Results 51 to 60 of about 12,764 (213)

The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1.

PLoS Pathogens, 2023
The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required for ...
Ekaterina G Viktorova, Samuel Gabaglio, Seyedehmahsa Moghimi, Anna Zimina, Bridge G Wynn, Elizabeth Sztul, George A Belov   +6 more
doaj   +1 more source

Review article

, 2019
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core   +1 more source

5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail [PDF]

, 2011
The 5-HT2AR (5-hydroxytryptamine-2A receptor) is a GPCR (G-protein-coupled receptor) that is implicated in the actions of hallucinogens and represents a major target of atypical antipsychotic agents.
Abbas, Banes, Berg, Bhattacharya, Cockcroft, Dean, Derek N. Robertson, Du, Du, Du, Eve M. Lutz, Fensome, Garrido, Gonzalez-Maeso, Gooz, Guillet-Deniau, Hammond, Hanke, Heuss, Hoyer, Ichikawa, Johnson, Johnson-Farley, Klein, Koch, Kurrasch-Orbaugh, Kurrasch-Orbaugh, Lavieri, Lee, Lehmann, Liting Sun, Louise Dickson, McCulloch, Melanie S. Johnson, Mitchell, Mitchell, Mitchell, Moya, Pamela J. Holland, Pehek, Perez-Mansilla, Quinn, Rajagopal, Rankovic, Rizzo, Roberta Rosie, Robertson, Rory Mitchell, Roth, Schmid, Schmidt, Scott, Shome, Sue Fleetwood-Walker, Sun, Tian, Yu, Zeniou-Meyer, Zoë Barclay   +58 more
core   +3 more sources

Vps74p controls Golgi size in an Arf1‐dependent manner [PDF]

FEBS Letters, 2018
The oncogene GOLPH3 is implicated in Golgi size regulation, a function yet to be experimentally linked to its PI4P effector function or the Golgi cisternal maturation in general. Moreover, its yeast homolog, Vps74p is not yet implicated in Golgi size regulation.
Prasanna Iyer, Madhura Bhave, Bhawik Kumar Jain, Sudeshna RoyChowdhury, Dibyendu Bhattacharyya   +4 more
openaire   +2 more sources

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +5 more sources

In vivo monitoring of the recruitment and activation of AP-1 by Arf1

Scientific Reports, 2017
AP-1 is a clathrin adaptor recruited to the trans-Golgi Network where it can interact with specific signals found in the cytosolic tail of cargo proteins to incorporate them into clathrin-coated vesicles for trafficking.
Etienne Sauvageau, Peter J. McCormick, Stephane Lefrancois   +2 more
doaj   +1 more source

Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. [PDF]

PLoS Biology, 2005
Semliki forest virus (SFV) is internalized by clathrin-mediated endocytosis, and transported via early endosomes to late endosomes and lysosomes. The intracellular pathway taken by individual fluorescently labeled SFV particles was followed using ...
Andreas Vonderheit, Ari Helenius
doaj   +2 more sources

Defects in the Secretory Pathway and High Ca2+ Induce Multiple P-bodies [PDF]

, 2010
Monitoring Editor: Reid Gilmore mRNA is sequestered and turned over in cytoplasmic processing bodies (PBs), which are induced by various cellular stresses. Unexpectedly, in S.
Cornelia Kilchert, Julie Weidner, Cristina Prescianotto-Baschong, Anne Spang, Reid Gilmore, Anderson J. R., Andrei M. A., Aronov S., Batiza A. F., Bi J., Bouveret E., Buchan J. R., Chowdhury A., Coller J., Cox J. S., De Filippi L., de la Cruz J., Decker C. J., Decker C. J., Deloche O., Dunckley T., Erdeniz N., Eulalio A., Ferraiuolo M. A., Franks T. M., Geiser J. R., Grousl T., Gueldener U., Hayashi M., Heath V. L., Hohmann S., Hoyle N. P., Kedersha N., Kimata Y., Knop M., Lee K. S., Matsumoto T. K., Nelson K. K., Ohya Y., Parker R., Patil C. K., Prescianotto-Baschong C., Reijns M. A., Romero-Santacreu L., Salgado-Garrido J., Schmelzle T., Schmid M., Sherman F., Sheth U., Sidrauski C., Sikorski R. S., Spang A., Swisher K.D., Teixeira D., Tharun S., Tharun S., Tharun S., Van Wuytswinkel O., Wilczynska Z., Wilhelm J. E.   +59 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Intrinsic tethering activity of endosomal Rab proteins. [PDF]

, 2011
Rab small G proteins control membrane trafficking events required for many processes including secretion, lipid metabolism, antigen presentation and growth factor signaling.
Brett, Christopher L, Fields, Stanley, Gonen, Tamir, Lo, Sheng-Ying, Merz, Alexey J, Plemel, Rachael L, Vignali, Marissa   +6 more
core   +3 more sources