Results 161 to 170 of about 204,238 (313)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Effective methods for increasing levels of political self‐efficacy for girls and disadvantaged students in England

British Educational Research Journal, EarlyView.
Abstract This study addresses the gap in rigorous evaluation of inclusive Citizenship Education methods in reducing gender and socioeconomic inequalities in political self‐efficacy. This article tests the effectiveness of two pedagogical approaches: counter‐narratives and think‐pair‐share.
Bryony Hoskins, Khuyen Dinh, Christian Christrup Kjeldsen   +2 more
wiley   +1 more source

Overall Survival Predictions of GBM Patients Using Radiomics: An Explainable AI Approach Using SHAP

Glioblastoma multiforme (GBM) is a WHO grade IV tumor and its heterogeneity pushes oncologists to focus on more personalized treatments for individual patients. This challenge is aided by radiomics, which involves the extraction of valuable features from
Walgampaya, CK, Alawatugoda, Janaka, A. M. H. H. Alahakoon, C. K. Walgampaya, Alahakoon, AMHH, Walgampaya, Shyama, Ekanayake, IU, Shyama Walgampaya, I. U. Ekanayake, Janaka Alawatugoda   +9 more
core   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

A GBM by Any Other Name? [PDF]

Brain Pathology, 2008
openaire   +2 more sources

Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells

, 2012
[[abstract]]Danthron (1,8-dihydroxyanthraquinone), is one of component from Rheum palmatum L. (Polygonaceae), has been shown several biological activities but did not show to induce apoptosis in human brain tumor cells.
呂旭峰;Lu, Hsu-Feng;Wang, Hai-Lung;Chuang, Ying-Ying;Tang, Yih-Jing;楊家欣;Yang, Jai-Sing;Ma, Yi-Shih;江若華;Chiang, Jo-Hua;呂啟誠;Lu, Chi-Cheng;楊鈞隆;Yang, Jiun-Long;賴東淵;Lai, Tung-Yuan;Wu, Chih-Chung;鍾景光;Chung, Jing-Gung
core  

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

NTAN1 Promotes Glioblastoma Malignant Progression and Is a Novel Prognostic Factor of Poor Prognosis. [PDF]

Biomedicines
Yang J, Lin Z, Wang Z, Lin S, Chen M, Xu H, Lv Q, Gao L, Ge J.   +8 more
europepmc   +1 more source