Results 31 to 40 of about 6,923 (171)

Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction

European Journal of Medicinal Chemistry Reports, 2022
The GDP/GTP conformational change of Arf GTPase proteins by different guanine exchange factor GEFs proteins (Big1Sec7, ARNOSec7, Brag1Sec7, etc.), modulates important eukaryotes cell functions, such as secretion, endocytosis, phagocytosis, cytokinesis ...
Sergio Ortiz, François Peurois, Euzébio Guimarães Barbosa, Mohamed Selkti, Pascale Lemoine, Jacqueline Cherfils, Raphaël Grougnet, Sabrina Boutefnouchet   +7 more
doaj   +1 more source

ARF1 Localizes to the Golgi and the Trans-Golgi Network [PDF]

The Plant Cell, 2011
The recruitment of coat proteins for transport vesicles (COPI-, COPII-, and clathrin-coated) is mediated by the small GTPases of the ADP-ribosylation factor (ARF) family of which there are three SAR , 12 ARF , and six ARL genes in the Arabidopsis thaliana genome ([Vernoud et al., 2003][1 ...
Robinson, David G, Scheuring, David, Naramoto, Satoshi, Friml, Jiri   +3 more
openaire   +3 more sources

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

eLife, 2014
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors.
Florian Wilfling, Abdou Rachid Thiam, Maria-Jesus Olarte, Jing Wang, Rainer Beck, Travis J Gould, Edward S Allgeyer, Frederic Pincet, Jörg Bewersdorf, Robert V Farese Jr, Tobias C Walther   +10 more
doaj   +1 more source

A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.

PLoS Biology, 2006
Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily.
Peter Beemiller, Adam D Hoppe, Joel A Swanson   +2 more
doaj   +1 more source

ARF1 at the crossroads of podosome construction and function [PDF]

Journal of Cell Biology, 2016
Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation ...
openaire   +2 more sources

Activators and Effectors of the Small G Protein Arf1 in Regulation of Golgi Dynamics During the Cell Division Cycle

Frontiers in Cell and Developmental Biology, 2018
When eukaryotic cells divide, they must faithfully segregate not only the genetic material but also their membrane-bound organelles into each daughter cell.
Catherine L. Jackson
doaj   +1 more source

Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi

Cell Reports, 2016
The GTPase Arf1 is the major regulator of vesicle traffic at both the cis- and trans-Golgi. Arf1 is activated at the cis-Golgi by the guanine nucleotide exchange factor (GEF) GBF1 and at the trans-Golgi by the related GEF BIG1 or its paralog, BIG2.
Antonio Galindo, Nicolas Soler, Stephen H. McLaughlin, Minmin Yu, Roger L. Williams, Sean Munro   +5 more
doaj   +1 more source

Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. [PDF]

PLoS ONE, 2014
Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis.
Jeffrey D Covington, Jose E Galgani, Cedric Moro, Jamie M LaGrange, Zhengyu Zhang, Arild C Rustan, Eric Ravussin, Sudip Bajpeyi   +7 more
doaj   +1 more source

Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection

mBio, 2021
Chlamydia trachomatis is an obligate intracellular bacterium that has developed sophisticated mechanisms to survive inside its infectious compartment, the inclusion. Notably, Chlamydia weaves an extensive network of microtubules (MTs) and actin filaments
Adam Haines, Jordan Wesolowski, Nathan M. Ryan, Tiago Monteiro-Brás, Fabienne Paumet   +4 more
doaj   +1 more source

The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1.

PLoS Pathogens, 2023
The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required for ...
Ekaterina G Viktorova, Samuel Gabaglio, Seyedehmahsa Moghimi, Anna Zimina, Bridge G Wynn, Elizabeth Sztul, George A Belov   +6 more
doaj   +1 more source