Results 71 to 80 of about 12,764 (213)
CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.
PLoS ONE, 2014 Juvenile Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL) is a devastating neurodegenerative disease caused by mutations in CLN3, a protein of undefined function.
Mark L Schultz +4 more
doaj +1 more source
ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi
Frontiers in Cell and Developmental Biology, 2021 Molecular switches of the ADP-ribosylation factor (ARF) GTPase family coordinate intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi-intermediate compartment (ERGIC) to the plasma membrane (PM).
Petia Adarska +2 more
doaj +1 more source
Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2 [PDF]
, 2014 Preadipocyte migration is vital for the development of adipose tissue, which plays a crucial role in lipid metabolism. ADP-ribosylation factor 6 (ARF6) small GTPase, which regulates membrane trafficking, is activated by GTP-exchange factors (GEFs) such ...
Venkat, Kanamarlapudi
core +1 more source
Arf1 doubles up to release vesicles [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Coatomer and wild-type Arf1 generate COPI vesicles from liposomes (left), but coatomer and dimerization-deficient Arf1 only induce coated vesicle buds (right). The Arf1 GTPase and vesicle coat proteins catalyze distinct steps in the budding and release of COPI vesicles ...
openaire +1 more source
Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. [PDF]
PLoS ONE, 2009 In mammalian cells, endocytosis of the fluid phase and glycosylphosphatidylinositol-anchored proteins (GPI-APs) forms GEECs (GPI-AP enriched early endosomal compartments) via an Arf1- and Cdc42-mediated, dynamin independent mechanism.
Gagan D Gupta +5 more
doaj +1 more source
Drug Testing and Analysis, Volume 18, Issue 4, Page 581-602, April 2026.A two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Daria Obratov +4 more
wiley +1 more source
mBio, 2015 To establish intracellular infections, Salmonella bacteria trigger host cell membrane ruffling and invasion by subverting cellular Arf guanine nucleotide exchange factors (GEFs) that activate Arf1 and Arf6 GTPases by promoting GTP binding.
Anthony C. Davidson +4 more
doaj +1 more source
The inhibitor endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with subcellular trafficking in eukaryotes [PDF]
, 2018 The trafficking of subcellular cargos in eukaryotic cells crucially depends on vesicle budding, a process mediated by ARFGEFs (ADP-ribosylation factor guanine nucleotide exchange factors). In plants, ARF-GEFs play essential roles in endocytosis, vacuolar
Cherfils, Jacqueline +12 more
core +3 more sources
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, Volume 13, Issue 14, 9 March 2026.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
Scientific Reports, 2017 How multicellular organisms maintain immune homeostasis across various organs and cell types is an outstanding question in immune biology and cell signaling.
Rohan J. Khadilkar +6 more
doaj +1 more source