Results 1 to 10 of about 12,764 (213)

Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance

Journal of Advanced Research, 2023
Introduction: Acquired resistance to BRAF inhibitor vemurafenib is frequently observed in metastatic colorectal cancer (CRC), and it is a thorny issue that results in treatment failure.
Bin Li
exaly   +3 more sources

Structural basis for the dynamic conformations of AP-4 and its association with ARF1 [PDF]

Nature Communications
Among the distinct adaptor protein (AP) complexes, AP-4 primarily functions as a non-clathrin-coated vesicle machinery essential for intracellular membrane trafficking. ARF1 is a master regulator of AP-4 membrane recruitment, but the underlying mechanism
Yanghui Wang, Wei Li, Yunlong Qiu, Si Wu, Liu Hong, Yan Zhao, Wei Feng   +6 more
doaj   +2 more sources

AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria [PDF]

Cell Death and Disease
Lipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen, Yue Liu, Junzhi Zhang, Tongxing Song, Jian Wu, Zhuqing Ren   +5 more
doaj   +2 more sources

Arf GTPases Define BST-2-Independent Pathways for HIV-1 Assembly and Release [PDF]

Viruses
ADP-ribosylation factor (Arf) proteins are small GTPases that regulate intracellular membrane trafficking and actin remodeling through tightly controlled cycles of GTP binding and hydrolysis.
Adam Smith, Dominique Dotson, Jessica Sutton, Hua Xie, Xinhong Dong   +4 more
doaj   +2 more sources

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target [PDF]

Nature Communications
SARS-CoV-2 and its emerging variants pose continuing threats to public health. SARS-CoV-2 assembles at the ER–Golgi intermediate compartment (ERGIC), where the viral membrane (M) protein highly accumulates to act as the central driver.
Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun, Yun-Jia Ning   +11 more
doaj   +2 more sources

Arf1 GTPase Regulates Golgi‐Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis

Advanced Science
ADP‐ribosylation factor 1 (Arf1) is a small GTPase belonging to the Arf family. As a molecular switch, Arf1 is found to regulate retrograde and intra‐Golgi transport, plasma membrane signaling, and organelle function during mitosis.
Zhen-Nan Pan, Jia-Qian Ju, Shao-Chen Sun
exaly   +2 more sources

Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling [PDF]

EMBO Reports
Tight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I ...
Johannes Lang, Tim Bergner, Julia Zinngrebe, Alice Lepelley, Katharina Vill, Steffen Leiz, Meinhard Wlaschek, Matias Wagner, Karin Scharffetter-Kochanek, Pamela Fischer-Posovszky, Clarissa Read, Yanick J Crow, Maximilian Hirschenberger, Konstantin M J Sparrer   +13 more
doaj   +2 more sources

TAMs-specific ARF1 inhibition reprograms glioma microenvironment and enhances the therapeutic effect of oncolytic adenovirus [PDF]

iScience
Summary: Gliomas, characterized by their robust immunosuppressive microenvironment, pose a significant challenge to the efficacy of immunotherapies. The cGas/STING signaling pathway is emerging as a promising target for cancer immunotherapy.
Tao Cao, Tong Hao, Xiaoru Zhang, Bo Chen, Hongxuan Zhang, Luocheng Shao, Wenqiao He, Bingnan Li, Qihao Zheng, Peng Ji, Ke Tao   +10 more
doaj   +2 more sources

A Commander-independent function of COMMD3 in endosomal trafficking [PDF]

eLife
Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradation in lysosomes.
Galen T Squiers, Chun Wan, James Gorder, Harrison Puscher, Jingshi Shen   +4 more
doaj   +2 more sources

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia [PDF]

Advanced Science
Lipid metabolism disorders in both neurons and glial cells have been found in neurodegenerative (ND) patients and animal models. However, the pathological connection between lipid droplets and NDs remains poorly understood.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
doaj   +2 more sources