Results 71 to 80 of about 21,204 (221)

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Enhancing fetal outcomes in GCK-MODY pregnancies: a precision medicine approach via non-invasive prenatal GCK mutation detection

Frontiers in Medicine
BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Valérie M. Schwitzgebel, Valérie M. Schwitzgebel, Jean-Louis Blouin, Jean-Louis Blouin, Barbara Dehos, Bettina Köhler-Ballan, Jardena J. Puder, Claudine Rieubland, Maria Triantafyllidou, Anne Zanchi, Marc Abramowicz, Marc Abramowicz, Thierry Nouspikel, Thierry Nouspikel   +13 more
doaj   +1 more source

Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction

Future Journal of Pharmaceutical Sciences, 2019
Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA).
Saurabh C. Khadse, Nikhil D. Amnerkar, Manasi U. Dave, Deepak K. Lokwani, Ravindra R. Patil, Vinod G. Ugale, Nitin B. Charbe, Vivekanand A. Chatpalliwar   +7 more
doaj   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Fungicidal Efficacy of Leaf Extracts From Khaya senegalensis (Desr.) A. Juss. Irrigated With Agricultural Drainage Water and Treated With Some Fertilizer Types

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The extraction and analysis of K. senegalensis compounds for wood preservation. Air‐dried leaves are milled, soaked in ethanol, filtered, and concentrated into dried extracts. These extracts undergo HPLC for chemical profiling. The concentrated extract is applied to wood samples to test its antifungal activity, demonstrating its potential as a natural ...
Esraa A. M. Mohamed, Ahmed M. El‐Baha, Ahmed A. A. El‑Settawy, Nader D. Shetta, Abeer A. Mohamed, Mohamed Z. M. Salem   +5 more
wiley   +1 more source

Genetic control of glucokinase activity in mice.

, 1977
Inbred strains of mice were surveyed for liver glucokinase activity. Mice of all strains studied could be distributed into three groups with high, intermediate, and low levels of enzyme activity.
Coleman, D L
core   +1 more source

Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

Scientific Reports, 2017
Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood.
Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Mayu Kyohara, Shunsuke Yamazaki, Kazuki Tajima, Yu Togashi, Yasuo Terauchi   +7 more
doaj   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

Glucokinase is located in secretory granules of pancreatic D-cells [PDF]

, 1997
We immunohistochemically examined the distribution of glucokinase in rat pancreatic islets. Glucokinase immunoreactivity under light microscopy was detected in the cytoplasm of somatostatin cells as well as in that of insulin cells.
Ito, Yuki, Yuki Ito, Yoshie, Sumio, Miwa, Ichitomo, Toyoda, Yukiyasu, Nonogaki, Tsunemasa, Fujita, Tsuneo, Yukiyasu Toyoda, Sumio Yoshie, Tsuneo Fujita, Ichitomo Miwa, Tsunemasa Nonogaki   +11 more
core   +1 more source

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans

Frontiers in Microbiology, 2019
The pathogenic yeast Candida albicans is both a powerful commensal and a pathogen of humans that can infect wide range of organs and body sites. Metabolic flexibility promotes infection and commensal colonization by this opportunistic pathogen.
Romain Laurian, Karine Dementhon, Bastien Doumèche, Alexandre Soulard, Thierry Noel, Marc Lemaire, Pascale Cotton   +6 more
doaj   +1 more source