Results 81 to 90 of about 31,450 (226)
Diabetic Medicine, Volume 43, Issue 5, May 2026.Abstract Aims Maturity‐Onset Diabetes of the Young (MODY) results from a single‐gene defect. This study aimed to determine the minimal prevalence, screening indicators, as well as clinical characteristics of MODY in the Czech Republic based on data from 25 years of the nationwide registry.
Petra Dusatkova +8 more
wiley +1 more source
Frontiers in MedicineBackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype.
Valérie M. Schwitzgebel +13 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2019 Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA).
Saurabh C. Khadse +7 more
doaj +1 more source
Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
core +2 more sources
ChREBP‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Schematic diagram of the mechanism underlying fructose‐induced renal tubular injury via ChREBP‐β‐mediated disruption of endoplasmic reticulum and mitochondrial homeostasis. This diagram illustrates that fructose induces the transcriptional activation of ChREBP‐β, which subsequently triggers endoplasmic reticulum stress, disturbs inter‐organelle calcium
Ting Fang +7 more
wiley +1 more source
Molecular Physiology of Mammalian Glucokinase [PDF]
Cellular and Molecular Life Sciences, 2008 The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human "diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK.
openaire +4 more sources
DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid [PDF]
, 2016 Additional file 3: Figure S2. Liver and epididymal fat weights in db/+ mice and db/db mice. The experiments were performed in db/+ or db/db mice fed an SL diet, SO diet, SL containing DPP-4 inhibitor (0.4% des-fluoro-sitagliptin) diet, or SO containing ...
Eiko Yoshida +10 more
core +5 more sources
Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Frontiers in Microbiology, 2019 The pathogenic yeast Candida albicans is both a powerful commensal and a pathogen of humans that can infect wide range of organs and body sites. Metabolic flexibility promotes infection and commensal colonization by this opportunistic pathogen.
Romain Laurian +6 more
doaj +1 more source
Cross-sectional and longitudinal studies suggest pharmacological treatment used in patients with glucokinase mutations does not alter glycaemia [PDF]
, 2013 This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Heterozygous glucokinase (GCK) mutations cause mild, fasting hyperglycaemia from birth. Although patients are usually
Chakera, AJ +6 more
core +1 more source