Results 101 to 110 of about 7,868 (194)
Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts
Biology Open, 2023 Rajeshwari B.R. +4 more
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Comparison of [L8K]Arf1 crystal structure with human and yeast Arf1 structures.
(A) Crystal structure of [L8K]Arf1 in complex with guanosine-3’-monophosphate-5’-diphosphate (G3D). N- and C-termini, G domain motifs, and magnesium ion are labeled. Part of switch II could not be modeled and is depicted with dashed lines.
R. Andrew Byrd (2463943) +10 more
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ARF1-GTP is reduced in CLN3-null MBECs.
, 2014 (A) ARF1-GTP levels were quantified in Cln3R and Cln3−/− MBEC lysates. (B) Total ARF1 protein levels were quantified in Cln3R and Cln3−/− MBEC lysates by western blot, expressed as band intensity normalized to the actin loading control.
Mark A. Stamnes (558606) +4 more
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PLoS ONEThe ADP-ribosylation factors (Arfs) constitute a family of small GTPases within the Ras superfamily, with a distinguishing structural feature of a hypervariable N-terminal extension of the G domain modified with myristate.
Eric M Rosenberg +10 more
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VirusesViruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet, overlapping genes are often overlooked during genome annotation, in particular in DNA viruses.
David G. Karlin
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The exploration of ARF1 screening assays to determine the drug status of ARF1 in cancer and malaria
, 2020 ARF GTPases are key regulators of the secretory and endocytic pathways. ARF1 is involved in the secretory pathway. ARF1 has been implicated in the endoplasmic reticulum to Golgi transport, function of the Golgi apparatus and transport from the trans ...
Ntlantsana, Apelele
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(A) Comparison of the positions of residues within the N-terminal extensions of non-myristoylated WT Arf1•GDP (left) and [L8K]Arf1•G3D (middle). An overlay of the two structures is shown on the right, with arbitrary labels for the positions of the amino ...
R. Andrew Byrd (2463943) +10 more
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ArfGAP1 generates an Arf1 gradient on continuous lipid membranes displaying flat and curved regions.
, 2010 International audienceArfGAP1, which promotes GTP hydrolysis on the small G protein Arf1 on Golgi membranes, interacts preferentially with positively curved membranes through its amphipathic lipid packing sensor (ALPS) motifs.
Bassereau, Patricia +5 more
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Exploring the role of ADP-ribosylation factor 1 (Arf1) in tunneling nanotube formation
, 2023 Tunneling nanotubes (TNTs) are cellular protrusions used for direct communication and transfer of material between cells. However, numerous infectious agents like HIV, COVID-19, and prions are known to spread using TNTs, so inhibiting TNT formation could
Daniel Savala
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