Results 151 to 160 of about 1,805 (175)

Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy. [PDF]

Cell Death Dis
Schinke C, Maierhof SK, Hew L, Fernandez Vallone V, Frahm S, Telugu NS, Diecke S, Ivanov A, Kovács R, Beule D, Kirchner M, Mertins P, Brüning U, Kirwan JA, Stachelscheid H, Endres M, Huehnchen P, Boehmerle W.   +17 more
europepmc   +1 more source

Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity [PDF]

American Journal of Physiology - Cell Physiology, 2018
Cellular life requires the activation of the ADP-ribosylation factors (ARFs) by Golgi brefeldin A-resistant factor 1 (GBF1), a guanine nucleotide exchange factor (GEF) with a highly conserved catalytic Sec7 domain (Sec7d). In addition to the Sec7d, GBF1 contains other conserved domains whose functions remain unclear.
Ekaterina G Viktorova, Justyna M Meissner, Eunjoo H Lee   +2 more
exaly   +6 more sources

The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication [PDF]

Journal of Virology, 2019
Rotavirus, a member of the family Reoviridae , is the major cause of severe diarrhea in children and young animals worldwide. Despite significant advances in the characterization of the biology of this virus, the mechanisms involved in morphogenesis of the virus particle are still poorly ...
JOSÉ L Martinez, Francesca Arnoldi, Elisabeth M Schraner   +2 more
exaly   +7 more sources

A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport [PDF]

Developmental Cell, 2019
How can anterograde membrane trafficking be modulated by physiological cues? A screen of Golgi-associated proteins revealed that the ARF-GEF GBF1 can selectively modulate the ER-Golgi trafficking of prohaemostatic von Willebrand factor (VWF) and extracellular matrix (ECM) proteins in human endothelial cells and in mouse fibroblasts.
Jemima J Burden, Francesco Ferraro, Daniel F Cutler   +2 more
exaly   +5 more sources

LG186: An Inhibitor of GBF1 Function that Causes Golgi Disassembly in Human and Canine Cells [PDF]

Traffic, 2010
Brefeldin A-mediated inhibition of ADP ribosylation factor (Arf) GTPases and their guanine nucleotide exchange factors, Arf-GEFs, has been a cornerstone of membrane trafficking research for many years. Brefeldin A (BFA) is relatively non-selective inhibiting at least three targets in human cells, Golgi brefeldin A resistance factor 1 (GBF1), brefeldin ...
Frédéric Boal, Mahel Zeghouf, Robert A Spooner   +2 more
exaly   +5 more sources

Interaction of MYC2 and GBF1 results in functional antagonism in blue light‐mediated Arabidopsis seedling development

Plant Journal, 2015
Regulations of Arabidopsis seedling growth by two proteins, which belong to different classes of transcription factors, are poorly understood. MYC2 and GBF1 belong to bHLH and bZIP classes of transcription factors, respectively, and function in ...
Jay P Maurya, Vishmita Sethi, Sreeramaiah N Gangappa   +2 more
exaly   +2 more sources

Functional and Physical Interaction between the Arf Activator GBF1 and Hepatitis C Virus NS3 Protein

Journal of Virology, 2019
International audienceGBF1 has emerged as a host factor required for the genome replication of RNA viruses of different families. During the hepatitis C virus (HCV) life cycle, GBF1 performs a critical function at the onset of genome replication but is ...
Jean Dubuisson, Catherine L Jackson, Yves Rouillé   +2 more
exaly   +2 more sources

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Rab1b-GBF1-ARF1 Secretory Pathway Axis Is Required for Birnavirus Replication

Journal of Virology, 2022
Birnaviruses are unconventional members of the dsRNA viruses, with the lack of a transcriptionally active core being the main differential feature. This structural trait, among others that resemble those of the plus single-stranded (+ssRNA) viruses features, suggests that birnaviruses might follow a different replication program from that conducted by ...
María C. Gimenez, Yesica R. Frontini-Lopez, Cristian A. Pocognoni, Julieta S. Roldán, Clara García Samartino, Marina Uhart, María I. Colombo, Mauricio R. Terebiznik, Laura R. Delgui   +8 more
openaire   +3 more sources

Molecular interaction of bZIP domains of GBF1, HY5 and HYH inArabidopsisseedling development

Plant Signaling and Behavior, 2013
The bZIP proteins, GBF1, HY5 and HYH, play important regulatory roles in Arabidopsis seedling development. Whereas GBF1 plays a dual regulatory role, HY5 and HYH act as positive regulators of photomorphogenesis.
Hasthi Ram, Sudip Chattopadhyay
exaly   +2 more sources

Dissection of Membrane Dynamics of the ARF-Guanine Nucleotide Exchange Factor GBF1

Traffic, 2005
ADP‐ribosylation factor (ARF)‐facilitated recruitment of COP I to membranes is required for secretory traffic. The guanine nucleotide exchange factor GBF1 activates ARF and regulates ARF/COP I dynamics at the endoplasmic reticulum (ER)–Golgi interface. Like ARF and coatomer, GBF1 peripherally associates with membranes.
Tomasz Szul, Rafael García-Mata, Cecilia Alvarez   +2 more
exaly   +3 more sources