Chronic glucocorticoid-rich milieu and liver dysfunction [PDF]
, 2016 We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats.
Castro, María Cecilia +7 more
core +6 more sources
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]
, 2017 Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José +10 more
core +1 more source
ADP-dependent Phosphofructokinases in Mesophilic and Thermophilic Methanogenic Archaea [PDF]
, 2001 Phosphofructokinase (PFK) is a key enzyme of the glycolytic pathway in all domains of life. Two related PFKs, ATP-dependent and PPi-dependent PFK, have been distinguished in bacteria and eucarya, as well as in some archaea.
Verhees, C.H. +5 more
core +1 more source
The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae [PDF]
, 2019 HAMLET is a complex of human a-lactalbumin (ALA) and oleic acid and kills several Gram-positive bacteria by a mechanism that bears resemblance to apoptosis in eukaryotic cells. To identify HAMLET's bacterial targets, here we used Streptococcus pneumoniae
Hakansson, Anders P. +3 more
core +2 more sources
Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice.
PLoS ONE, 2013 Aims/hypothesisGlucose sensing (eg. glucokinase activity) becomes impaired in the development of type 2 diabetes, the etiology of which is unclear. Estrogen can stimulate glucokinase activity, whereas the pervasive environmental pollutant bisphenol A ...
Leigh Perreault +5 more
doaj +1 more source
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
PLoS Pathogens, 2013 Mycobacterium tuberculosis (Mtb) is thought to preferentially rely on fatty acid metabolism to both establish and maintain chronic infections. Its metabolic network, however, allows efficient co-catabolism of multiple carbon substrates.
Joeli Marrero +3 more
doaj +1 more source
Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways [PDF]
, 2019 Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow, especially at low salinity ...
Argandoña Bertrán, Montserrat +12 more
core +1 more source
Genetic Dissection of a QTL Affecting Bone Geometry. [PDF]
, 2017 Parameters of bone geometry such as width, length, and cross-sectional area are major determinants of bone strength. Although these traits are highly heritable, few genes influencing bone geometry have been identified.
Farber, Charles R +2 more
core +2 more sources
Frontiers in Neuroscience, 2019 Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins ...
Magdiel Salgado +5 more
doaj +1 more source
Sugar Phosphorylation Controls Carbon Source Utilization and Virulence of Candida albicans
Frontiers in Microbiology, 2020 Candida albicans is an opportunistic human fungal pathogen that relies upon different virulence traits, including morphogenesis, invasion, biofilm formation, and nutrient acquisition from host sources as well as metabolic adaptations during host invasion.
Stefanie Wijnants +6 more
doaj +1 more source