Results 11 to 20 of about 7,868 (194)
ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis [PDF]
Cell Communication and Signaling, 2017 Background The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils.
Yuichi Mazaki +5 more
doaj +6 more sources
Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. [PDF]
PLoS ONE, 2013 Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family in their active GTP-bound state. It has been proposed that BAR domains are able to sense membrane curvature and to induce membrane tubulation.
Ernesto E Ambroggio +4 more
doaj +6 more sources
Arf1 facilitates mast cell proliferation via the mTORC1 pathway
Scientific Reports, 2022 Mast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking ...
Yui Kotani +4 more
doaj +2 more sources
ARF1 Regulates Nef-Induced CD4 Degradation [PDF]
Current Biology, 2004 The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.Here we report that the small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4.
Faure, Julien +7 more
openaire +4 more sources
Structure and Membrane Interaction of Myristoylated ARF1 [PDF]
Structure, 2009 ADP-ribosylation factors (ARFs) are small (21 kDa), monomeric GTPases that are important regulators of membrane traffic. When membrane bound, they recruit soluble adaptors to membranes and trigger the assembly of coating complexes involved in cargo selection and vesicular budding.
Liu, Yizhou +2 more
openaire +3 more sources
Hazara Nairovirus Requires COPI Components in both Arf1-Dependent and Arf1-Independent Stages of Its Replication Cycle [PDF]
Journal of Virology, 2020 Nairoviruses are tick-borne enveloped RNA viruses that include several pathogens responsible for fatal disease in humans and animals. Here, we analyzed host genes involved in trafficking networks to examine their involvement in nairovirus replication.
Álvarez-Rodríguez, B +5 more
openaire +4 more sources
ARF1 Frequency and Amplitude Curve Calibration [PDF]
, 2001 ARF1 was calibrated and checked on 4/18/01. The technique used was to set the start/stop timers (A:R1LLT1 and A:R1LLT2) for duration of 200 msec. Driving the cavities for longer than 200 msec at full voltage could put some stress on the Hipotronics anode supply. The Camac curve generator card was substituted with a precision DC voltage source. Data for
Pasquinelli, Ralph J., Ralph Pasquinelli
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Mutational Analysis of the Arf1•GTP/Arf GAP Interface Reveals an Arf1 Mutant that Selectively Affects the Arf GAP ASAP1 [PDF]
Current Biology, 2005 Arf1 is a GTP binding protein that functions at a number of cellular sites to control membrane traffic and actin remodeling. Arf1 is regulated by site-specific GTPase-activating proteins (GAPs). The combined results of crystallographic and biochemical studies have led to the proposal that Arf1 GAPs differ in the specific interface formed with Arf1.
Luo, Ruibai +5 more
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ARF1 is directly involved in dynamin-independent endocytosis [PDF]
Nature Cell Biology, 2007 Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid phase takes place primarily through a dynamin- and clathrin-independent, Cdc42-regulated pinocytic mechanism. This mechanism is mediated by primary carriers called clathrin-independent carriers (CLICs), which fuse to form tubular early endocytic compartments ...
Sudha, Kumari, Satyajit, Mayor
openaire +3 more sources
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling [PDF]
EMBO ReportsTight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I ...
Johannes Lang +13 more
doaj +2 more sources