Results 21 to 30 of about 21,204 (221)

From glucose sensing to exocytosis: takes from maturity onset diabetes of the young

Frontiers in Endocrinology, 2023
Monogenic diabetes gave us simplified models of complex molecular processes occurring within β-cells, which allowed to explore the roles of numerous proteins from single protein perspective.
Sama Samadli, Sama Samadli, Qiaoli Zhou, Bixia Zheng, Wei Gu, Aihua Zhang   +5 more
doaj   +1 more source

Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice.

PLoS ONE, 2013
Aims/hypothesisGlucose sensing (eg. glucokinase activity) becomes impaired in the development of type 2 diabetes, the etiology of which is unclear. Estrogen can stimulate glucokinase activity, whereas the pervasive environmental pollutant bisphenol A ...
Leigh Perreault, Carrie McCurdy, Anna A Kerege, Julie Houck, Kristine Færch, Bryan C Bergman   +5 more
doaj   +1 more source

Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.

PLoS Pathogens, 2013
Mycobacterium tuberculosis (Mtb) is thought to preferentially rely on fatty acid metabolism to both establish and maintain chronic infections. Its metabolic network, however, allows efficient co-catabolism of multiple carbon substrates.
Joeli Marrero, Carolina Trujillo, Kyu Y Rhee, Sabine Ehrt   +3 more
doaj   +1 more source

When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes

Frontiers in Neuroscience, 2019
Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins ...
Magdiel Salgado, Patricio Ordenes, Marcos Villagra, Elena Uribe, María de los Angeles García-Robles, Estefanía Tarifeño-Saldivia   +5 more
doaj   +1 more source

Sugar Phosphorylation Controls Carbon Source Utilization and Virulence of Candida albicans

Frontiers in Microbiology, 2020
Candida albicans is an opportunistic human fungal pathogen that relies upon different virulence traits, including morphogenesis, invasion, biofilm formation, and nutrient acquisition from host sources as well as metabolic adaptations during host invasion.
Stefanie Wijnants, Stefanie Wijnants, Michael Riedelberger, Philipp Penninger, Karl Kuchler, Patrick Van Dijck, Patrick Van Dijck   +6 more
doaj   +1 more source

Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight

Molecules, 2023
Glucokinase plays an important role in regulating the blood glucose level and serves as an essential therapeutic target in type 2 diabetes management. Entada africana is a medicinal plant and highly rich source of bioactive ligands with the potency to ...
Sunday Amos Onikanni, Bashir Lawal, Valens Munyembaraga, Oluwafemi Shittu Bakare, Muhammad Taher, Junaidi Khotib, Deny Susanti, Babatunji Emmanuel Oyinloye, Lloyd Noriega, Ayodeji Famuti, Adewale Oluwaseun Fadaka, Basiru Olaitan Ajiboye   +11 more
doaj   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

Specific insulin and proinsulin secretion in glucokinase-deficient individuals

Brazilian Journal of Medical and Biological Research, 1999
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (MODY).
V.C. Pardini, G. Velho, R. Reis, S. Purisch, H. Blanché, J.G.H. Vieira, R.C.S. Moisés   +6 more
doaj   +1 more source

An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism [PDF]

Journal of Biological Chemistry, 2006
Glucokinase (GK) plays a key role in the control of blood glucose homeostasis. We identified a small molecule GK activator, compound A, that increased the glucose affinity and maximal velocity (V(max)) of GK. Compound A augmented insulin secretion from isolated rat islets and enhanced glucose utilization in primary cultured rat hepatocytes. In rat oral
Mayumi, Futamura, Hideka, Hosaka, Akito, Kadotani, Hiroko, Shimazaki, Kaori, Sasaki, Sumika, Ohyama, Teruyuki, Nishimura, Jun-Ichi, Eiki, Yasufumi, Nagata   +8 more
openaire   +2 more sources

Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene

Сахарный диабет, 2018
Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy.
Natalia A. Zubkova, Fatima F. Burumkulova, Victoria I. Ulyatovskaya, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Tatiana S. Budykina, Nina A. Makretskaya, Anatoly N. Tiulpakov   +8 more
doaj   +1 more source