Results 61 to 70 of about 7,868 (194)
The small GTPase ARF6 regulates GABAergic synapse development
Molecular Brain, 2020 ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim +5 more
doaj +1 more source
Ion Activation Methods for Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head and neck squamous cell carcinoma (
Leilei He +5 more
doaj +1 more source
The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
Frontiers in Cell and Developmental Biology, 2021 Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers.
Kana Fujibayashi, Joji Mima
doaj +1 more source
GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang +5 more
wiley +1 more source
Ectopic expression of 3CD causes activation of Arf1.
, 2018 (A) Schematic of assay used to detect GTP-bound (activated) Arf1. HeLa cells were transfected with or without 3CD mRNA. A lysate was prepared using transfected cells and combined with magnetic beads to which the GGA3 adaptor protein was immobilized. Arf1-
Sravani Banerjee (5150786) +10 more
core +1 more source
CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.
PLoS ONE, 2014 Juvenile Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL) is a devastating neurodegenerative disease caused by mutations in CLN3, a protein of undefined function.
Mark L Schultz +4 more
doaj +1 more source
ARF GTPases and Their Ubiquitous Role in Intracellular Trafficking Beyond the Golgi
Frontiers in Cell and Developmental Biology, 2021 Molecular switches of the ADP-ribosylation factor (ARF) GTPase family coordinate intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi-intermediate compartment (ERGIC) to the plasma membrane (PM).
Petia Adarska +2 more
doaj +1 more source
Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi +4 more
wiley +1 more source
Vps74p controls Golgi size in an Arf1‐dependent manner [PDF]
FEBS Letters, 2018 The oncogene GOLPH3 is implicated in Golgi size regulation, a function yet to be experimentally linked to its PI4P effector function or the Golgi cisternal maturation in general. Moreover, its yeast homolog, Vps74p is not yet implicated in Golgi size regulation.
Prasanna Iyer +4 more
openaire +2 more sources