Results 111 to 120 of about 25,057 (208)

Dementia Caregivers' Preferences for Involvement in Delirium Care During Hospitalization

Journal of the American Geriatrics Society, EarlyView.
Family caregivers to hospitalized patients with dementia describe highly individual factors that affect how they navigate acute cognitive changes during illness and their preferences for involvement in delirium care. ABSTRACT Background Nearly half of hospitalized adults with dementia develop delirium superimposed on dementia (DSD), which is associated
Blair P. Golden, Brooke Johnson, Laura Block, Clark Benson, Kristin Merss, Kellia J. Hansmann, Gina Green‐Harris, Sharon K. Inouye, Andrea Gilmore‐Bykovskyi   +8 more
wiley   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Leakage‐Controlled Evaluation of Pixel‐Level MRI–sCT Fusion Reveals a Quality–Performance Mismatch in Brain Tumour Classification

Vector: The Journal of Engineering, Volume 2027, Issue 1, January/December 2027.
This study presents a leakage‐free evaluation of pixel‐level MRI–synthetic CT fusion for brain tumour classification using EfficientNet‐B0, image‐quality metrics, statistical testing and Grad‐CAM explainability. The results show that although fusion methods improved several image‐quality measures, none outperformed MRI‐only classification in accuracy ...
Muazzam Ali, Muhammad Usman Hashmi, Muhammad Azam, Raheem Sarwar   +3 more
wiley   +1 more source

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

ASEAN Four’s middle income trap dilemma: evidence of the middle technology trap

Asian Review of Political Economy
In Southeast Asia, Malaysia, Thailand, Indonesia and the Philippines are defined by the World Bank as countries that failed to overcome the "middle income trap". The four Southeast Asian countries (hereinafter referred to as the "ASEAN Four") entered the
Yian Ke
doaj   +1 more source

Expanding the Utility of Exome Sequencing in Preventive and Population Genetics

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2433-2442, November 2026.
ABSTRACT Carrier screening is a long‐standing genetic testing process offered to at‐risk couples, with or without a family history, who might have pregnancies affected by an autosomal recessive (AR) or X‐linked (XL) disorder. A total of 276 unrelated individuals, initially referred for rare disorder screening by clinicians, were enrolled in this study ...
Charilaos Kostoulas, Athanasia Sesse, Ioanna Bouba, Robert Najdecki, Spyridon Konitsiotis, Sofia Markoula, Ioannis Georgiou   +6 more
wiley   +1 more source

Structural Persistence and Topological Resilience of Maritime Corridors: A Case Study of the Intermediary Role of the Guangdong–Hong Kong–Macao Greater Bay Area

Mathematics
The Guangdong–Hong Kong–Macao Greater Bay Area (GBA) comprises the two Special Administrative Regions of Hong Kong and Macao, and the nine municipalities of Guangzhou, Shenzhen, Zhuhai, Foshan, Huizhou, Dongguan, Zhongshan, Jiangmen and Zhaoqing in ...
Huida Zhao, Yanan Yan
doaj   +1 more source

Glucocerebrosidase Mutations in Parkinson Disease

Journal of Parkinson’s Disease, 2017
Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) gene, which encodes a lysosomal enzyme involved in sphingolipid degradation ...
Grace O’Regan, Ruth-Mary deSouza, Roberta Balestrino, Anthony H. Schapira   +3 more
doaj   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Clinical prediction of GBA carrier status in Parkinson’s disease

Introduction: Given the unique natural history of GBA-related Parkinson’s disease (GBA-PD) and the potential for novel treatments in this population, genetic testing prioritization for the identification of GBA-PD patients is crucial for prognostication,
Giulietta M. Riboldi, Steven J. Frucht, Julia Greenberg, Kelly Astudillo, Adeen Flinker   +4 more
core   +1 more source