therefore, foramsulfuron + thiencarbazone should be used in fields without ALS‐resistant weeds to ensure effective in‐crop control.
Vijaya Bhaskar Alwarnaidu Vijayarajan, Iniya Vijayakumar, Rafa Ruiz‐Partida, Fabian Runge, Joel Torra, Jorge Lozano‐Juste, Patrick Dermot Forristal   +6 more
wiley   +1 more source

Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan‐Containing Dipeptide Libraries

Journal of Peptide Science, Volume 32, Issue 10, October 2026.
Reversing the peptide backbone sequence of novel tryptophyl‐dipeptides uncovers profound changes in synthetic accessibility and antineoplastic profiles against human solid tumors. Phenotypic screening identifies a conformationally restricted lead architecture that achieves sub‐micromolar growth inhibition, confirming sequence topology as a critical ...
J. Benamer Díaz, Adam N. Khan, Aday González‐Bakker, José M. Padrón   +3 more
wiley   +1 more source

An Approximation Algorithm for Multi-Unit Auctions : Numerical and Subject Experiments

Operations Research and Decisions, 2018
In multi-unit auctions for a single item, the Vickrey-Clarke-Groves mechanism (VCG) attains allocative efficiency but suffers from its computational complexity. Takahashi and Shigeno thus proposed a greedy based approximation algorithm (GBA).
Satoshi Takahashi, Yoichi Izunaga, Naoki Watanabe   +2 more
doaj  

Upscaling Genotyping by Amplicon Sequencing With GBAS‐GUI

Molecular Ecology Resources, Volume 26, Issue 7, October 2026.
ABSTRACT Genotyping by amplicon sequencing (GBAS) is a relatively low‐cost approach for generating genotypic data compared with established genomic methods, making it highly scalable and particularly suitable for large‐scale genetic monitoring projects.
Sebastian Sonnenberg, Thapasya Vijayan, Christina Rupprecht, Yoko Philipina Krenn, Melissa Gruber, Hannah Dorfer, Gerald Kwikiriza, Harald Meimberg, Manuel Curto   +8 more
wiley   +1 more source

Long‐Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD)

Alcohol, Clinical and Experimental Research, Volume 50, Issue 10, October 2026.
This manuscript describes a 5‐year longitudinal follow‐up study of children with Fetal Alcohol Spectrum Disorders (FASD) who took part in one of three randomized controlled trials of choline supplementation when they were 2.5–5.9 years old. Results demonstrate that early choline supplementation improves long‐term non‐verbal IQ and working memory and ...
Jeffrey R. Wozniak, Judith K. Eckerle, Blake A. Gimbel, Abigail M. Ernst, Mary E. Anthony, Kent A. Tuominen, Erik de Water, Alexandra L. Doughty, Steven H. Zeisel, Michael K. Georgieff   +9 more
wiley   +1 more source

A latent class analysis of clinical complexity: Secondary analysis of the collaboration leading to addiction treatment and recovery from other stresses (CLARO) randomized trial

Addiction, Volume 121, Issue 10, Page 2833-2844, October 2026.
Abstract Background and aims Individuals with opioid use disorder (OUD) frequently present with co‐occurring mental health conditions such as depression and posttraumatic stress disorder (PTSD), along with other mental health substance use disorders, physical health conditions and social determinants that together comprise ‘clinical complexity ...
Megan S. Schuler, Rebecca Weir, Colleen M. McCullough, Grace M. Hindmarch, Beth Ann Griffin, Kirsten Becker, Lisa S. Meredith, Katherine E. Watkins   +7 more
wiley   +1 more source

Ambulante Versorgung des Ulcus cruris venosum in Deutschland: Eine retrospektive Analyse von Abrechnungsdaten

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 10, Page 1426-1434, October 2026.
Zusammenfassung Hintergrund und Zielsetzung Die ambulante Versorgung von Patienten mit Ulcus cruris venosum (UCV) ist aus medizinischer und gesundheitsökonomischer Perspektive hoch relevant. Häufig erfolgt die Behandlung uneinheitlich und nicht leitliniengerecht. Im Rahmen des GBA‐Innovationsfondsförderprojekts Ulcus Cruris Care (01VSF19043) sollte die
Lisa Weller, Regina Poß‐Doering, Thomas Grobe, Thomas Fleischhauer, Gunter Laux, Jona Frasch, Attila Altiner, Kerstin Protz, Joachim Szecsenyi, Jonas D. Senft   +9 more
wiley   +1 more source