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Results 101 to 110 of about 18,064 (218)

Deletion of Gba in neurons, but not microglia, causes neurodegeneration in a Gaucher mouse model

JCI Insight
Gaucher disease, the most prevalent lysosomal storage disease, is caused by homozygous mutations at the GBA gene, which is responsible for encoding the enzyme glucocerebrosidase. Neuronopathic Gaucher disease is associated with microgliosis, astrogliosis,
Hannah B.D. Duffy +6 more
doaj +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon +6 more
wiley +1 more source

Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α‐Synuclein and Mediation of Age Effects

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1861-1875, August 2026.
Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham +8 more
wiley +1 more source

GBA Gene [PDF]

, 2020
openaire +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source

An Approximation Algorithm for Multi-Unit Auctions : Numerical and Subject Experiments

Operations Research and Decisions, 2018
In multi-unit auctions for a single item, the Vickrey-Clarke-Groves mechanism (VCG) attains allocative efficiency but suffers from its computational complexity. Takahashi and Shigeno thus proposed a greedy based approximation algorithm (GBA).
Satoshi Takahashi, Yoichi Izunaga, Naoki Watanabe +2 more
doaj

Predictive Models for Motor Outcomes From Deep Brain Stimulation in Parkinson's Disease: A Systematic Review

European Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Our systematic search uncovered 19 studies creating predictive models of motor outcomes from deep brain stimulation for Parkinson's disease. We review prediction accuracy and replicability and discuss candidate input data and the presentation of predictions.
Maya Wilde +4 more
wiley +1 more source

Glucocerebrosidase (GBA; GCase) [PDF]

Science-Business eXchange, 2011
openaire +2 more sources

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

HIV Medicine, Volume 27, Issue 8, Page 1312-1332, August 2026.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria +555 more
wiley +1 more source

The Role of Language Dominance in Congruency Effects on Multi‐Word Unit Processing: Evidence From Early Bilinguals

International Journal of Applied Linguistics, Volume 36, Issue 3, Page 2808-2821, August 2026.
ABSTRACT This study investigates how the learner‐related factors of language dominance, encompassing language history, proficiency, use, and attitude, modulate congruency effects in multi‐word unit (MWU) processing among early bilinguals. Seventy Cantonese–Putonghua bilinguals completed lexical decision tasks measuring reaction time and accuracy for ...
Mingjia Cai, Yuan Liang
wiley +1 more source

parkinson’s disease
neurology
diseases of the nervous system

parkinson's disease
medicine
glucocerebrosidase