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Current Status of the GBM Project
AIP Conference Proceedings, 2007One of the scientific goals of the Large‐Area Telescope (LAT) on GLAST is the study of gamma‐ray bursts (GRBs) in the energy range from ∼20 MeV to ∼300 GeV. In order to extend the energy measurement towards lower energies a secondary instrument, the GLAST Burst Monitor (GBM), will measure GRBs from ∼10 keV to ∼30 MeV and will therefore allow the ...
Lichti, G. +13 more
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Prostaglandins & Other Lipid Mediators, 2018
The World Health Organization classifies glioblastoma (GBM) as a grade IV astrocytoma. Despite the advances in chemotherapy, surgery, and radiation treatments that improve a patient's length of survival, the overall trajectory of the disease remains unchanged. GBM cells produce significant levels of various types of bioactive lipids.
Matthew Thomas, Ferreira +5 more
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The World Health Organization classifies glioblastoma (GBM) as a grade IV astrocytoma. Despite the advances in chemotherapy, surgery, and radiation treatments that improve a patient's length of survival, the overall trajectory of the disease remains unchanged. GBM cells produce significant levels of various types of bioactive lipids.
Matthew Thomas, Ferreira +5 more
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The validity of EORTC GBM prognostic calculator on survival of GBM patients in the West of Scotland
British Journal of Neurosurgery, 2013It is now accepted that the addition of temozolomide to radiotherapy in the treatment of patients with newly diagnosed glioblastoma multiforme (GBM) significantly improves survival. In 2008, a subanalysis of the original study data was performed, and an online "GBM Calculator" was made available on the European Organisation for Research and Treatment ...
Mario, Teo +5 more
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The Importance of Mutational Drivers in GBM
Critical Reviews in Eukaryotic Gene Expression, 2016Glioblastoma (GBM) is the most aggressive primary brain tumor, providing few effective therapeutic options, given the tumor heterogeneity and the accumulation of different genetic abnormalities that cause treatment failure. The many different genetic and epigenetic alterations present in GBM lead to modification of several major signaling pathways ...
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BMJ Case Reports
We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby.
Abdul Hadi, Kafagi +3 more
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We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby.
Abdul Hadi, Kafagi +3 more
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GBM Immunotherapy: Macrophage Impacts
Immunological InvestigationsGlioblastoma (GBM) is an extremely aggressive form of brain tumor with low survival rates. Current treatments such as chemotherapy, radiation, and surgery are problematic due to tumor growth, invasion, and tumor microenvironment. GBM cells are resistant to these standard treatments, and the heterogeneity of the tumor makes it difficult to find a ...
Nina Loginova +4 more
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“Atypical” Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All?
American Journal of Kidney DiseasesTwo large cohorts1,2 of patients with “atypical” anti–glomerular basement membrane (GBM) disease sharedheterogeneous clinical presentations and a single commoninclusioncriterion—linearIgGstainingalongthe GBM, foundonbiopsy. Indeed,4patientsevendemonstratedanti-GBMantibodies, deemedrelevantforthediagnosisof“typical”anti-GBMdis ease ...
Vanja Ivković +2 more
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Hypoxia Is the Driving Force Behind GBM and Could Be a New Tool in GBM Treatment
Critical Reviews in Eukaryotic Gene Expression, 2015Glioblastoma (GBM) can be divided into two distinct disease entities according to the genetic and the epigenetic background of the tumor. Tumor location is associated with high variability in its genetic abnormalities. The treatment procedures for these tumors are often unsuccessful because of the cellular heterogeneity and intrinsic ability of the ...
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2015
Abstract Central nervous system (CNS) malignancies vary widely in their morphological and clinical characteristics, the varying patient groups affected, as well as in terms of outcome. Of all the CNS malignancies, glioblastoma multiforme (GBM) is arguably the most devastating.
Eliot Sims, Kathryn Tarver
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Abstract Central nervous system (CNS) malignancies vary widely in their morphological and clinical characteristics, the varying patient groups affected, as well as in terms of outcome. Of all the CNS malignancies, glioblastoma multiforme (GBM) is arguably the most devastating.
Eliot Sims, Kathryn Tarver
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Extracellular matrix in pediatric GBM
2004Purpose: In the last few decades, multiple studies have been addressed at assessing specific factors related to glioblastoma multiforme (GBM) invasion. However, few studies have evaluated the interaction of tumor cells with specific extracellular matrix (ECM) components; moreover, there is a lack of information regarding the occurrence of these ...
CAFFO, Maria +5 more
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