Results 81 to 90 of about 21,204 (221)

Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus

Genetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Complex disorders such as depression and alcohol use involve numerous genetic variants, and implicated loci continue to grow with sample size. This proliferation hampers interpretability, as the mechanisms by which so many variants jointly contribute to pathophysiology remain unclear.
Eric V. Strobl
wiley   +1 more source

New perspectives on pancreatic islet glucokinase

, 1984
Control of blood sugar involves the complex interaction of the pancreatic glucose-sensing beta-cells with the liver, which serves as the primary site of glucose disposal after a meal.
F. M. Matschinsky, M. D. Meglasson
core   +1 more source

Substrate specificity of glucokinase and fructokinase of several conifer species

Acta Societatis Botanicorum Poloniae, 2014
Annual plant species were found to have several distinct classes of hexokinases which are specific for different hexoses, such as glucose, fructose and mannose.
Fritz Bergmanni, Leon Mejnartowicz
doaj   +1 more source

The Branching Projection Pattern of Ventral Subicular Cells Revealing the Complex Integrative Role of Key Hippocampal Outputs in Driving Fear and Anxiety

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT The ventral regions of the hippocampus play a crucial role in emotional responses through projections to the hypothalamus. In this context, the ventral hippocampus sends extensive projections to components of the medial hypothalamic defensive circuit, where projections to the anterior hypothalamic nucleus (AHN) influence both anxiogenic and ...
Fernando Falkenburger Melleu, Karolina Domingues, Isadora D'Ávila Tassinari, Newton Sabino Canteras   +3 more
wiley   +1 more source

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the livers⃞

Journal of Lipid Research, 2007
Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate the role of glucose metabolism on hepatic gene expression independently from insulin action, we ...
Núria Morral, Howard J. Edenberg, Scott R. Witting, Jennifer Altomonte, Tearina Chu, Matthew Brown   +5 more
doaj   +1 more source

Short-term regulation of glucokinase

, 1994
The activity of liver glucokinase is controlled in the short term by the concentration of its substrate glucose and by a regulatory protein, which acts as a competitive inhibitor with respect to glucose.
Van Schaftingen, Emile
core   +1 more source

Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment

Frontiers in Physiology
The circadian clock, an innate timing mechanism, governs a variety of physiological activities by producing near-24-h cycles in gene expression. These cycles are reflected in patterns of metabolism and behavior.
Zhijun Zhang, Shuo Wang, Ling Gao
doaj   +1 more source

Squash silverleaf disorder and whitefly (Bemisia tabaci MEAM1) infestation: Implications for plant disease management in a changing climate

Annals of Applied Biology, Volume 189, Issue 2, September 2026.
Squash Silverleaf Disorder (SLD) is growing in its economic impact due to the invasive behaviour of the silverleaf whitefly (Bemisia tabaci MEAM1). In this review we summarize what is currently known about the whitefly‐squash interaction, how both the disease and the whitefly are being affected by climate change, and discuss current and novel ...
Nihal Oztolan‐Erol, Yusuf Sen, Melike Cokol‐Cakmak, Guler Demirbas‐Uzel, Stuart J. Lucas   +4 more
wiley   +1 more source

Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes

Journal of Diabetes
As a sensor, glucokinase (GK) controls glucose homeostasis, which progressively declines in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the homeostatic system set points.
Ping Li, Dalong Zhu
doaj   +1 more source

Ontogenic Profile of Hexokinase and Glucokinase mRNA Expressions in Embryonic Chicken Liver and Muscle

The Journal of Poultry Science, 2013
The present study describes ontogenic profile of mRNA expressions of hexokinase (HK; EC 2.7.1.1) and glucokinase (GK; EC 2.7.1.2, otherwise known as HKIV) that catalyze the first step of glucose metabolism by cells.
Tushar K. Roy, Atsushi Iwasawa, Yasutake Shimizu, Koji Kageyama, Norio Yoshizaki   +4 more
doaj   +1 more source