Results 81 to 90 of about 18,064 (218)

Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis

Parkinson's Disease, 2015
GBA has been identified as a genetic risk factor for PD. Whether the clinical manifestations of PD patients with or without GBA mutations are different has still not reached a consensus.
Yuan Zhang, Qi-ying Sun, Yu-wen Zhao, Li Shu, Ji-feng Guo, Qian Xu, Xin-xiang Yan, Bei-sha Tang   +7 more
doaj   +1 more source

Macau as Method: Recombinant Urbanism in Post‐Socialist China

Asia Pacific Viewpoint, EarlyView.
ABSTRACT In ‘Asia as Method’, Chen Kuan‐Hsing argues for the value of an indigenous inter‐Asian approach to analysing the effects of European imperialism on the countries and citizens of Asia. This article mobilises both Chen's inter‐Asian referencing strategy and the city‐state of Macau to explore Macau's role in China's engagements with global ...
Tim Simpson
wiley   +1 more source

Defining Age to Screen and Real‐World Effectiveness for Early‐Onset Colorectal Cancer

Cancer Science, EarlyView.
Implementation of a RAP‐based risk‐adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50–54‐year age group.
Le Wang, Yu Qiu, Xuechen Chen, Weimiao Wu, Chen Zhu, Weiwei Chen, Tingting Pan, Dong Hang, Lingbin Du   +8 more
wiley   +1 more source

Glucocerebrosidase Mutations in Parkinson Disease

Journal of Parkinson’s Disease, 2017
Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) gene, which encodes a lysosomal enzyme involved in sphingolipid degradation ...
Grace O’Regan, Ruth-Mary deSouza, Roberta Balestrino, Anthony H. Schapira   +3 more
doaj   +1 more source

Patient treatment needs in atopic dermatitis: A real‐world cohort study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Among 697 adults with moderate‐to‐severe atopic dermatitis, itch relief was the leading treatment priority, whereas other needs differed by age, sex, education and disease onset. Patient‐reported outcomes tracked perceived benefit more closely than physician‐assessed severity, supporting systematic needs assessment to individualize care.
Kristina Ludemann, Stephan Traidl, Angela Cornelius, Joëlle Naim, Annice Heratizadeh, Tatjana Honstein, Barbara Kind, Luise Heinrich, Inken Harder, Dora Stölzl, Matthias Augustin, Thomas Schaefer, Anne Bong, Susanne Abraham, Andreas Pinter, Jutta Ramaker‐Brunke, Michael Schulz‐Kiesow, Sven Quist, Beate Schwarz, Tilo Biedermann, Mohammad Asefi, Caroline Mann, Nicole Adler, Michael Sticherling, Knut Schaekel, Anke Herrmann, Kathrin Meinhardt, Maren Stahl, Christiane Handrick, Sabine Anders, Stephan Weidinger, Jochen Schmitt, Thomas Werfel, the TREATgermany study group   +33 more
wiley   +1 more source

Dementia Caregivers' Preferences for Involvement in Delirium Care During Hospitalization

Journal of the American Geriatrics Society, EarlyView.
Family caregivers to hospitalized patients with dementia describe highly individual factors that affect how they navigate acute cognitive changes during illness and their preferences for involvement in delirium care. ABSTRACT Background Nearly half of hospitalized adults with dementia develop delirium superimposed on dementia (DSD), which is associated
Blair P. Golden, Brooke Johnson, Laura Block, Clark Benson, Kristin Merss, Kellia J. Hansmann, Gina Green‐Harris, Sharon K. Inouye, Andrea Gilmore‐Bykovskyi   +8 more
wiley   +1 more source

Effects of Graft Bending Angle on the Tensile Behavior of Bone Tunnel-Graft Constructs for Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon–Bone Graft

Bioengineering
Bone–patellar tendon–bone (BPTB) grafts used in anterior cruciate ligament reconstruction bend at the femoral tunnel aperture, forming a graft bending angle (GBA).
Satoshi Yamakawa, Konsei Shino, Tomoki Ohori, Ken Nakata   +3 more
doaj   +1 more source

Pathogenic GBA1 Variants and their Interaction with the Gut–Microbiota–Brain Axis in Parkinson's Disease

Movement Disorders, EarlyView.
Helen Dainton‐Howard, Phillip Engen, Kristi Lawrence, Maliha Shaikh, Mohamad Abdel‐Mohsen, Stefan Green, Ankur Naqib, Neha Joshi, Michelle Villanueva, Alana Kirby, Ali Keshavarzian, Christopher Goetz   +11 more
wiley   +1 more source

Time‐dependent laryngeal desensitisation following topical lidocaine and prilocaine application in cats: a randomised controlled study

Journal of Small Animal Practice, EarlyView.
Objectives To compare the effects of topical prilocaine and lidocaine, relative to topical 0.9% sodium chloride, on laryngeal reactivity in anaesthetised cats prior to endotracheal intubation. Materials and Methods In this prospective, randomised, controlled, double‐blind study, 24 healthy adult cats were enrolled and allocated to topical prilocaine ...
A. Gölgeli Bedir, L. E. Yanmaz, Y. Akçora, Ç. Özkalıpçı, Ö. T. Orhun, Y. Kocaman, S. Okur   +6 more
wiley   +1 more source

A combined artificial intelligence–wet lab approach identifies a pivotal role of the NAD+–mitophagy axis on aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Emerging evidence points to a role of nicotinamide mononucleotide (NAD+) depletion and compromised mitophagy in aging and neurodegenerative diseases. We hypothesize that age‐dependent impairment of the NAD+–mitophagy axis contributes to brain aging and neurodegeneration.
Sofie Lautrup, Shu‐qin Cao, Xi Long, Bonnie Hei Man Liu, Beatriz Escobar‐Doncel, Aristide Ferrante, Johannes Frank, Tomas Schmauck‐Medina, Geoffrey Ho Duen Leung, Kristina Xiao Liang, Ning Lu, Katerina Veverova, Martin Vyhnalek, Frank W. Pun, Alex Zhavoronkov, Evandro Fei Fang   +15 more
wiley   +1 more source