Results 1 to 10 of about 31,450 (226)
Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets [PDF]
Scientific Reports, 2017 Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood.
Tomoko Okuyama +7 more
doaj +3 more sources
Glucokinase and glucokinase activator
Life Metabolism, 2023 Abstract Glucokinase (GK) plays a pivotal role in glucose homeostasis as the glucose sensor in the pancreas and liver. Loss of function of GK results in hyperglycemia, and gain of function causes congenital hyperinsulinemic hypoglycemia.
Li, Changhong +3 more
openaire +1 more source
Molecules, 2021 Glucokinase activators are considered as new therapeutic arsenals that bind to the allosteric activator sites of glucokinase enzymes, thereby maximizing its catalytic rate and increasing its affinity to glucose. This study was designed to identify potent
Kolade Olatubosun Faloye +11 more
doaj +1 more source
Molecular Metabolism, 2023 Objectives: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associates ...
Brian E. Ford +11 more
doaj +1 more source
Molecular Metabolism, 2021 Objective: While the molecular events controlling insulin secretion from β-cells have been documented in detail, the exact mechanisms governing glucagon release by α-cells are understood only partially.
Varun Bahl +4 more
doaj +1 more source
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. [PDF]
PLoS ONE, 2014 Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importance ...
Derek M Erion +21 more
doaj +1 more source
Characterization of a novel glucokinase activator in rat and mouse models. [PDF]
PLoS ONE, 2014 Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate. Glucokinase activators are being investigated as potential diabetes therapies because of their effects on hepatic glucose output and/or insulin
Min Lu +13 more
doaj +1 more source
GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY
Frontiers in Genetics, 2023 Objective: Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase (GCK) gene.
Tongtong Dai +14 more
doaj +1 more source
Evolution of glucose utilization: Glucokinase and glucokinase regulator protein [PDF]
Molecular Phylogenetics and Evolution, 2014 Glucose is an essential nutrient that must be distributed throughout the body to provide energy to sustain physiological functions. Glucose is delivered to distant tissues via be blood stream, and complex systems have evolved to maintain the levels of glucose within a narrow physiological range.
David M, Irwin, Huanran, Tan
openaire +2 more sources
A glucokinase-linked sensor in the taste system contributes to glucose appetite
Molecular Metabolism, 2022 Objectives: Dietary glucose is a robust elicitor of central reward responses and ingestion, but the key peripheral sensors triggering these orexigenic mechanisms are not entirely known.
Sandrine Chometton +6 more
doaj +1 more source