Results 131 to 140 of about 3,458 (213)

Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity

Advanced Science, Volume 11, Issue 39, October 23, 2024.
Potent small‐molecule inhibitors of Arf1, designated as DU101 and DU102, have been discovered to initiate a series of aging processes in CSCs and systemically remodeled immune microenvironment including increasing the population of tumor‐associated CD8+ CD4+ double‐positive T (DPT) cells in preclinical mouse cancer and PDX models.
Yuetong Wang, Qiaoming Li, Yahui Ding, Chenfei Luo, Jun Yang, Na Wang, Ning Jiang, Tiange Yao, Guohao Wang, Guoming Shi, Steven X. Hou   +10 more
wiley   +1 more source

Correction: Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1. Plants 2015, 4, 691–709

Plants, 2016
The authors wish to make the following corrections to their paper [1].[...]
Anja Smykowski, Stefan M. Fischer, Ulrike Zentgraf   +2 more
doaj   +1 more source

The unfolded protein response links ER stress to cancer-associated thrombosis

JCI Insight, 2023
Thrombosis is a common complication of advanced cancer, yet the cellular mechanisms linking malignancy to thrombosis are poorly understood. The unfolded protein response (UPR) is an ER stress response associated with advanced cancers.
Oluwatoyosi Muse, Rushad Patell, Christian G. Peters, Moua Yang, Emale El-Darzi, Sol Schulman, Anna Falanga, Marina Marchetti, Laura Russo, Jeffrey I. Zwicker, Robert Flaumenhaft   +10 more
doaj   +1 more source

New insights on the role of paired membrane structures in coronavirus replication [PDF]

, 2015
The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles
Al-Mulla, Angelini, Angelini, Barajas, Belov, Benjamin W. Neuman, Bernasconi, Bestebroer, Calì, Chatterjee, Cottam, Cottam, Deng, Edwardson, Egger, Fontana, Gadlage, Gillespie, Gosert, Guix, Hagemeijer, Hagemeijer, Hagemeijer, Hawaa Al-Mulla, Hsu, Hurst, Imbert, Johnson, Kanjanahaluethai, Knoops, Knoops, Knoops, Kopek, Kopek, Krogh, Lauber, Lesemann, Lundin, Magliano, Maier, Maier, Maier, Manolaridis, Medina, Mendez, Miller, Monastyrska, Moreira, Neuman, Neuman, Neuman, Noack, Oostra, Oostra, Pan, Pedersen, Philip V’kovski, Pol, Posthuma, Prentice, Ratia, Reggiori, Richards, Richards, Roberts, Romero-Brey, Romero-Brey, Roosendaal, Rudzinska-Langwald, Saikatendu, Salonen, Sawicki, Schwartz, Schwartz, Serrano, Serrano, Sharma, Snijder, Snijder, Spann, Sparks, Stokes, Suhy, Tan, Teterina, Thuy, Ulasli, van Kasteren, Verheije, Volker Thiel, von Brunn, Welsch, Wojdyla, Wojdyla, Wood, Xu, Xu, Zhao, Zhong, Zirkel   +99 more
core   +1 more source

The SASP factor IL‐6 sustains cell‐autonomous senescent cells via a cGAS‐STING‐NFκB intracrine senescent noncanonical pathway

Aging Cell, Volume 23, Issue 10, October 2024.
Senescent cells produce a secretory phenotype (SASP) that acts on surrounding cells activating multiple responses. In senescent cells the SASP key factor IL‐6 also sustains and amplifies senescence interacting with the intracellular IL‐6R in anterograde traffic structures with cytosolic DNA and cGAS‐STING‐NFκB activation.
Florencia Herbstein, Melanie Sapochnik, Alejandra Attorresi, Cora Pollak, Sergio Senin, David Gonilski‐Pacin, Nicolas Ciancio del Giudice, Manuel Fiz, Belén Elguero, Mariana Fuertes, Lara Müller, Marily Theodoropoulou, Lucas B. Pontel, Eduardo Arzt   +13 more
wiley   +1 more source

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. [PDF]

, 2017
Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis.
Alison Sleigh, Anna Stears, Claire Adams, Felicity Payne, Inês Barroso, Isabel Huang-Doran, Katherine Fawcett, Nuno Rocha, Robert K. Semple, Stephen O’Rahilly, Vladimir Saudek   +10 more
core   +3 more sources

Made to measure: An introduction to quantifying microscopy data in the life sciences

Journal of Microscopy, Volume 295, Issue 1, Page 61-82, July 2024.
Abstract Images are at the core of most modern biological experiments and are used as a major source of quantitative information. Numerous algorithms are available to process images and make them more amenable to be measured. Yet the nature of the quantitative output that is useful for a given biological experiment is uniquely dependent upon the ...
Siân Culley, Alicia Cuber Caballero, Jemima J Burden, Virginie Uhlmann   +3 more
wiley   +1 more source

Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development [PDF]

, 2013
BBX24 and BBX25 are two important transcriptional regulators, which regulate seedling photomorphogenesis in Arabidopsis. Very recently, we have shown that BBX24 and BBX25 negatively regulate the expression of BBX22, reducing the function of HY5, by ...
Botto, Javier Francisco, Gangappa, Sreeramaiah N., Holm, Magnus   +2 more
core   +2 more sources

MYC2 regulates ARR16, a component of cytokinin signaling pathways, in Arabidopsis seedling development

Plant Direct, 2019
MYC2 is a basic helix‐loop‐helix transcription factor that acts as a repressor of blue light‐mediated photomorphogenic growth; however, it promotes lateral root formation.
Archana Kumari Srivastava, Siddhartha Dutta, Sudip Chattopadhyay   +2 more
doaj   +1 more source

Genome-wide association analysis of milk yield traits in Nordic Red Cattle using imputed whole genome sequence variants [PDF]

, 2016
201
Guldbrandtsen, B., Iso-Touru, T., Lund, M. S., Sahana, G., Vilkki, J.   +4 more
core   +18 more sources