Results 101 to 110 of about 31,450 (226)

A synonymous variant in GCK gene as a cause of gestational diabetes mellitus

Сахарный диабет, 2019
The diagnosis of MODY as a subtype of gestational diabetes mellitus (GDM) is important for an adequate management during pregnancy and the postnatal period.
Natalia A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasilyev, Vasily M. Petrov, Anatoly N. Tiulpakov   +7 more
doaj   +1 more source

Personalized Prognosis and Diagnosis of Type 2 Diabetes - Vision or Fiction? [PDF]

, 2010
Typical civilization diseases, such as type 2 diabetes, share several features: their worldwide frequency, the complexity of the underlying pathogenic mechanisms, heterogeneity in the phenotypes and their multifactorial nature due to a wide variety of ...
Mueller, Guenter
core   +1 more source

Morning glucagon disrupts insulin induced hepatic metabolic memory and subsequent afternoon glucose metabolism in canines

Frontiers in Endocrinology
IntroductionThe Staub-Traugott effect, or second-meal phenomenon, describes improved glucose disposal after a second identical meal. We previously showed that morning hyperinsulinemia primes the liver to enhance afternoon net hepatic glucose uptake and ...
Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey, Karin J. Bosma, Richard M. O’Brien, Derek P. Claxton, Tristan Howard, Guillaume Kraft, Alan D. Cherrington, Dale S. Edgerton   +10 more
doaj   +1 more source

Sapium ellipticum (Hochst) Pax ethanol leaf extract modulates glucokinase and glucose-6-phosphatase activities in streptozotocin induced diabetic rats

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To examine the effects of Sapium ellipticum (SE) leaf extract on the hepatic activities of glucokinase and glucose-6-phosphatase in streptozotocin-induced diabetic Wistar rats.
Osasenaga Macdonald Ighodaro, Oluseyi Adeboye Akinloye, Regina Ngozi Ugbaja, Samuel Olatunbosun Omotainse   +3 more
doaj   +1 more source

New Solutions in Single-Cell Protein Production from Methane: Construction of Glycogen-Deficient Mutants of Methylococcus capsulatus MIR

Fermentation
The biotechnology of converting methane to single-cell protein (SCP) implies using fast-growing thermotolerant aerobic methanotrophic bacteria. Among the latter, members of the genus Methylococcus received significant research attention and are used in ...
Sergey Y. But, Ruslan Z. Suleimanov, Igor Y. Oshkin, Olga N. Rozova, Ildar I. Mustakhimov, Nikolai V. Pimenov, Svetlana N. Dedysh, Valentina N. Khmelenina   +7 more
doaj   +1 more source

Case Report: New insights about clinical manifestations of patients with GCK genetic variants

Frontiers in Endocrinology
GCK-MODY is a genetic condition characterized by alterations in the GCK gene, which can include several types of inactivating genetic variants - ranging from missense and nonsense variants, and splice site variants, to small and large deletions and ...
Ritiele Bastos de Souza, Gabriella de Medeiros Abreu, Gabriella de Medeiros Abreu, Marília Chaves Bernardo, Roberta Magalhães Tarantino, Melanie Rodacki, Lenita Zajdenverg, Amanda Ferreira de Andrade, Deborah Snaider Nicolay, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Renata Szundy Berardo, Jorge Luiz Luescher, Verônica Marques Zembrzuski, Pedro Hernan Cabello, Mario Campos Junior   +19 more
doaj   +1 more source

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood [PDF]

, 1973
The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has ...
Brown, TH, Francavilla, A, Francavilla, FR, Halgrimson, CG, Porter, KA, Putnam, CW, Starzl, TE   +6 more
core  

Effect of Cyclocarya paliurus on Glucose Metabolism and Intestinal GLP-1 Secretion in Type 2 Diabetic Rats

Shipin gongye ke-ji
Objective: This study aimed to evaluate the hypoglycemic effect of Cyclocarya paliurus on type 2 diabetic rats and its impact on glucagon-like peptide-1 (GLP-1) secretion, and to preliminarily explore its mechanism.
Yaqian ZOU, Liang CHEN, Jia MU, Yajing WANG, Xumeng CHEN   +4 more
doaj   +1 more source

Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)

Сахарный диабет, 2019
An erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019)
Natalia A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasilyev, Vasily M. Petrov, Anatoly N. Tiulpakov   +7 more
doaj   +1 more source

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells [PDF]

, 2018
Aims/hypothesis: Mutations in genes encoding HNF-4α, HNF-1α and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3 and -4. Impaired glucose-stimulated insulin secretion is the common primary defect of these monogenic forms of diabetes.
Antinozzi, P., Gauthier, B., Halban, P., Iezzi, M., Theander, S., Wang, H., Wollheim, C.   +6 more
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