Results 121 to 130 of about 25,057 (208)

Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis

Parkinson's Disease, 2015
GBA has been identified as a genetic risk factor for PD. Whether the clinical manifestations of PD patients with or without GBA mutations are different has still not reached a consensus.
Yuan Zhang, Qi-ying Sun, Yu-wen Zhao, Li Shu, Ji-feng Guo, Qian Xu, Xin-xiang Yan, Bei-sha Tang   +7 more
doaj   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, Volume 8, Issue 6, Page 2217-2234, November 2026.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Impact of GBA mutations in the outcomes of deep brain stimulation in Parkinson’s disease patients

, 2021
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021As mutações no gene da Glucocerebrosidase (GBA) são consideradas o fator de risco genético mais comum para o desenvolvimento de Doença de ...
Roque, Maria Marques
core  

GBA-Related Parkinson's Disease: Dissection of Genotype–Phenotype Correlates in a Large Italian Cohort

, 2020
Background: Variants in GBA are the most common genetic risk factor for Parkinson's disease (PD). The impact of different variants on the PD clinical spectrum is still unclear.
Colosimo C., Trezzi I., Bonifati V., Amboni M., ITA-GENE-PD Study Group., Fabbrini G., Pacchetti C., Altavista M. C., Bonanni L., Dati G., Pellecchia M. T., Ialongo T., Malaguti M. C., Stefani A., Avenali M., Bove F., Garbellini M., Di Fonzo A., Bonaventura C. D., Pisani A., Picillo M., Costanti D., Valente M. L., Barone P., Palmieri I., Onofrj M., Petrucci S., De Rosa A., Ginevrino M., Brusa L., Cogiamanian F., Cossu G., Fadda L., Erro R., Ardolino G., Sarchioto M., Thomas A., Eleopra R., Di Lazzaro V., Monfrini E., Bentivoglio A. R., Melis M., Ferrazzano G., Ricciardi L., Albanese A., Minafra B., Emanuele Elia A., Volpe G., Morgante F., Vallelunga A., Schirinzi T., Volpe G, Moro E., Peluso S., Criscuolo C., Petracca M., De Michele G., Oppo V., Romito L. M., Quadri M. L., Sorbera C., Cereda C., Guerra A., Ottaviani D., Zangaglia R., Valente E. M., Di Lazzaro G., Berardelli A.   +67 more
core   +1 more source

Male sex accelerates cognitive decline in GBA1 Parkinson’s disease

npj Parkinson's Disease
We evaluated 128 GBA and 432 nonGBA Parkinson’s disease (PD) subjects available from Parkinson’s Progression Markers Initiative. Baseline clinical features and dopaminergic activity were assessed, together with clinical follow-up (6.87 ± 3.2 years ...
Silvia Paola Caminiti, Micol Avenali, Alice Galli, Rachele Malito, Giada Cuconato, Caterina Galandra, Rosaria Calabrese, Andrea Pilotto, Alessandro Padovani, Fabio Blandini, Daniela Perani, Cristina Tassorelli, Enza Maria Valente   +12 more
doaj   +1 more source

Comparative analysis of methods for measuring glucocerebrosidase enzyme activity in patients with Parkinson’s disease with the GBA1 variant

Frontiers in Neurology
IntroductionGBA1 variants are significant genetic risk factors for Parkinson’s disease (PD). Accurately measuring glucocerebrosidase (GCase) activity is crucial for understanding disease progression and developing targeted therapies.
Jin Hwangbo, Myung Jun Lee, Myung Jun Lee, Sang Jin Kim, Hyun Kyung Park, Jae-Hyeok Lee, Jae-Hyeok Lee   +6 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Mn‐Substituted Topological Phase Transition in Topological Insulator Pt2HgSe3

Advanced Electronic Materials, Volume 12, Issue 19, 12 October 2026.
ABSTRACT Topological materials have gained a significant interest in recent years due to their unique features, leading to topological insulators (TI), Dirac or Weyl semimetals, etc. The layered material Pt2HgSe3${\rm Pt}_2{\rm HgSe}_3$ is found to be a dual TI characterized by significant spin–orbit coupling and band inversion.
Deergh Bahadur Shahi, Gang Bahadur Acharya, Dipak Bhattarai, Bishnu Karki, Madhav Prasad Ghimire   +4 more
wiley   +1 more source

Handleiding bij inspectie door de Gegevensbeschermingsautoriteit (GBA)

, 2019
Sinds 25 mei 2018 moet elke or­ganisatie de verplichtingen van de Algemene Verordening Gegevensbescherming (AVG)1 naleven. In België werd de Gegevensbeschermings­autoriteit (GBA) opgericht door de wet van 3 december 2017 tot oprichting van de ...
Bruyndonckx, Bastiaan, Plets, Isabel, Kuyken, Liese   +2 more
core  

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi, Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z. Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva‐Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C. L. Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R. Zimmer, Joseph Masdeu, Belen Pascual, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa‐Neto, for the HEAD Study, Cristiano S Aguzzoli, Livia Amaral, Guilherme Bauer‐Negrini, Bruna Bellaver, Ann D Cohen, Alvaro de Oliveira Franco, Douglas T Leffa, Pamela C L Ferreira, Firoza Z Lussier, Marina S Medeiros, Rayan Mroué, Markley S Oliveira, Tharick A Pascoal, Guilherme Povala, Andréia Rocha, Matheus S Rodrigues, Emma Ruppert, Pampa Saha, Juli Singer, Carolina Soares, Dana L Tudorascu, Raphael L Tuma, Suzanne L Baker, Cécile Tissot, Hsin‐Yeh Tsai, Pedro Rosa‐Neto, Tevy Chan, Vladimir Fonov, Yasser Iturria‐Medina, Wan Lu Jia, Jesse Klostranec, Maxime Montembault, Nesrine Rahmouni, Jenna Stevenson, Karine Provost, Paolo Vitali, Selma Avdagic, Emerine Cummings, Brian A Gordon, Danielle Gray, Victoria Tate, Joseph C Masdeu, Belen Pascual, Hwamee Oh, Xiaoyang Hu, Val Lowe, David N Soleimani‐Meigooni, Juan Fortea, Arthur Toga, Tatiana Foroud   +83 more
wiley   +1 more source