Results 71 to 80 of about 17,223 (183)

Case Report: New insights about clinical manifestations of patients with GCK genetic variants

Frontiers in Endocrinology
GCK-MODY is a genetic condition characterized by alterations in the GCK gene, which can include several types of inactivating genetic variants - ranging from missense and nonsense variants, and splice site variants, to small and large deletions and ...
Ritiele Bastos de Souza, Gabriella de Medeiros Abreu, Gabriella de Medeiros Abreu, Marília Chaves Bernardo, Roberta Magalhães Tarantino, Melanie Rodacki, Lenita Zajdenverg, Amanda Ferreira de Andrade, Deborah Snaider Nicolay, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Renata Szundy Berardo, Jorge Luiz Luescher, Verônica Marques Zembrzuski, Pedro Hernan Cabello, Mario Campos Junior   +19 more
doaj   +1 more source

Effect of Cyclocarya paliurus on Glucose Metabolism and Intestinal GLP-1 Secretion in Type 2 Diabetic Rats

Shipin gongye ke-ji
Objective: This study aimed to evaluate the hypoglycemic effect of Cyclocarya paliurus on type 2 diabetic rats and its impact on glucagon-like peptide-1 (GLP-1) secretion, and to preliminarily explore its mechanism.
Yaqian ZOU, Liang CHEN, Jia MU, Yajing WANG, Xumeng CHEN   +4 more
doaj   +1 more source

Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)

Сахарный диабет, 2019
An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019)
Natalia A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasilyev, Vasily M. Petrov, Anatoly N. Tiulpakov   +7 more
doaj   +1 more source

Integrative clinicogenomic analysis of the monoallelic pathogenic substitution p.Thr228Met in the GCK gene as a nosological marker of type 3 diabetes (MODY 2) with a phenotype of moderate stable hyperglycemia and preserved β-cell secretory capacity

Клинический разбор в общей медицине
Monogenic forms of diabetes mellitus, collectively classified as MODY (Maturity Onset Diabetes of the Young), represent rare, genetically determined variants of the disease with an autosomal dominant inheritance pattern, typically manifesting at a young ...
Svyatoslav M. Yurin, Dmitry A. Apalkov, Tatiana A. Minenkova, Natalia S. Razinkova, Alexandra V. Serezhkina   +4 more
doaj   +1 more source

TAT-PBX1 Reverses Hyperglycemia Through β-Cell Regeneration and Functional Restoration in an STZ-Induced Diabetic Model

Pharmaceuticals
Objective: β-cell dysfunction and loss are major pathological determinants of impaired islet function and hyperglycemia in diabetes. Given the inability of current therapies to restore β-cell viability or glucose-responsive insulin secretion, this study ...
Xiangyuan Meng, Zhenhu Zhao, Xin Zhang, Ruihan Guo, Shuran Yang, Shuhua Mao, Ziyu Zong, Jinyu Liu   +7 more
doaj   +1 more source

Course of pregnancy and 10-year observation of twins diagnosed with GCK-MODY in the neonatal period: a case report

Frontiers in Endocrinology
Monogenic diabetes accounts for 5% of all incidence of hyperglycemia and Maturity Onset Diabetes of the Young (MODY) is the most common form. In GCK-MODY, one of the most common forms of MODY, hyperglycemia is caused by a mutation of a gene responsible ...
Barbara Katra, Barbara Katra, Magdalena Szopa, Magdalena Szopa   +3 more
doaj   +1 more source

Glucokinase and the potential of glucokinase activation in type 2 diabetes [PDF]

Journal of Diabetes, 2019
openaire   +2 more sources

Nomenclature for mammalian glucokinase [PDF]

Biochemical Journal, 1991
P B, Iynedjian, J, Girard
openaire   +2 more sources

Resetting the glucose sensor: dorzagliatin and the evolution of glucokinase activation in diabetes therapy. [PDF]

BMJ Open Diabetes Res Care
Chang M, Shen P, Shen G.
europepmc   +1 more source

Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea-Nauclea latifolia-Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease. [PDF]

ChemistryOpen
Tientcheu JPD, İstifli ES.
europepmc   +1 more source