Results 251 to 260 of about 204,238 (313)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study. [PDF]

J Clin Med
Gromadzki B, Wiciński M, Siedlecki Z, Porzych R, Pisarski I.   +4 more
europepmc   +1 more source

Tumor-neuronal hybrid programs reveal a spatially adaptive malignant state in glioblastoma. [PDF]

Front Oncol
Yuan C, Chen JY.
europepmc   +1 more source

Metabolic cell competition in the glioblastoma tumour microenvironment: glucose, glutamine, and lactate as determinants of immune exclusion and targets for pharmacological reprogramming. [PDF]

Front Oncol
Omene E.
europepmc   +1 more source

The silent consequence of overdose: The case for brain injury‐informed opioid treatment

Addiction, EarlyView.
Nathaniel Day, Kym Kaufmann, Mauricio Garcia‐Barrera, Jitender Sareen, Daniel Vigo   +4 more
wiley   +1 more source

Glioblastoma as Developmental Stress Boundary Displacement: Insect Embryonic Cells as Quantitative Reference Platforms for Mitochondrial Adaptation-A Conceptual Framework. [PDF]

Cells
Rzeski W.
europepmc   +1 more source

Association Between Temozolomide Resistance and Long Non-Coding RNA Expression Profiles in Glioblastoma Cell Lines. [PDF]

Pharmaceuticals (Basel)
Hudáková Z, Hudák Ľ, Hatoková Z, Račay P, Hatok J.   +4 more
europepmc   +1 more source

Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications. [PDF]

NPJ Precis Oncol
Hill CM, Nwagwu CD, Odukoya AO, Hsueh B, Wang AZ, Dunn GP.   +5 more
europepmc   +1 more source

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Seeing the GBM diversity spectrum

Nature Cancer, 2021
The complexity of glioblastoma is becoming increasingly recognized. Three recent studies used single-cell approaches that integrate cellular states, transcriptional trajectories, and metabolic alterations to uncover multiple dimensions of cellular and molecular heterogeneity and provide a framework for additional functional investigation and ...
Christopher G. Hubert, Justin D. Lathia
openaire   +2 more sources

Immune checkpoint inhibitors in GBM

Journal of Neuro-Oncology, 2021
The purpose of this review is to summarize recent updates regarding immune checkpoint inhibitor therapy in GBM patients including updates in brain immunology, clinical trials, mechanisms of resistance, and biomarkers of response.PubMed was searched to identify recent relevant articles on immune checkpoint inhibitor therapy as it pertains to GBM ...
openaire   +2 more sources