Results 101 to 110 of about 21,204 (221)

Effect of Cyclocarya paliurus on Glucose Metabolism and Intestinal GLP-1 Secretion in Type 2 Diabetic Rats

Shipin gongye ke-ji
Objective: This study aimed to evaluate the hypoglycemic effect of Cyclocarya paliurus on type 2 diabetic rats and its impact on glucagon-like peptide-1 (GLP-1) secretion, and to preliminarily explore its mechanism.
Yaqian ZOU, Liang CHEN, Jia MU, Yajing WANG, Xumeng CHEN   +4 more
doaj   +1 more source

Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)

Сахарный диабет, 2019
An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019)
Natalia A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasilyev, Vasily M. Petrov, Anatoly N. Tiulpakov   +7 more
doaj   +1 more source

Apparent starvation-induced repression of pancreatic islet glucokinase

, 1995
Conflicting data were previously reported concerning the effect of starvation upon the glucokinase protein and glucokinase mRNA content of pancreatic islets. In the present study, conducted in fed rats and animals starved for 48 h, the catalytic activity
Gomis, Ramon, Sener, Abdullah, Gasa, Rosa, Malaisse, Willy   +3 more
core   +1 more source

The regulatory protein of liver glucokinase.

, 1992
Fructose, sorbitol and D-glyceraldehyde stimulate the rate of glucose phosphorylation in isolated hepatocytes. This effect is mediated by fructose 1-phosphate, which releases the inhibition exerted by a regulatory protein on liver glucokinase.
Vandercammen, A., Detheux, Michel, Van Schaftingen, Emile, Davies, D R   +3 more
core  

Liver-specific enhancer of the glucokinase gene.

, 1996
Glucokinase gene regions that are important for liver specific expression of the enzyme have been functionally identified using transient transfection of rat hepatocytes.
Marie S, Nazaryan K, Gjinovci A, Iynedjian PB, Wang H   +4 more
core   +1 more source

Glucokinase of rabbit liver: purification and properties

, 1965
It has been recently shown that in rat liver there are two enzymes which phosphorylate glucose to glucose 6-phosphate. One o f them is a hexokinase with a great af f ini ty for glucose and, like those o f other ...
Sols, Alberto, Viñuela, Eladio, Salas, Margarita, Salas, José   +3 more
core   +1 more source

Integrative clinicogenomic analysis of the monoallelic pathogenic substitution p.Thr228Met in the GCK gene as a nosological marker of type 3 diabetes (MODY 2) with a phenotype of moderate stable hyperglycemia and preserved β-cell secretory capacity

Клинический разбор в общей медицине
Monogenic forms of diabetes mellitus, collectively classified as MODY (Maturity Onset Diabetes of the Young), represent rare, genetically determined variants of the disease with an autosomal dominant inheritance pattern, typically manifesting at a young ...
Svyatoslav M. Yurin, Dmitry A. Apalkov, Tatiana A. Minenkova, Natalia S. Razinkova, Alexandra V. Serezhkina   +4 more
doaj   +1 more source

TAT-PBX1 Reverses Hyperglycemia Through β-Cell Regeneration and Functional Restoration in an STZ-Induced Diabetic Model

Pharmaceuticals
Objective: β-cell dysfunction and loss are major pathological determinants of impaired islet function and hyperglycemia in diabetes. Given the inability of current therapies to restore β-cell viability or glucose-responsive insulin secretion, this study ...
Xiangyuan Meng, Zhenhu Zhao, Xin Zhang, Ruihan Guo, Shuran Yang, Shuhua Mao, Ziyu Zong, Jinyu Liu   +7 more
doaj   +1 more source

Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein

, 2016
The glucokinase regulatory protein (GKRP) is a competitive inhibitor of glucokinase (GCK), triggering its localization to the hepatocyte nucleus upon glucose deprivation. Here we establish the kinetic mechanism of GKRP action by analyzing its association
Brian G. Miller (110045), Ashley K. Casey (1318440)   +1 more
core   +1 more source

Structure–Activity Relationship of Azaindole-Based Glucokinase Activators

, 2016
7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with ...
András Kotschy (1417294), Alain Ktorza (52710), Attila Paczal (1417285), Zoltán B. Szabó (1417297), Frédéric De Ceuninck (1417306), Balázs Bálint (1417288), Levente Ondi (1417303), Isabelle Theret (1417282), Catherine Bernard (657268), Francoise Perron-Sierra (1417300), Csaba Wéber (1417291)   +10 more
core   +1 more source