Results 41 to 50 of about 7,868 (194)
Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction
European Journal of Medicinal Chemistry Reports, 2022 The GDP/GTP conformational change of Arf GTPase proteins by different guanine exchange factor GEFs proteins (Big1Sec7, ARNOSec7, Brag1Sec7, etc.), modulates important eukaryotes cell functions, such as secretion, endocytosis, phagocytosis, cytokinesis ...
Sergio Ortiz +7 more
doaj +1 more source
Identification of novel Arf1 GTPase inhibitors for cancer target validation
, 2023 The key regulators of both anterograde and retrograde vesicular traffic, adenosine diphosphate-ribosylation factors (Arfs), also coordinate various signalling pathways and regulate cellular processes required for cell survival and function.
Mqwathi, Nomxolisi Vuyokasi
core +1 more source
ARF1 Localizes to the Golgi and the Trans-Golgi Network [PDF]
The Plant Cell, 2011 The recruitment of coat proteins for transport vesicles (COPI-, COPII-, and clathrin-coated) is mediated by the small GTPases of the ADP-ribosylation factor (ARF) family of which there are three SAR , 12 ARF , and six ARL genes in the Arabidopsis thaliana genome ([Vernoud et al., 2003][1 ...
Robinson, David G +3 more
openaire +3 more sources
eLife, 2014 Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors.
Florian Wilfling +10 more
doaj +1 more source
A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1. [PDF]
, 2023 ADP-ribosylation factor 1 (ARF1) is a small GTPase that regulates membrane traffic at the Golgi apparatus and endosomes through recruitment of several coat proteins and lipid-modifying enzymes.
Freeman, Christina +6 more
core +1 more source
The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]
, 2013 Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang +13 more
core +1 more source
The spatiotemporal basis for the function and regulation of Arf1 at the Golgi
, 2023 173 pagesThe Golgi complex serves as the cellular hub for intracellular membrane trafficking. Golgi trafficking is orchestrated by the small GTPase Arf1, which recruits several effector proteins to the Golgi membrane at precise points in cisternal ...
Manzer, Kaitlyn
core +1 more source
, 2013 (A) The effects of expression of the ARF-CFP chimeras on the binding of opsonized target particles. The ARF1-CFP chimeras generally reduced the binding index of macrophages, while the ARF6-CFP chimeras did not affect target particle binding. (
Adam D Hoppe (57946) +2 more
core +1 more source
ARF1 at the crossroads of podosome construction and function [PDF]
Journal of Cell Biology, 2016 Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation ...
openaire +2 more sources
Interaktionen der kleinen GTPase Arf1 mit Coatomer
, 2015 Zusammenfassung COPI-Vesikel sind für den retrograden Transport von Proteinen und Lipiden vom Golgi-Apparat zurück zum ER und für den bidirektionalen Transport innerhalb des Golgi-Apparates verantwortlich.
Röhling, Simone
core +1 more source