Results 11 to 20 of about 12,764 (213)

Arf1 facilitates mast cell proliferation via the mTORC1 pathway

Scientific Reports, 2022
Mast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking ...
Yui Kotani, Mami Sumiyoshi, Megumi Sasada, Toshio Watanabe, Satoshi Matsuda   +4 more
doaj   +3 more sources

ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis [PDF]

Cell Communication and Signaling, 2017
Background The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils.
Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa, Hisataka Sabe   +5 more
doaj   +4 more sources

Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. [PDF]

PLoS ONE, 2013
Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family in their active GTP-bound state. It has been proposed that BAR domains are able to sense membrane curvature and to induce membrane tubulation.
Ernesto E Ambroggio, James Sillibourne, Bruno Antonny, Jean-Baptiste Manneville, Bruno Goud   +4 more
doaj   +4 more sources

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection. [PDF]

New Phytol
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Cana-Quijada P, Morales-Martínez P, Rosas-Díaz T, Pérez-Sancho J, Jiménez-Góngora T, Navarro JA, Lozano-Durán R, Castillo AG, Pallás V, Bejarano ER.   +9 more
europepmc   +2 more sources

ARF1-related disorder: phenotypic and molecular spectrum [PDF]

Journal of Medical Genetics, 2023
Purpose ARF1 was previously implicated in periventricular nodular heterotopia (PVNH) in only five individuals and systematic clinical characterisation was not available. The aim of this study is to provide a comprehensive description of the phenotypic and genotypic spectrum of ARF1-related ...
de Sainte Agathe, Jean-Madeleine, Pode-Shakked, Ben, Naudion, Sophie, Michaud, Vincent, Arveiler, Benoit, Fergelot, Patricia, Delmas, Jean, Keren, Boris, Poirsier, Céline, Alkuraya, Fowzan, Tabarki, Brahim, Bend, Eric, Davis, Kellie, Bebin, Martina, Thompson, Michelle, Bryant, Emily, Wagner, Matias, Hannibal, Iris, Lenberg, Jerica, Krenn, Martin, Wigby, Kristen, Friedman, Jennifer, Iascone, Maria, Cereda, Anna, Miao, Térence, Leguern, Eric, Argilli, Emanuela, Sherr, Elliott, Caluseriu, Oana, Tidwell, Timothy, Bayrak-Toydemir, Pinar, Hagedorn, Caroline, Brugger, Melanie, Vill, Katharina, Morneau-Jacob, Francois-Dominique, Chung, Wendy, Weaver, Kathryn, Owens, Joshua, Husami, Ammar, Chaudhari, Bimal, Stone, Brandon, Burns, Katie, Li, Rachel, de Lange, Iris, Biehler, Margaux, Ginglinger, Emmanuelle, Gérard, Bénédicte, Stottmann, Rolf, Trimouille, Aurélien   +48 more
openaire   +7 more sources

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Miller SJ, Prokopenko D, Bai P, Mondal P, Scott A, Zhang W, Gomm A, Zhang S, Child DD, Shen N, Ward J, Schulte S, Lei D, Hafler BP, Wang C, Tanzi RE, Zhang C.   +16 more
europepmc   +2 more sources

ARF1 Regulates Nef-Induced CD4 Degradation [PDF]

Current Biology, 2004
The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.Here we report that the small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4.
Faure, Julien, Stalder Monney, Romaine, Borel, Christelle, Sobo, Komla, Piguet, Vincent, Demaurex, Nicolas, Gruenberg, Jean, Trono, Didier   +7 more
openaire   +3 more sources

The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells

Frontiers in Pharmacology, 2022
The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates prostate cancer progression, but its function and regulation in oncogenic mitogen-activate protein kinase (MAPK) activation are poorly defined.
Xin Xu, Mostafa Khater, Guangyu Wu
doaj   +1 more source

Hazara Nairovirus Requires COPI Components in both Arf1-Dependent and Arf1-Independent Stages of Its Replication Cycle [PDF]

Journal of Virology, 2020
Nairoviruses are tick-borne enveloped RNA viruses that include several pathogens responsible for fatal disease in humans and animals. Here, we analyzed host genes involved in trafficking networks to examine their involvement in nairovirus replication.
Álvarez-Rodríguez, B, Fuller, J, Todd, EJAA, Mankouri, J, Hewson, R, Barr, JN   +5 more
openaire   +2 more sources