Results 41 to 50 of about 21,204 (221)
Novel glucokinase mutation in a boy with maturity-onset diabetes of the young [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Maturity-onset diabetes of the young (MODY) is a heterogenous group of disorders characterized by an early onset of insulin-independent diabetes mellitus, an autosomal dominant mode of inheritance and a primary defect in beta-cell. There are
Milenković Tatjana +2 more
doaj +1 more source
Vaginal host–microbe signatures linked to placental outcomes in mares
Equine Veterinary Journal, EarlyView.Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule +7 more
wiley +1 more source
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
Nature Communications, 2018 During diabetes, postprandial hyperglycemia is caused by impaired glucose uptake. Here, Watanabe and colleagues show that impaired hepatic glucose uptake during obesity is caused by a reduction in Sirt2 activity, which promotes glucokinase regulatory ...
Hitoshi Watanabe +6 more
doaj +1 more source
Food Bioengineering, EarlyView.Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu +6 more
wiley +1 more source
, 2013 Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver ...
Blázquez Fernández, Enrique +7 more
core +1 more source
Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization [PDF]
Biochemical Journal, 2000 Conditional expression of the glucokinase regulatory protein in insulinoma cells, under control of the reverse tetracycline-dependent transactivator, was used to investigate whether expression of this protein de novo would alter the intracellular distribution of glucokinase.
BOSCO, Domenico +2 more
openaire +3 more sources
Induced biosynthesis of liver glucokinase
, 1964 A glucokinase qualitatively and quantitatively adequate as the first and limiting step in the synthesis of glycogen from glucose in liver has recently been identified in normal fed rats. In contrast with hexokinase, that also occurs in liver, glucokinase
Sols, Alberto +2 more
core +1 more source
Frontiers in Physiology, 2019 It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine
Franz M. Matschinsky, David F. Wilson
doaj +1 more source
Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase
, 2018 Glucokinase (GCK) plays a key role in glucose homeostasis. Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2.
Olivier Vincent +9 more
core +1 more source
Adaptive character of liver glucokinase [PDF]
, 1975 1. Glucokinase is one of four glucose phos-phorylating enzymes present in rat liver. Its distinctive features are a high Km for glucose (high-Km isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called
Ureta, Tito +2 more
core +1 more source