Results 1 to 10 of about 7,868 (194)

Arf1 GTPase Regulates Golgi‐Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis

Advanced Science
ADP‐ribosylation factor 1 (Arf1) is a small GTPase belonging to the Arf family. As a molecular switch, Arf1 is found to regulate retrograde and intra‐Golgi transport, plasma membrane signaling, and organelle function during mitosis.
Meng-Meng Shan, Zhen-Nan Pan, Jia-Qian Ju   +2 more
exaly   +3 more sources

Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance

Journal of Advanced Research, 2023
Introduction: Acquired resistance to BRAF inhibitor vemurafenib is frequently observed in metastatic colorectal cancer (CRC), and it is a thorny issue that results in treatment failure.
Hui-Fang Hu, Yunlong Pan, Qing-Yu He
exaly   +3 more sources

Structural basis for the dynamic conformations of AP-4 and its association with ARF1 [PDF]

Nature Communications
Among the distinct adaptor protein (AP) complexes, AP-4 primarily functions as a non-clathrin-coated vesicle machinery essential for intracellular membrane trafficking. ARF1 is a master regulator of AP-4 membrane recruitment, but the underlying mechanism
Yanghui Wang, Wei Li, Yunlong Qiu, Si Wu, Liu Hong, Yan Zhao, Wei Feng   +6 more
doaj   +2 more sources

Design and Synthesis of Arf1-Targeting γ-Dipeptides as Potential Agents against Head and Neck Squamous Cell Carcinoma

Cells, 2020
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related deaths and calls for new druggable targets. We have previously highlighted the critical role of ADP-ribosylation factor-1 (Arf1) activation in HNSCC.
Yen Vo-Hoang, Leilei He, Yong Teng
exaly   +3 more sources

Arf GTPases Define BST-2-Independent Pathways for HIV-1 Assembly and Release [PDF]

Viruses
ADP-ribosylation factor (Arf) proteins are small GTPases that regulate intracellular membrane trafficking and actin remodeling through tightly controlled cycles of GTP binding and hydrolysis.
Adam Smith, Dominique Dotson, Jessica Sutton, Hua Xie, Xinhong Dong   +4 more
doaj   +2 more sources

AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria [PDF]

Cell Death and Disease
Lipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen, Yue Liu, Junzhi Zhang, Tongxing Song, Jian Wu, Zhuqing Ren   +5 more
doaj   +2 more sources

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection. [PDF]

New Phytol
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Cana-Quijada P, Morales-Martínez P, Rosas-Díaz T, Pérez-Sancho J, Jiménez-Góngora T, Navarro JA, Lozano-Durán R, Castillo AG, Pallás V, Bejarano ER.   +9 more
europepmc   +2 more sources

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target [PDF]

Nature Communications
SARS-CoV-2 and its emerging variants pose continuing threats to public health. SARS-CoV-2 assembles at the ER–Golgi intermediate compartment (ERGIC), where the viral membrane (M) protein highly accumulates to act as the central driver.
Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun, Yun-Jia Ning   +11 more
doaj   +2 more sources

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Miller SJ, Prokopenko D, Bai P, Mondal P, Scott A, Zhang W, Gomm A, Zhang S, Child DD, Shen N, Ward J, Schulte S, Lei D, Hafler BP, Wang C, Tanzi RE, Zhang C.   +16 more
europepmc   +2 more sources

TAMs-specific ARF1 inhibition reprograms glioma microenvironment and enhances the therapeutic effect of oncolytic adenovirus [PDF]

iScience
Summary: Gliomas, characterized by their robust immunosuppressive microenvironment, pose a significant challenge to the efficacy of immunotherapies. The cGas/STING signaling pathway is emerging as a promising target for cancer immunotherapy.
Tao Cao, Tong Hao, Xiaoru Zhang, Bo Chen, Hongxuan Zhang, Luocheng Shao, Wenqiao He, Bingnan Li, Qihao Zheng, Peng Ji, Ke Tao   +10 more
doaj   +2 more sources