Results 141 to 150 of about 204,238 (313)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Tumor-infiltrating CD8+ sub-populations in primary and recurrent glioblastoma: An in-silico study

Heliyon
Background: Glioblastoma multiforme (GBM) remains an incurable primary brain tumor. CD8+ tumor-infiltrating lymphocytes (TILs) can target malignant cells; however, their anti-tumoral immune responses mostly do not lead to GBM rejection in GBM patients ...
Mahdi Abdoli Shadbad, Adib Miraki Feriz, Behzad Baradaran, Hossein Safarpour   +3 more
doaj   +1 more source

Network modules identified in GBM.

, 2013
(A) Modules are densely connected sets of altered genes that may reflect oncogenic processes. A total of 10 modules were identified, the largest of which are shown.
Barry S. Taylor (228490), Chris Sander (1345), Emek Demir (367085), Nikolaus Schultz (169137), Ethan Cerami (38316)   +4 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Multimodal analysis of glioblastoma reveals the potential of cxcr7-cxcl12 in gbm cells sensitizes gbm to immune checkpoint blockade therapy

[[abstract]]BACKGROUND: Glioblastoma (GBM), a WHO Grade IV glioma, is one of the most lethal brain tumors. In spite of the standard of care and currently developed advanced treatment, the prognosis of GBM patients is still poor.
Liu, C;Chien, C;Yang, W;Chuang, J;Chang, K
core   +1 more source

Fermi GBM: Results from the First Year + [PDF]

, 2009
Gamma-ray Burst Monitor (GBM) has performed well in the first year+. GBM triggers 353 Gamma-ray Bursts (GRBs), 168 SGR events, 18 TGFs, and 1 solar flare to date. Short GRBs appear contracted in time and shifted to higher energy than long GRBs.
Wilson-Hodge, Colleen A.
core  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

STK17A is overexpressed in GBM.

, 2013
A, Data from Sun Brain [19], and TCGA Brain (https://tcga-data.nci.nih.gov/tcga/tcgaHome2.jsp) comparing microarray-based STK17A expression from clinical nonmalignant brain specimens (Norm.
Pingping Mao (490859), Bijesh Biswal (490863), Eric Yang (243148), Michael J. Spinella (109108), Mary P. Hever-Jardine (109093), Mark A. Israel (490865), Anita Kodali (490862), Arti Gaur (490864), Camilo E. Fadul (114252), Janice Tam (490861), Gilbert J. Rahme (490860)   +10 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Anti-GBM glomerulonephritis / Nabia Idaam Mustapa Albakari [PDF]

, 2018
Anti- GBM is a rare, life-threatening disease, which characterized by production of auto antibodies towards glomerular membrane. It is diagnosed by high presence of anti­ GBM in blood and renal biopsy finding.
Mustapa Albakari, Nabia Idaam
core