Results 101 to 110 of about 12,764 (213)

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

ARF1 Frequency and Amplitude Curve Calibration [PDF]

, 2001
ARF1 was calibrated and checked on 4/18/01. The technique used was to set the start/stop timers (A:R1LLT1 and A:R1LLT2) for duration of 200 msec. Driving the cavities for longer than 200 msec at full voltage could put some stress on the Hipotronics anode supply. The Camac curve generator card was substituted with a precision DC voltage source. Data for
openaire   +2 more sources

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation

Cell Reports, 2016
Lipogenesis requires coordinated expression of genes for fatty acid, phospholipid, and triglyceride synthesis. Transcription factors, such as SREBP-1 (Sterol regulatory element binding protein), may be activated in response to feedback mechanisms linking
Lorissa J. Smulan, Wei Ding, Elizaveta Freinkman, Sharvari Gujja, Yvonne J.K. Edwards, Amy K. Walker   +5 more
doaj   +1 more source

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Oncotarget, 2016
ADP-ribosylation factor 1 (ARF1) is a crucial regulator in vesicle-mediated membrane trafficking and involved in the activation of signaling molecules. However, virtually nothing is known about its function in prostate cancer. Here we have demonstrated that ARF1 expression is significantly elevated in prostate cancer cells and human tissues and that ...
Davis, Jason E., Xie, Xiayang, Guo, Jianhui, Huang, Wei, Chu, Wen-Ming, Huang, Shuang, Teng, Yong, Wu, Guangyu   +7 more
openaire   +2 more sources

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

Exploring the Neuroprotective Promise of Functional Fruit Phytochemicals

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Neurodegenerative diseases, including Alzheimer’s disease, represent a significant global clinical challenge, since existing treatments primarily manage symptoms rather than addressing the complex and multifactorial underlying pathologies. Functional fruits, including both their edible and nonedible parts, are rich in bioactive phytochemicals such as ...
Tebalelo Lehlaleroa, Chika I. Chukwuma, Muriel Mari, Samson S. Mashele, Claudia Ntsapi, Anupama Bose   +5 more
wiley   +1 more source

9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

eLife, 2017
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane ...
Svetlana O Dodonova, Patrick Aderhold, Juergen Kopp, Iva Ganeva, Simone Röhling, Wim J H Hagen, Irmgard Sinning, Felix Wieland, John A G Briggs   +8 more
doaj   +1 more source

Molecular genetics of auxin signaling [PDF]

, 2002
The plant hormone auxin is a simple molecule similar to tryptophan, yet it elicits a diverse array of responses and is involved in the regulation of growth and development throughout the plant life cycle.
Leyser, O
core   +1 more source

The Role of the C3a‐C3aR Pathway in Diseases: Latest Research Advances

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
C3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR). The C3a‐C3aR pathway not only plays an important role in immune regulation but is also closely related to the occurrence and development of various inflammatory diseases, cardiovascular
Xiangwei Bo, Mi Wang, Yang Liu, Yong Zhong, Andari Sarasati   +4 more
wiley   +1 more source