Results 41 to 50 of about 31,450 (226)
Trends in Pediatrics, 2020 Objective: Maturity-Onset Diabetes of the Young (MODY) is the most common type of monogenic diabetes. Heterozygous inactivating variants in glucokinase (GCK) gene are related to MODY2 (GCK–MODY).
Mustafa Altan +5 more
doaj +1 more source
Metabolites, 2021 Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber +5 more
doaj +1 more source
, 2005 A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level.
Airley R +26 more
core +1 more source
Brain glucose sensing, glucokinase and neural control of metabolism and islet function. [PDF]
, 2014 It is increasingly apparent that the brain plays a central role in metabolic homeostasis, including the maintenance of blood glucose. This is achieved by various efferent pathways from the brain to periphery, which help control hepatic glucose flux and ...
Biggers DW +6 more
core +2 more sources
Diagnostic Difficulties in Glucokinase Hyperinsulinism [PDF]
Hormone and Metabolic Research, 2008 Glucokinase hyperinsulinism is a rare variant of congenital hyperinsulinism caused by activating mutations in the glucokinase gene and has been reported so far to be a result of overactivity of glucokinase within the pancreatic beta-cell. Here we report on a new patient with difficulties to diagnose persistent hyperinsulinism and discuss diagnostic ...
Meissner, T. +13 more
openaire +3 more sources
Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD) [PDF]
, 2018 Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease ...
Campo, José Antonio del +3 more
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Novel glucokinase mutation in a boy with maturity-onset diabetes of the young [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Maturity-onset diabetes of the young (MODY) is a heterogenous group of disorders characterized by an early onset of insulin-independent diabetes mellitus, an autosomal dominant mode of inheritance and a primary defect in beta-cell. There are
Milenković Tatjana +2 more
doaj +1 more source
Functional characterization of hexokinases in the moss Physcomitrella patens [PDF]
, 2005 Carbohydrates are important nutrients and structural components in all living organisms. In plants they affect the developmental and metabolic processes throughout the plant life cycle.
Olsson, Tina
core
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
Nature Communications, 2018 During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory ...
Hitoshi Watanabe +6 more
doaj +1 more source
Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]
, 2014 BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B +7 more
core +3 more sources