Results 61 to 70 of about 6,923 (171)

From Pits to Plaques: Electron Microscopy Reveals Clathrin Structural Plasticity in Trafficking, Sorting and Adhesion

Traffic, Volume 27, Issue 3, September 2026.
Clathrin plaques (magenta) form large, flat membrane‐associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin‐coated pits (yellow). These structures are surrounded by a dense network of actin filaments and associated proteins, illustrating the intimate structural coupling between clathrin ...
Marion Benoist, Stéphane Vassilopoulos
wiley   +1 more source

Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis

Cell Reports, 2016
To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small ...
Daniel Humphreys, Vikash Singh, Vassilis Koronakis   +2 more
doaj   +1 more source

Architecture of the vimentin cytoskeleton is modified by perturbation of the GTPase ARF1 [PDF]

Journal of Cell Science, 2006
Intermediate filaments are required for proper membrane protein trafficking. However, it remains unclear whether perturbations in vesicular membrane transport result in changes in the architecture of the vimentin cytoskeleton. We find that treatment of cells with Brefeldin A, an inhibitor of specific stages of membrane transport, causes changes in the ...
Melanie L, Styers, Andrew P, Kowalczyk, Victor, Faundez   +2 more
openaire   +2 more sources

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

The Arf GTPase-Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells

mBio, 2015
To establish intracellular infections, Salmonella bacteria trigger host cell membrane ruffling and invasion by subverting cellular Arf guanine nucleotide exchange factors (GEFs) that activate Arf1 and Arf6 GTPases by promoting GTP binding.
Anthony C. Davidson, Daniel Humphreys, Andrew B. E. Brooks, Peter J. Hume, Vassilis Koronakis   +4 more
doaj   +1 more source

ARF1(2–17) does not specifically interact with ARF1‐dependent pathways

FEBS Letters, 1994
The small GTP‐binding protein ARF has been shown recently to regulate phospholipase D (PLD). In order to investigate the role of ARF proteins in regulated exocytosis, we have used the N‐terminal peptide ARF1(2–17) of the ARF1 protein. ARF1 reconstituted PLD activity in cytosol‐depleted HL60 cells was inhibited by ARF1(2–17).
Fensome, Amanda, Cunningham, Emer, Troung, Oanh, Cockcroft, Shamshad   +3 more
openaire   +2 more sources

The Role of ARF1 and Rab GTPases in Polarization of the Golgi Stack [PDF]

Traffic, 2005
The organization and sorting of proteins within the Golgi stack to establish and maintain its cis to trans polarization remains an enigma. The function of Golgi compartments involves coat assemblages that facilitate vesicle traffic, Rab‐tether‐SNAP receptor (SNARE) machineries that dictate membrane identity, as well as matrix components that maintain ...
Serguei I, Bannykh, Helen, Plutner, Jeanne, Matteson, William E, Balch   +3 more
openaire   +2 more sources

circFOXP1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Regulating EREG/MAPK/ERK Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Circular RNAs (circRNAs) are indispensable for triggering pancreatic ductal adenocarcinoma (PDAC) progression. However, the specific biological processes and mechanisms by which circRNAs influence PDAC remain largely unknown. Here, we reported that circFOXP1 is a critical promoter of PDAC progression, exhibiting marked upregulation in patient ...
Leyi Huang, Dan Su, Rihua He, Bingzheng Zhong, Qiang Wang, Fuxu Feng, Jingwen Li, Jie Cao, Quanbo Zhou, Xiaofeng Guo   +9 more
wiley   +1 more source

ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.

PLoS ONE, 2012
BackgroundARF6 (ADP-ribosylation factor 6) small GTP binding protein plays critical roles in actin cytoskeleton rearrangements and membrane trafficking, including internalisation of G protein coupled receptors (GPCR). ARF6 operates by cycling between GDP-
Venkateswarlu Kanamarlapudi, Sian E Owens, Jon Lartey, Andrés López Bernal   +3 more
doaj   +1 more source

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang, Juan Mei, Shuyue Li, Guoan Zhang, Jian Qiu, Xuezhi Li   +5 more
wiley   +1 more source