Results 41 to 50 of about 12,764 (213)
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
PLoS Biology, 2006 Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily.
Peter Beemiller +2 more
doaj +1 more source
Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity [PDF]
, 1926 Cell-penetrating peptides (CPPs) are a promising group of delivery vectors for various therapeutic agents but their application is often hampered by poor stability in the presence of serum.
Holm, Tina +6 more
core +1 more source
Golgicide A Reveals Essential Roles for GBF1 in Golgi Assembly and Function [PDF]
, 2013 ADP-ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs) which confer spatial and temporal ...
Bursulaya, Badry +6 more
core +1 more source
mBio, 2021 Chlamydia trachomatis is an obligate intracellular bacterium that has developed sophisticated mechanisms to survive inside its infectious compartment, the inclusion. Notably, Chlamydia weaves an extensive network of microtubules (MTs) and actin filaments
Adam Haines +4 more
doaj +1 more source
Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO [PDF]
, 2016 published_or_final_versio
Bershadsky, AD +6 more
core +3 more sources
Frontiers in Cell and Developmental Biology, 2018 When eukaryotic cells divide, they must faithfully segregate not only the genetic material but also their membrane-bound organelles into each daughter cell.
Catherine L. Jackson
doaj +1 more source
Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. [PDF]
PLoS ONE, 2014 Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis.
Jeffrey D Covington +7 more
doaj +1 more source
Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi
Cell Reports, 2016 The GTPase Arf1 is the major regulator of vesicle traffic at both the cis- and trans-Golgi. Arf1 is activated at the cis-Golgi by the guanine nucleotide exchange factor (GEF) GBF1 and at the trans-Golgi by the related GEF BIG1 or its paralog, BIG2.
Antonio Galindo +5 more
doaj +1 more source
Traffic jam on the cellular secretory pathway generated by a replication protein from a plant RNA virus [PDF]
, 2014 Although positive-strand RNA [(+)RNA] viruses have a limited coding capacity, they can replicate efficiently in host cells because of their ability to use host-derived proteins, membranes, lipids, and metabolites, and to rewire cellular trafficking ...
Hyodo, Kiwamu +2 more
core +1 more source