Results 91 to 100 of about 17,871 (218)
Civil Aviation High TECHNOLOGIES, 2018 The problem of accurate navigation support for landing systems is of great importance in our time in connection with the constantly increasing intensity of air traffic in major airports. At present, there is a trend towards a transition to navigational identification of aircraft by satellite radio navigation systems.
openaire +3 more sources
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Male sex accelerates cognitive decline in GBA1 Parkinson’s disease
npj Parkinson's DiseaseWe evaluated 128 GBA and 432 nonGBA Parkinson’s disease (PD) subjects available from Parkinson’s Progression Markers Initiative. Baseline clinical features and dopaminergic activity were assessed, together with clinical follow-up (6.87 ± 3.2 years ...
Silvia Paola Caminiti +12 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo +6 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, Volume 13, Issue 33, 15 June 2026.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan +18 more
wiley +1 more source
Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen +18 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.Fecal microbiota transplantation from patients with social anxiety disorder (SAD) into mice induces anxiety‐like behaviors, accompanied by gut microbiota alterations (increased Bacteroidota, decreased butyrate producers), downregulation of microbial metabolic pathways, and reduced plasma tryptophan, suggesting a causal role of gut dysbiosis in SAD ...
Yu‐Chao Feng +6 more
wiley +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source