Results 51 to 60 of about 17,223 (183)

Genotype‐Dependent Functional and Pharmacological Profiling of Rare GCK Variants Reveals Implications for Precision Management of Monogenic Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Rare GCK variants contribute to heterogeneous forms of monogenic diabetes, yet the molecular basis underlying their diverse functional consequences and pharmacological responsiveness remains incompletely understood. As glucokinase (GCK) serves as a central glucose sensor in pancreatic β‐cells and hepatocytes, defining the functional ...
Haoyu Bai, Jie Yu, Qiusha Zhu, Xue Zhou, Ting Xie, Tong Wang, Jing Ren, Chuhan Shao, Qian Zhang, Changhong Li, Xinhua Xiao   +10 more
wiley   +1 more source

Enhancing fetal outcomes in GCK-MODY pregnancies: a precision medicine approach via non-invasive prenatal GCK mutation detection

Frontiers in Medicine
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Valérie M. Schwitzgebel, Valérie M. Schwitzgebel, Jean-Louis Blouin, Jean-Louis Blouin, Barbara Dehos, Bettina Köhler-Ballan, Jardena J. Puder, Claudine Rieubland, Maria Triantafyllidou, Anne Zanchi, Marc Abramowicz, Marc Abramowicz, Thierry Nouspikel, Thierry Nouspikel   +13 more
doaj   +1 more source

Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction

Future Journal of Pharmaceutical Sciences, 2019
Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA).
Saurabh C. Khadse, Nikhil D. Amnerkar, Manasi U. Dave, Deepak K. Lokwani, Ravindra R. Patil, Vinod G. Ugale, Nitin B. Charbe, Vivekanand A. Chatpalliwar   +7 more
doaj   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

Scientific Reports, 2017
Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood.
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Mayu Kyohara, Shunsuke Yamazaki, Kazuki Tajima, Yu Togashi, Yasuo Terauchi   +7 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans

Frontiers in Microbiology, 2019
The pathogenic yeast Candida albicans is both a powerful commensal and a pathogen of humans that can infect wide range of organs and body sites. Metabolic flexibility promotes infection and commensal colonization by this opportunistic pathogen.
Romain Laurian, Karine Dementhon, Bastien Doumèche, Alexandre Soulard, Thierry Noel, Marc Lemaire, Pascale Cotton   +6 more
doaj   +1 more source

Hidden Strategies Beneath a Single Nucleotide: Contrasting Physiology in Lichen Photobiont Strains

Plant, Cell &Environment, EarlyView.
ABSTRACT Lichen photobionts exhibit significant physiological variability with important ecological implications. While this variability is relatively well studied at the interspecific level, it has rarely been examined at the intraspecific level. Here, we investigated the physiological responses to temperature and irradiance of two Trebouxia lynniae ...
Miguel Blázquez, David Pizarro, Ana García‐Muñoz, Raquel Pino‐Bodas, Asunción de los Ríos, Miren I. Arzac, José Ignacio García‐Plazaola, Beatriz Fernández‐Marín, Unai Artetxe, Rosa Toledo‐Gil, Fernando Vallejo, Leonardo M. Casano, Israel Pérez‐Vargas, Sergio Pérez‐Ortega, Francisco Gasulla   +14 more
wiley   +1 more source

Substrate specificity of glucokinase and fructokinase of several conifer species

Acta Societatis Botanicorum Poloniae, 2014
Annual plant species were found to have several distinct classes of hexokinases which are specific for different hexoses, such as glucose, fructose and mannose.
Fritz Bergmanni, Leon Mejnartowicz
doaj   +1 more source