Results 81 to 90 of about 25,057 (208)

Gambogic acid inhibits LPS-induced macrophage pro-inflammatory cytokine production mainly through suppression of the p38 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): In traditional Chinese medicine, gamboge can detoxify bodies, kill parasites, and act as a hemostatic agent. Recent studies have demonstrated that gambogic acid (GBA) suppressed inflammation in arthritis, and also presented antitumor effect.
Ma Jianjun, Kangmao Huang, Yan Ma, Shuai Chen, Chao Liu, Zhi Shan, Xiangqian Fang   +6 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Comparison of gait parameters for the most and least affected sides in the in PD-GBA and non-GBA in the OFF-medication condition and healthy controls.

, 2020
Comparison of gait parameters for the most and least affected sides in the in PD-GBA and non-GBA in the OFF-medication condition and healthy controls.
Joan A. O’Keefe (8259825), Nicolette Purcell (8357199), Bichun Ouyang (6754522), Samantha Ruehl (8357190), Gian Pal (8357202), Mark Buder (8357193), Jessica Joyce (8357196), Anjali Gera (8357187), Yuanqing Liu (247712)   +8 more
core   +1 more source

Use of a biphasic perfusion process based on mild hypothermia for recombinant glucocerebrosidase (GBA) production [PDF]

, 2017
The main goal of this study was to develop an innovative CHO-based process for the production of glucocerebrosidase (GBA), an enzyme used for the replacement therapy of Type 1 Gaucher disease.
Coronel, Juliana, Gonçalves, Filipa M., Castilho, Leda R.   +2 more
core   +3 more sources

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Patients’ experiences of Parkinson’s disease: a qualitative study in glucocerebrosidase and idiopathic Parkinson’s disease

Journal of Patient-Reported Outcomes, 2020
Background Approximately 7–10% of Parkinson’s disease (PD) patients carry a GBA (Glucocerebrosidase) mutation (GBA-PD patients), which may influence the disease’s clinical course.
N. Bonner, S. Bozzi, L. Morgan, B. Mason, M. J. Peterschmitt, T. Z. Fischer, R. Arbuckle, M. Reaney   +7 more
doaj   +1 more source

Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants

npj Parkinson's Disease
Parkinson’s Disease (PD) patients carrying GBA1-variants (GBA-PD) often show a faster cognitive decline, suggesting accelerated cholinergic degeneration.
Sofie Slingerland, Eline K. R. de Meyer, Harm J. van der Horn, Giulia Carli, Anne C. Slomp, Emile d’Angremont, Jeffrey M. Boertien, Ingeborg Goethals, Sanne K. Meles, Sygrid van der Zee, Teus van Laar   +10 more
doaj   +1 more source

Disease‐Duration–Specific Percentiles for Prospective Subtyping of Parkinson's Disease: A PPMI‐Based Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is clinically heterogeneous, with variable progression rates that complicate clinical trial design. The data‐driven diffuse malignant (DM), intermediate (IM), and mild‐motor predominant (MMP) subtyping model has prognostic value but lacks disease duration–specific thresholds for prospective use in disease ...
Ahmed Negida, Nitai Mukhopadhyay, Brian D. Berman, Seyed‐Mohammad Fereshtehnejad, Matthew J. Barrett   +4 more
wiley   +1 more source

GBA alignment

, 2013
Ninety-two samples of sequence data from the GBA gene across jumping mice including N. insignis (5 subspecies), Z. hudsonius (12 subspecies), Z. princeps (10 subspecies), and Z. trinotatus (4 subspecies)
Malaney, Jason L., Joseph A. Cook (222141), Cook, Joseph A., Jason L. Malaney (3297975)   +3 more
core   +1 more source

Distinctive cognitive phenotypes in Parkinson’s disease patients with GBA mutations and without dementia: a multicentre cross-sectional retrospective study

Clinical Parkinsonism & Related Disorders
Background: Cognitive impairment is a major non-motor complication of Parkinson’s disease (PD). GBA mutations are associated with an increased risk, with PD-GBA+ patients typically showing earlier disease onset and faster cognitive decline.
Chiara Longo, Marco Liccari, Ruggero Bacchin, Costanza Papagno, Donatella Ottaviani, Raffaella Di Giacopo, Mauro Catalan, Alina Menichelli, Massimo Marano, Alessio Di Fonzo, Giovanni Duro, Carmela Zizzo, Paolo Manganotti, Bruno Giometto, Maria Chiara Malaguti   +14 more
doaj   +1 more source