Results 81 to 90 of about 12,764 (213)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

ARF1(2–17) does not specifically interact with ARF1‐dependent pathways

FEBS Letters, 1994
The small GTP‐binding protein ARF has been shown recently to regulate phospholipase D (PLD). In order to investigate the role of ARF proteins in regulated exocytosis, we have used the N‐terminal peptide ARF1(2–17) of the ARF1 protein. ARF1 reconstituted PLD activity in cytosol‐depleted HL60 cells was inhibited by ARF1(2–17).
Fensome, Amanda, Cunningham, Emer, Troung, Oanh, Cockcroft, Shamshad   +3 more
openaire   +2 more sources

ARF1 compartments direct cargo flow via maturation into recycling endosomes

Nature Cell Biology, 2023
Abstract Cellular membrane homoeostasis is maintained via a tightly regulated membrane and cargo flow between organelles of the endocytic and secretory pathways. Adaptor protein complexes (APs), which are recruited to membranes by the small GTPase ARF1, facilitate cargo selection and incorporation into trafficking intermediates ...
Alexander Stockhammer, Petia Adarska, Vini Natalia, Anja Heuhsen, Antonia Klemt, Gresy Bregu, Shelly Harel, Carmen Rodilla-Ramirez, Carissa Spalt, Ece Oezsoy, Paula Leupold, Alica Grindel, Eleanor Fox, Joy O Mejedo, Amin Zehtabian, Helge Ewers, Dmytro Puchkov, Volker Haucke, Francesca Bottanelli   +18 more
openaire   +3 more sources

Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis

Cell Reports, 2016
To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small ...
Daniel Humphreys, Vikash Singh, Vassilis Koronakis   +2 more
doaj   +1 more source

Comprehensive analysis of the membrane phosphoproteome regulated by oligogalacturonides in Arabidopsis thaliana [PDF]

, 2016
Early changes in the Arabidopsis thaliana membrane phosphoproteome in response to oligogalacturonides (OGs), a class of plant damage-associated molecular patterns (DAMPs), were analyzed by two complementary proteomic approaches.
DE LORENZO, Giulia, MATTEI, Maria Benedetta, PONTIGGIA, Daniela, SPINELLI, FRANCESCO   +3 more
core   +1 more source

B‐GATA factors are required for nitrogen‐responsive growth in Physcomitrium patens and Arabidopsis thaliana

New Phytologist, Volume 249, Issue 6, Page 2919-2937, March 2026.
Summary We hypothesized that B‐GATA family transcription factors have important roles in growth regulation in moss. We analyzed B‐GATA family transcription factor mutants from Physcomitrium patens and Arabidopsis thaliana to assess growth, gene expression, and cytokinin‐related processes under varying nitrogen conditions.
Dario Zappone, Peter Michael Schröder, Ivan Petřík, Xiao Dong, Rudi Schäufele, Korbinian Schneeberger, Ondřej Novák, Claus Schwechheimer   +7 more
wiley   +1 more source

ARF1 Localizes to the Golgi and the Trans-Golgi Network [PDF]

The Plant Cell, 2011
The recruitment of coat proteins for transport vesicles (COPI-, COPII-, and clathrin-coated) is mediated by the small GTPases of the ADP-ribosylation factor (ARF) family of which there are three SAR , 12 ARF , and six ARL genes in the Arabidopsis thaliana genome ([Vernoud et al., 2003][1 ...
Robinson, David G, Scheuring, David, Naramoto, Satoshi, Friml, Jiri   +3 more
openaire   +3 more sources

ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.

PLoS ONE, 2012
BackgroundARF6 (ADP-ribosylation factor 6) small GTP binding protein plays critical roles in actin cytoskeleton rearrangements and membrane trafficking, including internalisation of G protein coupled receptors (GPCR). ARF6 operates by cycling between GDP-
Venkateswarlu Kanamarlapudi, Sian E Owens, Jon Lartey, Andrés López Bernal   +3 more
doaj   +1 more source

Antisense Phenotypes Reveal a Functional Expression of OsARF1, an Auxin Response Factor, in Transgenic Rice [PDF]

, 2009
OsARF1 is the first full-length member of auxin response factor (ARF) gene family to be cloned from monocot plant. Using quantitative RT-PCR this study found that, the transcript abundance of OsARF1 was significantly higher in embryonic tissues than in ...
Abdelkhalik, Amr F, Ammar, Megahed H, Attia, Kotb A., El-Sayed, Wagih M, El-Shemy, Hany A, Lightfoot, David A, Wei, Chun, Yang, Jinshui   +7 more
core   +2 more sources

Elucidating the Genetic Basis of Columnar Upright Architecture in Populus Through CRISPR Disruption of TILLER ANGLE CONTROL1

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1377-1397, March 2026.
ABSTRACT Narrow or upright branch angles in shoots and leaves lead to columnar, upright‐growing tree architectures, as observed in various tree species such as Lombardy poplar (Populus nigra var. italica). However, the genetic mechanism underlying this unique growth habit in Lombardy poplar has not yet been elucidated.
Na‐Young Choi, Min‐Ha Kim, Hyun‐A Jang, Seung‐Won Pyo, Kong‐Young Park, Hyoshin Lee, Eun‐Kyung Bae, Jae‐Heung Ko   +7 more
wiley   +1 more source