Results 131 to 140 of about 25,057 (208)

Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Cognitive impairment is a common non‐motor symptom of Parkinson's disease (PD), yet the mechanism remains unclear. METHODS Longitudinal serum samples from PD patients in a community‐based case–control study were profiled, with cognition assessed by the Mini‐Mental State Examination at baseline and follow‐up.
Yuyuan Lin, Yu Yu, Keren Zhang, Irish Del Rosario, Aline Duarte Folle, Elizabeth Rose Mayeda, Dean P. Jones, Douglas I. Walker, Jeff Bronstein, Adrienne M. Keener, Kimberly C. Paul, Beate Ritz   +11 more
wiley   +1 more source

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations

, 2018
Heterozygous mutations in GBA, the gene encoding the lysosomal enzyme glucosylceramidase beta/β-glucocerebrosidase, comprise the most common genetic risk factor for Parkinson disease (PD), but the mechanisms underlying this association remain unclear ...
Donghoon Kim (832917), Ottavio Arancio (53455), Sheng-Han Kuo (292031), Ellen Kanter (5702261), Guomei Tang (292032), Ahrom Ham (580182), Sergio Pablo Sardi (8200203), Hongyu Li (1332669), Thong Chi Ma (5702258), Han Seok Ko (8200200), David Sulzer (86849), Yi Quan (507988), Un Jung Kang (5702264), Aiqun Li (289891)   +13 more
core   +1 more source

Brains for dementia research at 18: Commitment to impact the value of human post‐mortem tissue

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The Brains for Dementia Research (BDR) project was established to provide high quality, neuropathologically characterized post‐mortem brain tissue from a cohort of participants longitudinally assessed for outcomes that are relevant for research in relation to dementia.
Keeley J. Brookes, Nicola Barnett, Johanna S. Jackson, Emma J Kidd, Debra J. Lett, Jillian Madine, Ben Middlehurst, Laura E. Palmer, Laura Parkkinen, Andrew C. Robinson, Rebecca Sims, Lindsey Sinclair, Alexandra Stolzing, Philip Tinkler, Claire Troakes, Lauren Walker, The BDR Collaborative, Alan Thomas, Patrick G. Kehoe   +18 more
wiley   +1 more source

Artificial Intelligence‐Driven Traffic Flow Forecasting and Spatial Road Operation Risk Assessment

Applied Research, Volume 5, Issue 5, October 2026.
The AGWN TF framework integrates adaptive graph‐based spatiotemporal forecasting with explicit temporal feature fusion for multistep traffic flow prediction and spatial road operation assessment. The framework improves forecasting performance, particularly at middle and longer prediction horizons, while the proposed Road Operation Risk Index converts ...
Yifei Zhu, Tongyao Jin, Hanzheng Sun
wiley   +1 more source

Whole‐Exome Sequencing Reveals the Genetic Landscape and Genotype–Phenotype Spectrum of Dystonia in a Chinese Cohort

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Whole‐exome sequencing of 147 Chinese patients with dystonia revealed an overall molecular diagnostic yield of 33.3%, with higher yields in generalized and childhood‐onset cases. The study expands the genotype–phenotype spectrum of established dystonia genes and provides population‐specific evidence to support genetic evaluation and molecular ...
Yiqing Gong, Huirong Peng, Zhao Chen, Jiawei He, Linliu Peng, Qian Jiang, Chunrong Wang, Linlin Wan, Lang He, Yuting Shi, Rong Qiu, Hong Jiang   +11 more
wiley   +1 more source

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Evaluation of the Efficacy of Photobiomodulation Therapy, Therapeutic Ultrasound, and Boric Acid in the Prevention of Intra‐Abdominal Adhesions in an Experimental Rat Model: A Macroscopic, Histopathological, and Gene Expression Analysis

Lasers in Surgery and Medicine, Volume 58, Issue 8, Page 656-671, October 2026.
ABSTRACT Objectives This study aimed to evaluate the efficacy of photobiomodulation therapy (PBMT), therapeutic ultrasound (TUS), boric acid (BA), and their combinations in preventing experimentally induced intra‐abdominal adhesions in rats. Materials and Methods Ninety‐six male Wistar rats (14 weeks old) were randomly assigned to eight groups (Control,
Sıtkıcan Okur, Büşra Baykal, Latif Emrah Yanmaz, Ayşe Gölgeli Bedir, Damla Tuğçe Okur, Mümin Gökhan Şenocak, Ferda Turgut, Serkan Yildirim, İsmail Bolat, Betül Apaydin Yildirim, Özlem Özdemir Tozlu   +10 more
wiley   +1 more source

Socio‐Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2546-2551, October 2026.
Abstract Background Socio‐occupational functioning in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN‐DBS) is not fully captured by standard motor and quality‐of‐life scales. Objectives To characterize patient‐reported socio‐occupational functioning after STN‐DBS and explore associated clinical and ...
Gabriele Imbalzano, Elisa Montanaro, Martina Giacchero, Claudia Ledda, Alberto Romagnolo, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti   +7 more
wiley   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2379-2394, October 2026.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Mechanistic insights into GBA deficiencies of the central nervous system

The GBA gene encodes the lysosomal enzyme glucocerebrosidase (GBA), which catabolises the glycosphingolipid glucosylceramide (GlcCer) into glucose and ceramide.

core   +1 more source