Results 31 to 40 of about 7,868 (194)

Architecture of clathrin-independent AP3:ARF1-coated carriers. [PDF]

Sci Adv
The AP3 complex mediates cargo sorting and carrier assembly for the trafficking of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed to localise to clathrin-free, ARF1 positive, elongated carriers in cells, but the ...
Kaufman JGG, Tagiltsev G, Stalder DS, Taylor RJ, Sava I, Guo H, Ciazynska KA, Zaccai NR, Gray SR, Vallis Y, Höning S, Kelly BT, Gershlick DC, Briggs JAG, Owen DJ.   +14 more
europepmc   +2 more sources

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

ARF1-related disorder: phenotypic and molecular spectrum [PDF]

Journal of Medical Genetics, 2023
Purpose ARF1 was previously implicated in periventricular nodular heterotopia (PVNH) in only five individuals and systematic clinical characterisation was not available. The aim of this study is to provide a comprehensive description of the phenotypic and genotypic spectrum of ARF1-related ...
de Sainte Agathe, Jean-Madeleine, Pode-Shakked, Ben, Naudion, Sophie, Michaud, Vincent, Arveiler, Benoit, Fergelot, Patricia, Delmas, Jean, Keren, Boris, Poirsier, Céline, Alkuraya, Fowzan, Tabarki, Brahim, Bend, Eric, Davis, Kellie, Bebin, Martina, Thompson, Michelle, Bryant, Emily, Wagner, Matias, Hannibal, Iris, Lenberg, Jerica, Krenn, Martin, Wigby, Kristen, Friedman, Jennifer, Iascone, Maria, Cereda, Anna, Miao, Térence, Leguern, Eric, Argilli, Emanuela, Sherr, Elliott, Caluseriu, Oana, Tidwell, Timothy, Bayrak-Toydemir, Pinar, Hagedorn, Caroline, Brugger, Melanie, Vill, Katharina, Morneau-Jacob, Francois-Dominique, Chung, Wendy, Weaver, Kathryn, Owens, Joshua, Husami, Ammar, Chaudhari, Bimal, Stone, Brandon, Burns, Katie, Li, Rachel, de Lange, Iris, Biehler, Margaux, Ginglinger, Emmanuelle, Gérard, Bénédicte, Stottmann, Rolf, Trimouille, Aurélien   +48 more
openaire   +5 more sources

The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells

Frontiers in Pharmacology, 2022
The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates prostate cancer progression, but its function and regulation in oncogenic mitogen-activate protein kinase (MAPK) activation are poorly defined.
Xin Xu, Mostafa Khater, Guangyu Wu
doaj   +1 more source

Mutational Analysis of Saccharomyces cerevisiae ARF1 [PDF]

Journal of Biological Chemistry, 1995
Wild type and eight point mutants of Saccharomyces cerevisiae ARF1 were expressed in yeast and bacteria to determine the roles of specific residues in in vivo and in vitro activities. Mutations at either Gly2 or Asp26 resulted in recessive loss of function.
R A, Kahn, J, Clark, C, Rulka, T, Stearns, C J, Zhang, P A, Randazzo, T, Terui, M, Cavenagh   +7 more
openaire   +2 more sources

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Nature Communications, 2023
Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling. Termination
Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry-Barca, Fanny Wondany, Tim Bergner, Tatiana Moreau, Mathieu P. Rodero, Reinhild Rösler, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally-Ann Lynch, Marte G. Haug, Gunnar Houge, Kristen M. Wigby, Jessica Sprague, Jerica Lenberg, Clarissa Read, Paul Walther, Jens Michaelis, Frank Kirchhoff, Carina C. de Oliveira Mann, Yanick J. Crow, Konstantin M. J. Sparrer   +29 more
doaj   +1 more source

Reliable reference genes for gene expression analyses under the hypomagnetic field in a migratory insect

Frontiers in Physiology, 2022
Manipulating the hypomagnetic field (HMF), which is the absence or significant weakening (<5 μT) of the geomagnetic field (GMF), offers a unique tool to investigate magnetic field effects on organismal physiology, development, behavior and life ...
Ying Zhang, Ying Zhang, Luying Zeng, Luying Zeng, Yongji Wei, Yongji Wei, Ming Zhang, Ming Zhang, Weidong Pan, Gregory A. Sword, Fei Yang, Fajun Chen, Fajun Chen, Guijun Wan, Guijun Wan   +14 more
doaj   +1 more source

Degradation of the auxin response factor ARF1 [PDF]

The Plant Journal, 2007
SummaryAuxin‐mediated gene expression is largely controlled through a family of DNA‐binding proteins known as auxin response factors (ARF). Previous studies on the role of proteolytic regulation in auxin signaling have focused on degradation of their interacting partner, the Aux/IAA proteins.
Salmon, J., Ramos, J., Callis, J.
openaire   +2 more sources

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1

Nature Communications, 2023
ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin dynamics.
Yue Zhang, Olivier Soubias, Shashank Pant, Frank Heinrich, Alexander Vogel, Jess Li, Yifei Li, Luke A. Clifton, Sebastian Daum, Kirsten Bacia, Daniel Huster, Paul A. Randazzo, Mathias Lösche, Emad Tajkhorshid, R. Andrew Byrd   +14 more
doaj   +1 more source

A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis.

PLoS Genetics, 2018
In eukaryotes, GTP-bound ARF GTPases promote intracellular membrane traffic by mediating the recruitment of coat proteins, which in turn sort cargo proteins into the forming membrane vesicles.
Manoj K Singh, Sandra Richter, Hauke Beckmann, Marika Kientz, York-Dieter Stierhof, Nadine Anders, Florian Fäßler, Michael Nielsen, Christian Knöll, Alexis Thomann, Mirita Franz-Wachtel, Boris Macek, Karen Skriver, Peter Pimpl, Gerd Jürgens   +14 more
doaj   +1 more source