Results 131 to 140 of about 204,238 (313)
CD97 is expressed in primary GBM cultures and GBM cell lines.
, 2013 Five low passage primary GBM cultures and three GBM cell lines were analyzed. The five primary GBM cell lines, each isolated and cultured from a tumor resected at our institution, expressed moderate to high levels of CD97, suggesting that expression is ...
Gurvinder Kaur (301991) +10 more
core +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis
, 2015 Wei-kang Xing,1 Chuan Shao,2 Zhen-yu Qi,1 Chao Yang,1 Zhong Wang1 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 2Department of Neurosurgery, The Second Clinical Medical College of North Sichuan ...
Qi ZY, Xing WK, Yang C, Wang Z, Shao C
core
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Advanced Science, EarlyView.Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang +11 more
wiley +1 more source
, 2013 (A) A network view of GBM Module 2 using only direct relationships, drawn by Cytoscape [70]. Genes were grouped together based on the overlap with BioCarta pathways, and the percentages of samples with CNAs and GE changes are shown. CGC genes are colored
A. K. M. Azad (442132) +1 more
core +1 more source
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source
Scientific ReportsAn assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics.
Valeria Cerina +7 more
doaj +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
, 2012 Glioblastoma (GBM) is the most common and aggressive form of primary malignant brain cancer. Treatment options are limited due to tumour heterogeneity and invasive phenotype. In order to develop more effective therapies, molecular characterisation of the
Monika Agnieszka Jarzabek (7959197)
core +1 more source