Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis [PDF]
Nature Cell Biology, 2023 AbstractLipid mobilization through fatty acid β-oxidation is a central process essential for energy production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome from where β-oxidation products enter mitochondria and fuel the tricarboxylic acid cycle.
Ludovic Enkler +11 more
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ARF1(2–17) does not specifically interact with ARF1‐dependent pathways
FEBS Letters, 1994 The small GTP‐binding protein ARF has been shown recently to regulate phospholipase D (PLD). In order to investigate the role of ARF proteins in regulated exocytosis, we have used the N‐terminal peptide ARF1(2–17) of the ARF1 protein. ARF1 reconstituted PLD activity in cytosol‐depleted HL60 cells was inhibited by ARF1(2–17).
Fensome, Amanda +3 more
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PLoS Biology, 2006 Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily.
Peter Beemiller +2 more
doaj +2 more sources
In vivo monitoring of the recruitment and activation of AP-1 by Arf1 [PDF]
Scientific Reports, 2017 AP-1 is a clathrin adaptor recruited to the trans-Golgi Network where it can interact with specific signals found in the cytosolic tail of cargo proteins to incorporate them into clathrin-coated vesicles for trafficking.
Etienne Sauvageau +2 more
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The small
The EMBO Journal, 2014 Abstract The small GTP ase Arf1 plays critical roles in membrane traffic by initiating the recruitment of coat proteins and by modulating the activity of lipid‐modifying enzymes. Here, we report an unexpected but evolutionarily conserved role for Arf1 and the Arf
Ackema, K. B. +9 more
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A structural study of the myristoylated N-terminus of ARF1
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 The effect of myristoylation on the 15-amino-acid peptide from the membrane-binding N-terminus of ADP ribosylation factor 1 (ARF1) was studied using neutron diffraction and circular dichroism. A previous study on the non-acylated form indicated that the peptide lies parallel to the membrane, at a shallow depth and in the vicinity of the ...
Harroun, Thad +3 more
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A Commander-independent function of COMMD3 in endosomal trafficking [PDF]
eLifeEndosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradation in lysosomes.
Galen T Squiers +4 more
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ARF1 -related disorder: Phenotypic and molecular spectrum [PDF]
, 2023 Purpose ARF1 was previously implicated in periventricular nodular heterotopia (PVNH) in only five individuals and systematic clinical characterisation was not available. The aim of this study is to provide a comprehensive description of the phenotypic and genotypic spectrum of ARF1-related neurodevelopmental disorder.
De Sainte Agathe,Jean Madeleine +50 more
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AXL receptor tyrosine kinase regulates Golgi organization and function via an adhesion-Arf1 signalling axis in breast and lung cancer cell lines [PDF]
Biology OpenPrachi Joshi +7 more
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Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity
Advanced ScienceThe small G protein Arf1 has been identified as playing a selective role in supporting cancer stem cells (CSCs), making it an attractive target for cancer therapy.
Yuetong Wang, Steven X Hou
exaly +2 more sources