Results 71 to 80 of about 31,450 (226)

Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex

Journal of Sleep Research, EarlyView.
ABSTRACT Obstructive sleep apnea (OSA), marked by intermittent hypoxia, is associated with obesity, type 2 diabetes and metabolic associated fatty liver disease. In pregnancy, it remains underdiagnosed despite links to gestational diabetes, hypertension, and foetal growth restriction.
Esther Valverde‐Perez, Margarida B. Almeida, Joana F. Sacramento, Elena Olea, Jesus Prieto‐Lloret, Asuncion Rocher, Silvia V. Conde   +6 more
wiley   +1 more source

Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. [PDF]

, 2012
Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Butte, AJ, Chen, R, Corona, E, Kang, HP, Schadt, EE, Yang, X, Zhang, B   +6 more
core   +2 more sources

Crystal structures of Escherichia coli glucokinase acetylation‐mimicking variants and insights into the impact of acetylation

Acta Crystallographica Section F, Volume 82, Issue 5, Page 160-166, May 2026.
This work reports the crystal structures of K214Q and K216Q variants of E. coli glucokinase, demonstrating a potential role of lysine acetylation in regulating glucokinase activity.In this study, we report the crystal structures of K214Q and K216Q variants of Escherichia coli glucokinase (ecGLK), each of which is bound to phosphate in the active‐site ...
Joseph Andrews, Joshua Sakon, Chenguang Fan   +2 more
wiley   +1 more source

Expression of the human glucokinase gene: important roles of the 5' flanking and intron 1 sequences. [PDF]

PLoS ONE, 2012
Glucokinase plays important tissue-specific roles in human physiology, where it acts as a sensor of blood glucose levels in the pancreas, and a few other cells of the gut and brain, and as the rate-limiting step in glucose metabolism in the liver.
Yi Wang, Tingting Guo, Shuyong Zhao, Zhixin Li, Yiqing Mao, Hui Li, Xi Wang, Rong Wang, Wei Xu, Rongjing Song, Ling Jin, Xiuli Li, David M Irwin, Gang Niu, Huanran Tan   +14 more
doaj   +1 more source

Cloning and characterization of feline islet glucokinase [PDF]

, 2014
Background: Glucokinase (GK) is a metabolic enzyme encoded by the GCK gene and expressed in glucose-sensitive tissues, principally pancreatic islets cell and hepatocytes.
LeCluyse, Michelle, Lindbloom-Hawley, Sara, Lushington, Gerald Henry, Schermerhorn, Thomas, Vandersande, Vanessa   +4 more
core   +3 more sources

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

The gene YALI0E20207g from Yarrowia lipolytica encodes an N-acetylglucosamine kinase implicated in the regulated expression of the genes from the N-acetylglucosamine assimilatory pathway [PDF]

, 1944
This is an open access article distributed under the terms of the Creative Commons Attribution License.The non-conventional yeast Yarrowia lipolyticapossesses an ORF, YALI0E20207g, which encodes a protein with an amino acid sequence similar to ...
Flores, Carmen-Lisset, Gancedo, Carlos
core   +3 more sources

An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism [PDF]

Journal of Biological Chemistry, 2006
Glucokinase (GK) plays a key role in the control of blood glucose homeostasis. We identified a small molecule GK activator, compound A, that increased the glucose affinity and maximal velocity (V(max)) of GK. Compound A augmented insulin secretion from isolated rat islets and enhanced glucose utilization in primary cultured rat hepatocytes. In rat oral
Mayumi, Futamura, Hideka, Hosaka, Akito, Kadotani, Hiroko, Shimazaki, Kaori, Sasaki, Sumika, Ohyama, Teruyuki, Nishimura, Jun-Ichi, Eiki, Yasufumi, Nagata   +8 more
openaire   +2 more sources

Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider

Molecular Ecology Resources, Volume 26, Issue 4, May 2026.
ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li, Yunyun Lv, Chao Bian, Quentin Moana Perrin, Yubo Zhang, Yixiao Wang, Lei Cao, Long Yu, Shengtao Guo, Wei Zhang, Qiong Shi, Daiqin Li   +11 more
wiley   +1 more source

Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding [PDF]

, 2014
In dogs consuming a high-fat and -fructose diet (52 and 17% of total energy, respectively) for 4 wk, hepatic glucose uptake (HGU) in response to hyperinsulinemia, hyperglycemia, and portal glucose delivery is markedly blunted with reduction in ...
Cherrington, Alan D., Coate, Katie C., Farmer, Ben, Irimia, Jose M., Kraft, Guillaume, Moore, Mary Courtney, Neal, Doss W., Ramnanan, Christopher, Roach, Peter J., Smith, Marta S., Williams, Phil   +10 more
core   +1 more source