Results 101 to 110 of about 25,057 (208)

Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker‐Positive, Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co‐occur. Their long‐term evolution remains incompletely characterized, particularly in biomarker‐positive cohorts.
Izabelle Schoen, Jing Wang, Sharon X. Xie, Chelsea Caspell‐Garcia, Eugenia Mamikonyan, Melanie Stark, Nabila Dahodwala, Andrew D. Siderowf, Roseanne Dobkin, Michele K. York, Daniel Weintraub   +10 more
wiley   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Localization of Active Endogenous and Exogenous GBA by Correlative Light-Electron Microscopy in Human Fibroblasts [PDF]

, 2019
β-Glucocerebrosidase (GBA) is the enzyme that degrades glucosylceramide in lysosomes. Defects in GBA that result in overall loss of enzymatic activity give rise to the lysosomal storage disorder Gaucher disease, which is characterized by the accumulation
Lienden, M.J.C. van der, Overkleeft, H.S., Meel, E. van, Bos, E., Kasteren, S.I. van, Aerts, J.M.F.G., Koster, A.J.   +6 more
core   +1 more source

‘Sustainable Development’ or ‘Development Sustainability’? A Corpus Linguistic Analysis of Hong Kong Legislative Discourse (2016–2021)

Sustainable Development, EarlyView.
ABSTRACT Grounded in the Sustainable Development Goals (SDGs) framework, I examined sustainability discourse in the Hong Kong Legislative Council (LegCo) Hansards. Using LancsBox X, I employed collocational and concordance analyses to investigate a 15.7‐million‐word Hansard corpus.
Emmanuel Mensah Bonsu
wiley   +1 more source

Macau as Method: Recombinant Urbanism in Post‐Socialist China

Asia Pacific Viewpoint, EarlyView.
ABSTRACT In ‘Asia as Method’, Chen Kuan‐Hsing argues for the value of an indigenous inter‐Asian approach to analysing the effects of European imperialism on the countries and citizens of Asia. This article mobilises both Chen's inter‐Asian referencing strategy and the city‐state of Macau to explore Macau's role in China's engagements with global ...
Tim Simpson
wiley   +1 more source

Dual-Task Performance in GBA Parkinson’s Disease [PDF]

, 2017
Introduction. Parkinson’s disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson’s disease (iPD) patients, but the mechanisms behind this observation are
Markus A. Hobert, Hobert, Markus A., Maetzler, Walter, Ann-Kathrin Hauser, Thomas Gasser, Walter Maetzler, Ogbamicael, Senait, Berg, Daniela Dagmar Denise, Daniela Berg, Brockmann, Kathrin, Karin Srulijes, Michael Schwenk, Kathrin Brockmann, Senait Ogbamicael, Jasmin Fritzen, Mätzler, Walter, Hauser, Ann-Kathrin, Fritzen, Jasmin, Schulte, Claudia, Gasser, Thomas, Srulijes, Karin, Claudia Schulte, Schwenk, Michael   +22 more
core   +1 more source

Defining Age to Screen and Real‐World Effectiveness for Early‐Onset Colorectal Cancer

Cancer Science, EarlyView.
Implementation of a RAP‐based risk‐adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50–54‐year age group.
Le Wang, Yu Qiu, Xuechen Chen, Weimiao Wu, Chen Zhu, Weiwei Chen, Tingting Pan, Dong Hang, Lingbin Du   +8 more
wiley   +1 more source

Patient treatment needs in atopic dermatitis: A real‐world cohort study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Among 697 adults with moderate‐to‐severe atopic dermatitis, itch relief was the leading treatment priority, whereas other needs differed by age, sex, education and disease onset. Patient‐reported outcomes tracked perceived benefit more closely than physician‐assessed severity, supporting systematic needs assessment to individualize care.
Kristina Ludemann, Stephan Traidl, Angela Cornelius, Joëlle Naim, Annice Heratizadeh, Tatjana Honstein, Barbara Kind, Luise Heinrich, Inken Harder, Dora Stölzl, Matthias Augustin, Thomas Schaefer, Anne Bong, Susanne Abraham, Andreas Pinter, Jutta Ramaker‐Brunke, Michael Schulz‐Kiesow, Sven Quist, Beate Schwarz, Tilo Biedermann, Mohammad Asefi, Caroline Mann, Nicole Adler, Michael Sticherling, Knut Schaekel, Anke Herrmann, Kathrin Meinhardt, Maren Stahl, Christiane Handrick, Sabine Anders, Stephan Weidinger, Jochen Schmitt, Thomas Werfel, the TREATgermany study group   +33 more
wiley   +1 more source

Pathogenic GBA1 Variants and their Interaction with the Gut–Microbiota–Brain Axis in Parkinson's Disease

Movement Disorders, EarlyView.
Helen Dainton‐Howard, Phillip Engen, Kristi Lawrence, Maliha Shaikh, Mohamad Abdel‐Mohsen, Stefan Green, Ankur Naqib, Neha Joshi, Michelle Villanueva, Alana Kirby, Ali Keshavarzian, Christopher Goetz   +11 more
wiley   +1 more source