Results 101 to 110 of about 17,871 (218)

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Hydroxy‐α‐Sanshools From Zanthoxylum bungeanum Maxim. Alleviate Obesity in Mice via the Regulation of Appetite and Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Hydroxy‐alpha‐sanshool could modulate the expression of appetite‐related factors and the composition of intestinal microbiota in mice fed with a high‐fat diet by regulating food intake and maintaining energy homeostasis, which is consistent with the involvement of the gut‐brain axis in this regulatory mechanism.
Tianting Luo, Yuping Zhu, Fangyan Xu, Jiao Xie, Huifang Chen, Likang Qin, Tingyuan Ren   +6 more
wiley   +1 more source

Deletion of Gba in neurons, but not microglia, causes neurodegeneration in a Gaucher mouse model

JCI Insight
Gaucher disease, the most prevalent lysosomal storage disease, is caused by homozygous mutations at the GBA gene, which is responsible for encoding the enzyme glucocerebrosidase. Neuronopathic Gaucher disease is associated with microgliosis, astrogliosis,
Hannah B.D. Duffy, Colleen Byrnes, Hongling Zhu, Galina Tuymetova, Y. Terry Lee, Frances M. Platt, Richard L. Proia   +6 more
doaj   +1 more source

An Approximation Algorithm for Multi-Unit Auctions : Numerical and Subject Experiments

Operations Research and Decisions, 2018
In multi-unit auctions for a single item, the Vickrey-Clarke-Groves mechanism (VCG) attains allocative efficiency but suffers from its computational complexity. Takahashi and Shigeno thus proposed a greedy based approximation algorithm (GBA).
Satoshi Takahashi, Yoichi Izunaga, Naoki Watanabe   +2 more
doaj  

GBA Gene [PDF]

, 2020
openaire   +1 more source

Mutational dynamics in patients with del(5q) MDS treated with lenalidomide prior to transfusion dependency—Molecular results from the Sintrarev clinical trial

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Lenalidomide (Len) is the standard of care for red blood cell transfusion‐dependent (TD) patients with myelodysplastic syndromes (MDS) and del(5q). A Phase III clinical trial (SintraRev) demonstrated better efficacy of early treatment with Len in anemic del(5q) MDS patients prior to TD, but clonal evolution with this approach remained ...
Sofía Toribio Castelló, Felix López‐Cadenas, Claude Preudhomme, Teresa González, Angela Villaverde Ramiro, Laurène Fenwarth, Blanca Xicoy, Aline Renneville, Joaquín Sánchez‐Garcia, Rosa Coll, Bohrane Slama, José Ángel Hernández‐Rivas, Sylvain Thepot, Teresa Bernal, Agnès Guerci‐Bresler, Raúl Azibeiro, Monica Del Rey, Katharina S. Götze, Pierre Fenaux, Jesús María Hernández‐Rivas, María Díez‐Campelo   +20 more
wiley   +1 more source

The Power of Land: Structure and Function Transitions Steering China's Sustainable Development Goal Pathways

Earth's Future, Volume 14, Issue 6, June 2026.
Abstract In the context of the 2030 Agenda for Sustainable Development Goal (SDG) entering its final critical window, it is essential that a more forward‐looking urban land‐management system be constructed, as land space constitute the core spatial carriers of the SDGs.
Guoen Wei, Zixuan Rao, Ruzi Li, Changjia Li, Xiao Ouyang, Tongning Li, Shuoshuo Li, Xi Tian, Christopher Lyon, Weifeng Deng, Longwu Liang, Yiting Yang, Kang Luo, Yaobin Liu, Chuanglin Fang   +14 more
wiley   +1 more source

Glucocerebrosidase (GBA; GCase) [PDF]

Science-Business eXchange, 2011
openaire   +2 more sources

Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Freezing of gait (FoG) occurs across Parkinson's disease, multiple neurodegenerative conditions and non‐neurodegenerative disorders. This review synthesizes the structural, neurochemical and proteinopathic substrates underlying FoG, showing how cumulative damage to distributed locomotor circuits—compounded by overlapping pathologies—progressively ...
Gabor G. Kovacs
wiley   +1 more source

Missed opportunities to prevent HIV acquisition with pre‐exposure prophylaxis: A mixed methods study of people with recently acquired HIV in the United Kingdom

HIV Medicine, Volume 27, Issue 6, Page 979-990, June 2026.
Abstract Objectives To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom. Methods Data were derived from CASCADE, an international, longitudinal, mixed‐methods study of adults (≥16 years) with recently acquired HIV (≤12 months).
Argyro Karakosta, Emily Jay Nicholls, Flavien Coukan, Diarmuid Nugent, Iain Reeves, Laura Waters, Sarah Fidler, Elisa Ruiz Burga, Julie Fox, Alison Uriel, Jane Nicholls, Claire Mackintosh, Shema Tariq, Fiona Burns, for CASCADE Collaboration, John Gill, Kholoud Porter, Fiona Burns, Christina Carlander, Rafael Eduardo Campo, Harmony Garges, Sophie Grabar, Inma Jarrín, Laurence Meyer, Moustafa Kamel, Shema Tariq, Giota Touloumi, Marc van der Valk, Vani Vannappagari, Alain Volny Anne, Linda Wittkop, Lital Young, Agnes Aisam, Diana Barger, Eli Fitzgerald, Argyro Karakosta, Emily Jay Nicholls, Nicoletta Policek, Bruno Spire, Inés Suárez‐García, Sophie Abgrall, Valerie Andriantsoanirina, Veronique Avettand‐Fenoel, Christine Bourgeois, Marie‐Laure Chaix, Antoine Cheret, Hugues Fischer, Cecile Goujard, Caroline Lascoux‐Combe, Annie Le Palec, Ventzlislava Petrov‐Sanchez, Asier Saez‐Cirion, Remonie Seng, Karl Stefic, Josephine Tine, E Piet, A Gagneux‐Brunon, C Jacomet, L Piroth, F Benezit, M Goussef, P Tattevin, F Bani Sadr, I Lamaury, M Nacher, H Bazus, O Robineau, R Calin, C Katlama, JL Meynard, B Denis, J Ghosn, V Joly, MA Khuong, F Caby, E Rouveix Nordon, P de Truchis, S Abgrall, A Chéret, C Duvivier, A Becker, P Miailhes, S Abel, G Unal, A Makinson, G Martin‐Blondel, A Morisot, S Bregigeon, C Allavena, V Rabier, H Fischer, L Vallet, L Marchand, T Saïdi, D Costagliola, S Grabar, Pierre Tattevin, Pierre de Truchis, M Hughes Fischer, Santiago Moreno, David Dalmau, M Luisa Navarro, M Isabel González, Federico Garcia, Eva Poveda, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M Ángeles Muñoz‐Fernández, G. Adamis, M. Chini, G. Chrysos, M. Marangos, O. Katsarou, D. Kofteridis, S. Metallidis, P. Panagopoulos, N. Pantazis, A. Papadopoulos, V. Paparizos, V. Papastamopoulos, M. Psychogiou, H. Sambatakou, NV. Sipsas, G. Touloumi, C Thomadakis, Julie Fox, Louise Terry, Alison Uriel, Sarah Fidler, Wilbert Ayap, Laura Waters, Fowsiya Nur, Sabine Kinloch, Thomas Fernandez, Diarmuid Nugent, Javier Pinedo, Iain Reeves, Lidia Ignatov, Tracy Fong, Laura Cunningham, Jaydee Pangan, Claire Mackintosh, Louise Sharp   +145 more
wiley   +1 more source