Results 81 to 90 of about 6,923 (171)

TAMs-specific ARF1 inhibition reprograms glioma microenvironment and enhances the therapeutic effect of oncolytic adenovirus

iScience
Summary: Gliomas, characterized by their robust immunosuppressive microenvironment, pose a significant challenge to the efficacy of immunotherapies. The cGas/STING signaling pathway is emerging as a promising target for cancer immunotherapy.
Tao Cao, Tong Hao, Xiaoru Zhang, Bo Chen, Hongxuan Zhang, Luocheng Shao, Wenqiao He, Bingnan Li, Qihao Zheng, Peng Ji, Ke Tao   +10 more
doaj   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

eLife, 2017
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane ...
Svetlana O Dodonova, Patrick Aderhold, Juergen Kopp, Iva Ganeva, Simone Röhling, Wim J H Hagen, Irmgard Sinning, Felix Wieland, John A G Briggs   +8 more
doaj   +1 more source

miR‐744‐5p inhibits cellular proliferation and invasion via targeting ARF1 in epithelial ovarian cancer

Kaohsiung Journal of Medical Sciences, 2020
miR‐744‐5p has been demonstrated to play an important role in cancer progression. However, the functions of miR‐744‐5p in epithelial ovarian cancer (EOC) are not well clarified.
Lai‐Gang Zhao, Jiao Wang, Jin Li, Qin‐Fen Li   +3 more
doaj   +1 more source

Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts

Biology Open, 2023
Rajeshwari B.R., Nikita Shah, Prachi Joshi, M. S. Madhusudan, Nagaraj Balasubramanian   +4 more
doaj   +1 more source

ARF1 Frequency and Amplitude Curve Calibration [PDF]

, 2001
ARF1 was calibrated and checked on 4/18/01. The technique used was to set the start/stop timers (A:R1LLT1 and A:R1LLT2) for duration of 200 msec. Driving the cavities for longer than 200 msec at full voltage could put some stress on the Hipotronics anode supply. The Camac curve generator card was substituted with a precision DC voltage source. Data for
openaire   +2 more sources

ARF1 -related disorder:Phenotypic and molecular spectrum

, 2023
Purpose ARF1 was previously implicated in periventricular nodular heterotopia (PVNH) in only five individuals and systematic clinical characterisation was not available. The aim of this study is to provide a comprehensive description of the phenotypic and genotypic spectrum of ARF1-related neurodevelopmental disorder.
De Sainte Agathe,Jean Madeleine, Pode-Shakked,Ben, Naudion,Sophie, Michaud,Vincent, Arveiler,Benoit, Fergelot,Patricia, Delmas,Jean, Keren,Boris, Poirsier,Céline, Alkuraya,Fowzan S., Tabarki,Brahim, Bend,Eric, Davis,Kellie, Bebin,Martina, Thompson,Michelle L., Bryant,Emily M., Wagner,Matias, Hannibal,Iris, Lenberg,Jerica, Krenn,Martin, Wigby,Kristen M., Friedman,Jennifer R., Iascone,Maria, Cereda,Anna, Miao,Térence, Leguern,Eric, Argilli,Emanuela, Sherr,Elliott, Caluseriu,Oana, Tidwell,Timothy, Bayrak-Toydemir,Pinar, Hagedorn,Caroline, Brugger,Melanie, Vill,Katharina, Morneau-Jacob,Francois Dominique, Chung,Wendy, Weaver,Kathryn N., Owens,Joshua W., Husami,Ammar, Chaudhari,Bimal P., Stone,Brandon S., Burns,Katie, Li,Rachel, De Lange, Iris M., Biehler,Margaux, Ginglinger,Emmanuelle, Gérard,Bénédicte, Stottmann,Rolf W., Trimouille,Aurélien, Child Health, Genetica Oper.Mang. Clinical Genetics   +50 more
openaire   +1 more source

Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.

PLoS ONE
The ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with myristate.
Eric M Rosenberg, Xiaoying Jian, Olivier Soubias, Rebekah A Jackson, Erin Gladu, Emily Andersen, Lothar Esser, Alexander J Sodt, Di Xia, R Andrew Byrd, Paul A Randazzo   +10 more
doaj   +1 more source

Parvovirus B19 and Human Parvovirus 4 Encode Similar Proteins in a Reading Frame Overlapping the VP1 Capsid Gene

Viruses
Viruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet, overlapping genes are often overlooked during genome annotation, in particular in DNA viruses.
David G. Karlin
doaj   +1 more source

Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity

Advanced Science
The small G protein Arf1 has been identified as playing a selective role in supporting cancer stem cells (CSCs), making it an attractive target for cancer therapy.
Yuetong Wang, Qiaoming Li, Yahui Ding, Chenfei Luo, Jun Yang, Na Wang, Ning Jiang, Tiange Yao, Guohao Wang, Guoming Shi, Steven X. Hou   +10 more
doaj   +1 more source