Results 51 to 60 of about 21,204 (221)

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein [PDF]

Biochemistry, 2013
Glucokinase (GCK) is responsible for maintaining glucose homeostasis in the human body. Dysfunction or misregulation of GCK causes hyperinsulinemia, hypertriglyceridemia, and type 2 diabetes. In the liver, GCK is regulated by interaction with the glucokinase regulatory protein (GKRP), a 68 kDa polypeptide that functions as a competitive inhibitor of ...
Tobias Beck, Brian G. Miller
openaire   +4 more sources

ANALYSIS OF MICRORNA EXPRESSION PATTERN IN SMALL INTESTINE OF CELIAC PATIENTS [PDF]

, 2010
Celiac disease (CD) is a chronic inflammatory disease characterized by small intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals following the dietary ingestion of gluten1.
Capuano, Marina
core   +1 more source

Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations

eLife
Oscillations in insulin secretion, driven by islet Ca2+ waves, are crucial for glycemic control. Prior studies, performed with single-plane imaging, suggest that subpopulations of electrically coupled β-cells have privileged roles in leading and ...
Erli Jin, Jennifer K Briggs, Richard KP Benninger, Matthew J Merrins   +3 more
doaj   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Advantages of low‐glycaemic‐index carbohydrates in regulating glycaemic response of energy bar: A review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Energy bars are widely consumed functional foods among athletes and physically active consumers who require convenient sources of sustained energy. Their carbohydrate composition, particularly the type and ratio of digestible sugars such as glucose, fructose and sucrose, strongly influences glycaemic index (GI), postprandial blood glucose ...
Raju Sasikumar, Ayush Gupta, Selva Kumar T, Kaviarasu Ganesan, Sheena Haorongbam, Ravikumar Rajarathinam, Sandeep Janghu, Sandeep Kumar Panda, Amit K. Jaiswal   +8 more
wiley   +1 more source

On the glucokinase activity of extracts from normal and atrophic muscles [PDF]

, 1952
The glucokinase activity of extracts of muscles of various species (man, rabbit, guinea-pig, rat and chicken) has been determined. The activity of an extract prepared from a rabbit muscle, which had atrophied in the course of three to four weeks as a
Gerritsen, T.
core   +1 more source

Diagnostic Difficulties in Glucokinase Hyperinsulinism [PDF]

Hormone and Metabolic Research, 2008
Glucokinase hyperinsulinism is a rare variant of congenital hyperinsulinism caused by activating mutations in the glucokinase gene and has been reported so far to be a result of overactivity of glucokinase within the pancreatic beta-cell. Here we report on a new patient with difficulties to diagnose persistent hyperinsulinism and discuss diagnostic ...
Meissner, T., Marquard, J., Cobo-Vuilleumier, Nadia, Maringa, M., Rodríguez-Bada, P., García-Gimeno, María Adelaida, Castro, M. J., Aledo, J. C., Baixeras, Elena, Weber, J., Olek, K., Sanz, Pascual, Mayatepek, E., Cuesta-Muñoz, Antonio L.   +13 more
openaire   +3 more sources

Hormonal and Metabolite Regulation of Hepatic Glucokinase

Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity is dependent on reversible binding of glucokinase to a specific ...
Agius L
core   +4 more sources

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator.

PLoS ONE, 2022
Glucokinase activators are regarded as potent candidates for diabetes treatment, however, in clinical studies on patients with type 2 diabetes, a diminishing efficacy was observed after chronic treatment with them. The mechanism of this reduction has not
Yoshinori Tsumura, Yu Tsushima, Azusa Tamura, Hirotsugu Kato, Tsunefumi Kobayashi   +4 more
doaj   +1 more source