Results 21 to 30 of about 17,223 (183)

Sugar Phosphorylation Controls Carbon Source Utilization and Virulence of Candida albicans

Frontiers in Microbiology, 2020
Candida albicans is an opportunistic human fungal pathogen that relies upon different virulence traits, including morphogenesis, invasion, biofilm formation, and nutrient acquisition from host sources as well as metabolic adaptations during host invasion.
Stefanie Wijnants, Stefanie Wijnants, Michael Riedelberger, Philipp Penninger, Karl Kuchler, Patrick Van Dijck, Patrick Van Dijck   +6 more
doaj   +1 more source

Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight

Molecules, 2023
Glucokinase plays an important role in regulating the blood glucose level and serves as an essential therapeutic target in type 2 diabetes management. Entada africana is a medicinal plant and highly rich source of bioactive ligands with the potency to ...
Sunday Amos Onikanni, Bashir Lawal, Valens Munyembaraga, Oluwafemi Shittu Bakare, Muhammad Taher, Junaidi Khotib, Deny Susanti, Babatunji Emmanuel Oyinloye, Lloyd Noriega, Ayodeji Famuti, Adewale Oluwaseun Fadaka, Basiru Olaitan Ajiboye   +11 more
doaj   +1 more source

Specific insulin and proinsulin secretion in glucokinase-deficient individuals

Brazilian Journal of Medical and Biological Research, 1999
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (MODY).
V.C. Pardini, G. Velho, R. Reis, S. Purisch, H. Blanché, J.G.H. Vieira, R.C.S. Moisés   +6 more
doaj   +1 more source

Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene

Сахарный диабет, 2018
Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy.
Natalia A. Zubkova, Fatima F. Burumkulova, Victoria I. Ulyatovskaya, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Tatiana S. Budykina, Nina A. Makretskaya, Anatoly N. Tiulpakov   +8 more
doaj   +1 more source

An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism [PDF]

Journal of Biological Chemistry, 2006
Glucokinase (GK) plays a key role in the control of blood glucose homeostasis. We identified a small molecule GK activator, compound A, that increased the glucose affinity and maximal velocity (V(max)) of GK. Compound A augmented insulin secretion from isolated rat islets and enhanced glucose utilization in primary cultured rat hepatocytes. In rat oral
Mayumi, Futamura, Hideka, Hosaka, Akito, Kadotani, Hiroko, Shimazaki, Kaori, Sasaki, Sumika, Ohyama, Teruyuki, Nishimura, Jun-Ichi, Eiki, Yasufumi, Nagata   +8 more
openaire   +2 more sources

EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS

Berkala Kedokteran, 2017
: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats.
Iskandar Thalib, Windy Yuliana Budianto, Eko Suhartono   +2 more
doaj   +1 more source

Glucokinase: evolution, regulatory properties, role in the pathogenesis of type 2 diabetes mellitus

Acta Biomedica Scientifica
The review examines the evolution, structural and functional organization and regulatory properties of glucokinase, which is predominantly expressed in β-cells of the pancreas and in liver hepatocytes.
L. A. Kuznetsova, N. E. Basova, A. O. Shpakov   +2 more
doaj   +1 more source

Clinical, Laboratory and Genetic Characteristics of Children with GCK-MODY (MODY2): Report of Four Novel Variants in GCK Gene

Trends in Pediatrics, 2020
Objective: Maturity-Onset Diabetes of the Young (MODY) is the most common type of monogenic diabetes. Heterozygous inactivating variants in glucokinase (GCK) gene are related to MODY2 (GCK–MODY).
Mustafa Altan, Ayşe Anık, Nilay Tuğçe Işık Bayar, Gokay Bozkurt, Tolga Ünüvar, Ahmet Anık   +5 more
doaj   +1 more source

The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Metabolites, 2021
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber, Nicholas B. Whitticar, Daniel R. Rochester, Kathryn L. Corbin, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source

GENETICS OF YEAST GLUCOKINASE [PDF]

Genetics, 1983
ABSTRACT Mutants of Saccharomyces cerevisiae lacking glucokinase (EC 2.7.1.2) have no discernible phenotypic difference from the wild-type strain; in a hexokinaseless background, however, they are unable to grow on any sugar except galactose. Reversion studies with glucokinase mutants indicate that the yeast S.
P K, Maitra, Z, Lobo
openaire   +2 more sources