Results 81 to 90 of about 7,868 (194)
Cell Reports, 2016 To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small ...
Daniel Humphreys +2 more
doaj +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, Volume 13, Issue 14, 9 March 2026.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
PLoS ONE, 2012 BackgroundARF6 (ADP-ribosylation factor 6) small GTP binding protein plays critical roles in actin cytoskeleton rearrangements and membrane trafficking, including internalisation of G protein coupled receptors (GPCR). ARF6 operates by cycling between GDP-
Venkateswarlu Kanamarlapudi +3 more
doaj +1 more source
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. [PDF]
PLoS Pathogens, 2008 Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic
Monique H Verheije +7 more
doaj +1 more source
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
Med Research, Volume 2, Issue 1, Page 4-21, March 2026.ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
New Phytologist, Volume 249, Issue 6, Page 2919-2937, March 2026.Summary We hypothesized that B‐GATA family transcription factors have important roles in growth regulation in moss. We analyzed B‐GATA family transcription factor mutants from Physcomitrium patens and Arabidopsis thaliana to assess growth, gene expression, and cytokinin‐related processes under varying nitrogen conditions.
Dario Zappone +7 more
wiley +1 more source
Arf1 doubles up to release vesicles [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Coatomer and wild-type Arf1 generate COPI vesicles from liposomes (left), but coatomer and dimerization-deficient Arf1 only induce coated vesicle buds (right). The Arf1 GTPase and vesicle coat proteins catalyze distinct steps in the budding and release of COPI vesicles ...
openaire +1 more source
, 2008 Die kleine GTPase Arf1 übernimmt eine zentrale Rolle während der COPI Vesikel- Biogenese. Im inaktiven, Arf1-GDP Zustand liegt Arf1 überwiegend als lösliches Protein im Cytosol vor.
Anderl, Frank
core +1 more source
Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation
Cell Reports, 2016 Lipogenesis requires coordinated expression of genes for fatty acid, phospholipid, and triglyceride synthesis. Transcription factors, such as SREBP-1 (Sterol regulatory element binding protein), may be activated in response to feedback mechanisms linking
Lorissa J. Smulan +5 more
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 3, Page 1377-1397, March 2026.ABSTRACT Narrow or upright branch angles in shoots and leaves lead to columnar, upright‐growing tree architectures, as observed in various tree species such as Lombardy poplar (Populus nigra var. italica). However, the genetic mechanism underlying this unique growth habit in Lombardy poplar has not yet been elucidated.
Na‐Young Choi +7 more
wiley +1 more source