Results 111 to 120 of about 204,238 (313)

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics

International Journal of Nanomedicine, 2019
James G Shamul,1,2,* Sagar R Shah,1–3,* Jayoung Kim,1,2 Paula Schiapparelli,3 Carla A Vazquez-Ramos,3 Ben J Lee,1,2 Kisha K Patel,1,2 Alyssa Shin,1,2 Alfredo Quinones-Hinojosa,3 Jordan J Green1,2,4–6 1Department of Biomedical Engineering ...
Shamul JG, Shah SR, Kim J, Schiapparelli P, Vazquez-Ramos CA, Lee BJ, Patel KK, Shin A, Quinones-Hinojosa A, Green JJ   +9 more
doaj  

Danthron Induced Apoptosis Through Mitochondria- and Caspase-3-Dependent Pathways in Human Brain Glioblastoma Multiforms GBM 8401 Cells [PDF]

, 2010
[[abstract]]Danthron (1,8-dihydroxyanthraquinone), is one of component from Rheum palmatum L. (Polygonaceae), has been shown several biological activities but did not show to induce apoptosis in human brain tumor cells.
Lu, HF (Lu, Hsu-Feng); Wang, HL (Wang, Hai-Lung); Chuang, YY (Chuang, Ying-Ying); Tang, YJ (Tang, Yih-Jing); Yang, JS (Yang, Jai-Sing); Ma, YS (Ma, Yi-Shih); Chiang, JH (Chiang, Jo-Hua); Lu, CC (Lu, Chi-Cheng); Yang, JL (Yang, Jiun-Long); Lai, TY (Lai, Tung-Yuan); Wu, CC (Wu, Chih-Chung); Chung, JG (Chung, Jing-Gung)
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

A Joint Fermi-GBM and Swift-BAT Analysis of Gravitational-wave Candidates from the Third Gravitational-wave Observing Run

We present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational-wave (GW) candidate events identified during the third observing run of the Advanced LIGO and ...
Barone, F., Bobba, F., Acernese, F., Kagra, Collaboration, Troiano, L., Granata, V., Cannavacciuolo, M., Fittipaldi, R., Durante, O., Chiadini, F., LIGO Scientific, Collaboration, De Simone, R., Di Giorgio, C., Romano, R., Swift-BAT, Collaboration, Virgo, Collaboration, Carapella, G., Fermi-GBM, Collaboration   +17 more
core   +1 more source

Survival for GBM patients.

, 2016
Survival curves of GBM patients with and without aberrations in feature selected 8-gene set (A), 16 gene IRGS (B), and full 61 gene set (C). In all cases, we fail to reject the null hypothesis of survival curve equivalence, suggesting that the of role ...
Cody Weston (3369017), Joe Klobusicky (3369014), James Connor (291893), Steven A. Toms (3369020), Nicholas F. Marko (123844), Jennifer Weston (3369011)   +5 more
core   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines. [PDF]

, 2016
Human tumor cell lines form the basis of the majority of present day laboratory cancer research. These models are vital to studying the molecular biology of tumors and preclinical testing of new therapies. When compared to traditional adherent cell lines,
Amin B Kassam, Alessandro Olivi (471259), I-Mei Siu, Charles G. Eberhart (150132), Siu, I-Mei, Vafi Salmasi, Chetan Bettegowda (79774), Jon D Weingart, Henry Brem, Alfredo Quinones-Hinojosa, Alfredo Quinones-Hinojosa (154292), Gregory J Riggins, I-Mei Siu (130150), Chetan Bettegowda, Amin B. Kassam (780587), Orr, Brent A, Michael Lim (596800), Vafi Salmasi (2583430), Zev A Binder, Eberhart, Charles G, Gregory J. Riggins (130159), Binder, Zev A, Gallia, Gary L, Kelli M Wilson, Zev A. Binder (471251), Salmasi, Vafi, Michael Lim, Henry Brem (596798), Lim, Michael, Alessandro Olivi, Riggins, Gregory J, Gary L Gallia, Brem, Henry, Jon D. Weingart (471258), Kelli M. Wilson (2583427), Brent A. Orr (150119), Bettegowda, Chetan, Brent A Orr, Olivi, Alessandro, Gary L. Gallia (130156), Weingart, Jon D, Charles G Eberhart, Quinones-Hinojosa, Alfredo, Kassam, Amin B, Wilson, Kelli M   +44 more
core   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source