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GBF1 deficiency causes cataracts in human and mouse
Human GeneticsAny opacification of the lens can be defined as cataracts, and lens epithelium cells play a crucial role in guaranteeing lens transparency by maintaining its homeostasis. Although several causative genes of congenital cataracts have been reported, the mechanisms underlying lens opacity remain unclear.
Weimin, Jia +11 more
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The Arf GEF GBF1 Is Required for GGA Recruitment to Golgi Membranes
Traffic, 2007The lysosomal trafficking of the mannose 6‐phosphate receptor and sortilin require that the Golgi‐localized, γ‐ear‐containing, ADP ribosylation factor (Arf)‐binding proteins (GGAs) be recruited to Golgi membranes where they bind a signal in the cytosolic tail of the receptors and recruit clathrin to form trafficking vesicles.
Lefrançois, Stephane +1 more
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Development of Monoclonal Antibodies Against GBF1 and Their Use in Studying Its Functions
Journal of Interferon & Cytokine Research, 2005Interferon-gamma (IFN-gamma) regulates a number of cellular genes using a variety of cellular signaling pathways. Previously, we identified a novel IFN-regulated element, IFN-gamma-activated transcriptional element (GATE), in the promoter of the murine IFN regulatory factor-9 (IRF-9) gene. This element binds to novel factors.
Sanjit K, Roy +5 more
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GBF1 and Arf1 function in vesicular trafficking, lipid homoeostasis and organelle dynamics
Biology of the Cell, 2017AbstractThe ADP‐ribosylation factor (Arf) small G proteins act as molecular switches to coordinate multiple downstream pathways that regulate membrane dynamics. Their activation is spatially and temporally controlled by the guanine nucleotide exchange factors (GEFs).
Beata Kaczmarek +2 more
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GBF1 recruitment to membranes: domains and interacting proteins
2020The Golgi complex resides at the center of the cellular trafficking pathway, where it functions in the modification, sorting, and trafficking of over one third of human proteins to their correct cellular destination. Initiation of vesicle formation at the Golgi requires activation of small GTPases of the ADP-ribosylation factor (Arf) family.
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Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase
Biochemical and Biophysical Research Communications, 2019Rab18 is a small GTPase associated with lipid droplets and other membranes. While it likely has multiple functions on lipid droplets, one proposed function is regulation of lipolysis. Previous work has concentrated on regulation of autophagy; however, in this study, we provide evidence that Rab18 plays a role upstream of the cytosolic lipolytic enzyme ...
Selma Yilmaz, Dejgaard, John F, Presley
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A Molecular Mechanism for GBF1 Recruitment to cis-Golgi Membranes
2017ADP-ribosylation factors (Arfs) play a central role in the regulation of vesicular trafficking through the Golgi. Arfs are activated on cis-Golgi membranes exclusively by the guanine nucleotide exchange factor (GEF) Golgi-specific BFA resistance factor 1 (GBF1), upon recruitment from cytosol. Membrane association of Arf is essential for its activation;
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