Results 21 to 30 of about 6,923 (171)

Mutational Analysis of Saccharomyces cerevisiae ARF1 [PDF]

Journal of Biological Chemistry, 1995
Wild type and eight point mutants of Saccharomyces cerevisiae ARF1 were expressed in yeast and bacteria to determine the roles of specific residues in in vivo and in vitro activities. Mutations at either Gly2 or Asp26 resulted in recessive loss of function.
R A, Kahn, J, Clark, C, Rulka, T, Stearns, C J, Zhang, P A, Randazzo, T, Terui, M, Cavenagh   +7 more
openaire   +2 more sources

Design and Synthesis of Arf1-Targeting γ-Dipeptides as Potential Agents against Head and Neck Squamous Cell Carcinoma

Cells, 2020
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related deaths and calls for new druggable targets. We have previously highlighted the critical role of ADP-ribosylation factor-1 (Arf1) activation in HNSCC.
Yen Vo-Hoang, Sergio Paiva, Leilei He, Sébastien Estaran, Yong Teng   +4 more
doaj   +1 more source

Reliable reference genes for gene expression analyses under the hypomagnetic field in a migratory insect

Frontiers in Physiology, 2022
Manipulating the hypomagnetic field (HMF), which is the absence or significant weakening (<5 μT) of the geomagnetic field (GMF), offers a unique tool to investigate magnetic field effects on organismal physiology, development, behavior and life ...
Ying Zhang, Ying Zhang, Luying Zeng, Luying Zeng, Yongji Wei, Yongji Wei, Ming Zhang, Ming Zhang, Weidong Pan, Gregory A. Sword, Fei Yang, Fajun Chen, Fajun Chen, Guijun Wan, Guijun Wan   +14 more
doaj   +1 more source

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Nature Communications, 2023
Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling. Termination
Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry-Barca, Fanny Wondany, Tim Bergner, Tatiana Moreau, Mathieu P. Rodero, Reinhild Rösler, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally-Ann Lynch, Marte G. Haug, Gunnar Houge, Kristen M. Wigby, Jessica Sprague, Jerica Lenberg, Clarissa Read, Paul Walther, Jens Michaelis, Frank Kirchhoff, Carina C. de Oliveira Mann, Yanick J. Crow, Konstantin M. J. Sparrer   +29 more
doaj   +1 more source

Degradation of the auxin response factor ARF1 [PDF]

The Plant Journal, 2007
SummaryAuxin‐mediated gene expression is largely controlled through a family of DNA‐binding proteins known as auxin response factors (ARF). Previous studies on the role of proteolytic regulation in auxin signaling have focused on degradation of their interacting partner, the Aux/IAA proteins.
Salmon, J., Ramos, J., Callis, J.
openaire   +2 more sources

Structure and Membrane Interaction of Myristoylated ARF1 [PDF]

Structure, 2009
ADP-ribosylation factors (ARFs) are small (21 kDa), monomeric GTPases that are important regulators of membrane traffic. When membrane bound, they recruit soluble adaptors to membranes and trigger the assembly of coating complexes involved in cargo selection and vesicular budding.
Liu, Yizhou, Kahn, Richard A., Prestegard, James H.   +2 more
openaire   +2 more sources

Hazara Nairovirus Requires COPI Components in both Arf1-Dependent and Arf1-Independent Stages of Its Replication Cycle [PDF]

Journal of Virology, 2020
Nairoviruses are tick-borne enveloped RNA viruses that include several pathogens responsible for fatal disease in humans and animals. Here, we analyzed host genes involved in trafficking networks to examine their involvement in nairovirus replication.
Álvarez-Rodríguez, B, Fuller, J, Todd, EJAA, Mankouri, J, Hewson, R, Barr, JN   +5 more
openaire   +3 more sources

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1

Nature Communications, 2023
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics.
Yue Zhang, Olivier Soubias, Shashank Pant, Frank Heinrich, Alexander Vogel, Jess Li, Yifei Li, Luke A. Clifton, Sebastian Daum, Kirsten Bacia, Daniel Huster, Paul A. Randazzo, Mathias Lösche, Emad Tajkhorshid, R. Andrew Byrd   +14 more
doaj   +1 more source

ARF1 Regulates Nef-Induced CD4 Degradation [PDF]

Current Biology, 2004
The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.Here we report that the small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4.
Faure, Julien, Stalder Monney, Romaine, Borel, Christelle, Sobo, Komla, Piguet, Vincent, Demaurex, Nicolas, Gruenberg, Jean, Trono, Didier   +7 more
openaire   +3 more sources

A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis.

PLoS Genetics, 2018
In eukaryotes, GTP-bound ARF GTPases promote intracellular membrane traffic by mediating the recruitment of coat proteins, which in turn sort cargo proteins into the forming membrane vesicles.
Manoj K Singh, Sandra Richter, Hauke Beckmann, Marika Kientz, York-Dieter Stierhof, Nadine Anders, Florian Fäßler, Michael Nielsen, Christian Knöll, Alexis Thomann, Mirita Franz-Wachtel, Boris Macek, Karen Skriver, Peter Pimpl, Gerd Jürgens   +14 more
doaj   +1 more source