Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY [PDF]
Redox Biology, 2021 Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in the glucokinase (GCK) gene. The low incidence of vascular complications in GCK-MODY makes it a natural paradigm for interrogating molecular ...
Xinhua Xiao, Huabing Zhang, Miao Yu
exaly +4 more sources
GCK‐MODY in pregnancy: A pregnant woman with diabetes and a small‐for‐gestational‐age fetus [PDF]
Clinical Case Reports (discontinued), 2022 Glucokinase‐maturity‐onset diabetes of the young (GCK‐MODY) is often misdiagnosed as other forms of diabetes. A 42‐year‐old pregnant lady with pre‐existing diabetes was treated with insulin during first trimester. Fetal growth restriction was noted since
Ma Rcw, Stephanie C Y Yu
exaly +3 more sources
GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY [PDF]
Frontiers in Genetics, 2023 Objective: Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase (GCK) gene.
Tongtong Dai +14 more
exaly +4 more sources
Distinguishing the lipid profile of GCK-MODY patients and its correlation with hsCRP levels [PDF]
Frontiers in Endocrinology, 2022 AimsGlucokinase–maturity-onset diabetes of the young (GCK-MODY) is the most common monogenic diabetes in China. We have previously reported on the low levels of high-sensitivity C-reactive protein (hsCRP) in patients with GCK-MODY.
Fan Ping, Junling Fu, Xinhua Xiao
doaj +2 more sources
GCK‐MODY、HNF1A‐MODY和2型糖尿病的基础辅助检查的见解:一项系统回顾和meta分析 [PDF]
Journal of Diabetes, 2023 Background Glucokinase maturity‐onset diabetes of the young (GCK‐MODY) is difficult to distinguish from other diabetic forms. This article aims to characterize the differences in results from routine examinations between GCK‐MODY and hepatocyte nuclear ...
Jing Liu +3 more
doaj +2 more sources
Course of pregnancy and 10-year observation of twins diagnosed with GCK-MODY in the neonatal period: a case report [PDF]
Frontiers in EndocrinologyMonogenic diabetes accounts for 5% of all incidence of hyperglycemia and Maturity Onset Diabetes of the Young (MODY) is the most common form. In GCK-MODY, one of the most common forms of MODY, hyperglycemia is caused by a mutation of a gene responsible ...
Barbara Katra +3 more
doaj +2 more sources
Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY) [PDF]
BMC Pediatrics, 2018 Background There is scarcity of information on the clinical features and genetics of glucokinase-maturity-onset diabetes of the young (GCK-MODY) in China.
Xiuzhen Li +8 more
doaj +2 more sources
Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report [PDF]
Frontiers in EndocrinologyBackgroundManagement of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy can be challenging.Case presentationWe present the case report of a 33-year-old woman, diagnosed with diabetes since the age of 9.
Ana Filipa Bolas +12 more
doaj +2 more sources
“Pesto” Mutation: Phenotypic and Genotypic Characteristics of Eight GCK/MODY Ligurian Patients [PDF]
International Journal of Molecular Sciences, 2023 Renata Bocciardi +2 more
exaly +2 more sources
Case Report: A novel likely pathogenic GCK variant in a young Chinese girl with severe insulin resistance [PDF]
Frontiers in EndocrinologyObjectiveTo report a novel GCK variant (c.263T>C) identified in a patient with glucokinase-maturity-onset diabetes of the young (GCK-MODY) and to evaluate its pathogenicity and potential structural impact using in silico analyses.
Haoyu Bai +6 more
doaj +2 more sources