Results 61 to 70 of about 12,764 (213)
Biological Reviews, EarlyView.ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu +12 more
wiley +1 more source
ARF1-mediated actin polymerization produces movement of artificial vesicles [PDF]
Proceedings of the National Academy of Sciences, 2007 Vesicular trafficking and actin dynamics on Golgi membranes are both regulated by ADP-ribosylation factor 1 (ARF1) through the recruitment of various effectors, including vesicular coats. Actin assembly on Golgi membranes contributes to the architecture of the Golgi complex, vesicle formation, and trafficking and is mediated by ARF1 through a cascade ...
Julien, Heuvingh +3 more
openaire +2 more sources
The small GTPase ARF6 regulates GABAergic synapse development
Molecular Brain, 2020 ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells.
Hyeonho Kim +5 more
doaj +1 more source
The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
Frontiers in Cell and Developmental Biology, 2021 Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers.
Kana Fujibayashi, Joji Mima
doaj +1 more source
Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]
, 2010 The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr +67 more
core +1 more source
Ion Activation Methods for Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head and neck squamous cell carcinoma (
Leilei He +5 more
doaj +1 more source
Structures of Ras superfamily effector complexes: What have we learnt in two decades? [PDF]
, 2015 The Ras superfamily small G proteins are master regulators of a diverse range of cellular processes and act via downstream effector molecules. The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ...
Mott, Helen R, Owen, Darerca
core +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Mutational Analysis of the Arf1•GTP/Arf GAP Interface Reveals an Arf1 Mutant that Selectively Affects the Arf GAP ASAP1 [PDF]
Current Biology, 2005 Arf1 is a GTP binding protein that functions at a number of cellular sites to control membrane traffic and actin remodeling. Arf1 is regulated by site-specific GTPase-activating proteins (GAPs). The combined results of crystallographic and biochemical studies have led to the proposal that Arf1 GAPs differ in the specific interface formed with Arf1.
Luo, Ruibai +5 more
openaire +2 more sources