Results 1 to 10 of about 17,223 (183)

Morning glucagon disrupts insulin induced hepatic metabolic memory and subsequent afternoon glucose metabolism in canines [PDF]

Frontiers in Endocrinology
IntroductionThe Staub-Traugott effect, or second-meal phenomenon, describes improved glucose disposal after a second identical meal. We previously showed that morning hyperinsulinemia primes the liver to enhance afternoon net hepatic glucose uptake and ...
Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey, Karin J. Bosma, Richard M. O’Brien, Derek P. Claxton, Tristan Howard, Guillaume Kraft, Alan D. Cherrington, Dale S. Edgerton   +10 more
doaj   +2 more sources

Elucidating the Glucokinase Activating Potentials of Naturally Occurring Prenylated Flavonoids: An Explicit Computational Approach

Molecules, 2021
Glucokinase activators are considered as new therapeutic arsenals that bind to the allosteric activator sites of glucokinase enzymes, thereby maximizing its catalytic rate and increasing its affinity to glucose. This study was designed to identify potent
Kolade Olatubosun Faloye, Boris Davy Bekono, Emmanuel Gabriel Fakola, Marcus Durojaye Ayoola, Oyenike Idayat Bello, Oluwabukunmi Grace Olajubutu, Onikepe Deborah Owoseeni, Shafi Mahmud, Mohammed Alqarni, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Ahmad J. Obaidullah   +11 more
doaj   +1 more source

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326

Molecular Metabolism, 2023
Objectives: The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables acute regulation of liver glucokinase to support metabolic demand. The common human GCKR rs1260326:Pro446 > Leu variant within a large linkage disequilibrium region associates ...
Brian E. Ford, Shruti S. Chachra, Katrina Rodgers, Tabassum Moonira, Ziad H. Al-Oanzi, Quentin M. Anstee, Helen L. Reeves, Jörn M. Schattenberg, Rebecca J. Fairclough, David M. Smith, Dina Tiniakos, Loranne Agius   +11 more
doaj   +1 more source

The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. [PDF]

PLoS ONE, 2014
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importance ...
Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn   +21 more
doaj   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY

Frontiers in Genetics, 2023
Objective: Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase (GCK) gene.
Tongtong Dai, Yun Yang, Juanjuan Zhang, Xiaoyu Ma, Lifen Chen, Caiping Zhang, Sheng Lv, Lin Li, Renqiao Tang, Ni Zhen, Wenli Lu, Chuanyin Li, Ronggui Hu, Yuan Xiao, Zhiya Dong   +14 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Characterization of a novel glucokinase activator in rat and mouse models. [PDF]

PLoS ONE, 2014
Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate. Glucokinase activators are being investigated as potential diabetes therapies because of their effects on hepatic glucose output and/or insulin
Min Lu, Pingping Li, Gautam Bandyopadhyay, William Lagakos, Walter E Dewolf, Taylor Alford, Mark Joseph Chicarelli, Lance Williams, Deborah A Anderson, Brian R Baer, Maralee McVean, Marion Conn, Murielle M Véniant, Peter Coward   +13 more
doaj   +1 more source

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states

Molecular Metabolism, 2021
Objective: While the molecular events controlling insulin secretion from β-cells have been documented in detail, the exact mechanisms governing glucagon release by α-cells are understood only partially.
Varun Bahl, Catherine Lee May, Alanis Perez, Benjamin Glaser, Klaus H. Kaestner   +4 more
doaj   +1 more source

Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex

Translational Neuroscience, 2022
Brain metabolic-sensory targets for modulatory glucose-sensitive endocrine and neurochemical signals remain unidentified. A hypothalamic astrocyte primary culture model was here used to investigate whether glucocorticoid receptor (GR) and noradrenergic ...
Alhamyani Abdulrahman, Napit Prabhat R., Bheemanapally Khaggeswar, Sylvester Paul W., Briski Karen P.   +4 more
doaj   +1 more source