Results 1 to 10 of about 51,644 (167)

Hepatitis C Virus (HCV)—Mediated Activation of Hexokinase Domain-Containing Protein 1 (HKDC1) Promotes Hexokinase Activity and Metabolic Reprogramming [PDF]

Viruses
Hepatitis C virus (HCV) infection is a significant contributor to the development of hepatocellular carcinoma (HCC). One mechanism by which HCV promotes HCC is the remodeling of host cell metabolism; however, the molecular mediators of this process are ...
Hope K. Fiadjoe, Amani Doyle, In-Woo Park, Pankaj Chaudhary   +3 more
doaj   +2 more sources

IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY

Berkala Kedokteran, 2022
: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative
Ellen Ayuningtyas Pratidina, Eko Suhartono, Bambang Setiawan   +2 more
doaj   +1 more source

Hexokinase1: A glucose sensor involved in drought stress response and sugar metabolism depending on its kinase activity in strawberry

Frontiers in Plant Science, 2023
Hexokinase1 (HXK1) is a bifunctional enzyme that plays indispensable roles in plant growth, nitrogen utilization, and stress resistance. However, information on the HXK family members of strawberries and their functions in glucose sensing and metabolic ...
Runqin Wu, Ximeng Lin, Jinwei He, Ailing Min, Li Pang, Yan Wang, Yuanxiu Lin, Yunting Zhang, Wen He, Mengyao Li, Yong Zhang, Ya Luo, Xiaorong Wang, Haoru Tang, Qing Chen   +14 more
doaj   +1 more source

The hexokinase Gene Family in Cotton: Genome-Wide Characterization and Bioinformatics Analysis

Frontiers in Plant Science, 2022
Hexokinase (HXK) is involved in hexose phosphorylation, sugar sensing, and signal transduction, all of which regulate plant growth and adaptation to stresses. Gossypium hirsutum L. is one of the most important fiber crops in the world, however, little is
Lingling Dou, Zihan Li, Huiqin Wang, HuaiZhu Li, Guanghui Xiao, Xianliang Zhang   +5 more
doaj   +1 more source

Genome-Wide Characterization of Soybean Hexokinase Genes Reveals a Positive Role of GmHXK15 in Alkali Stress Response

Plants, 2023
Hexokinase (HXK) proteins catalyze hexose phosphorylation and are important for the sensing and signaling of sugar. In order to determine the roles played by HXKs in soybean growth and stress responsiveness, seventeen HXK genes (GmHXK1-17) were isolated ...
Feng Jiao, Yang Chen, Dongdong Zhang, Jinhua Wu   +3 more
doaj   +1 more source

Hexokinases and cardioprotection [PDF]

Journal of Molecular and Cellular Cardiology, 2015
As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of ...
Calmettes, Guillaume, Ribalet, Bernard, John, Scott, Korge, Paavo, Ping, Peipei, Weiss, James N   +5 more
openaire   +4 more sources

Promoting the Synthesis of Precursor Substances by Overexpressing Hexokinase (Hxk) and Hydroxymethylglutaryl-CoA Synthase (Erg13) to Elevate β-Carotene Production in Engineered Yarrowia lipolytica

Frontiers in Microbiology, 2020
As a valuable carotenoid, β-carotene is commercially used in food, cosmetics, animal feeds, and other industries. Metabolic engineering of microorganisms has been widely explored to improve the production of β-carotene.
Shan Qiang, Shan Qiang, Shan Qiang, Shan Qiang, Jing Wang, Jing Wang, Jing Wang, Xiao Chao Xiong, Yu Ling Qu, Yu Ling Qu, Yu Ling Qu, Liang Liu, Liang Liu, Liang Liu, Ching Yuan Hu, Ching Yuan Hu, Ching Yuan Hu, Ching Yuan Hu, Yong Hong Meng, Yong Hong Meng, Yong Hong Meng   +20 more
doaj   +1 more source

Altered oxidative stress and carbohydrate metabolism in canine mammary tumors [PDF]

Veterinary World, 2016
Aim: Mammary tumors are the most prevalent type of neoplasms in canines. Even though cancer induced metabolic alterations are well established, the clinical data describing the metabolic profiles of animal tumors is not available.
K. Jayasri, K. Padmaja, M. Saibaba
doaj   +1 more source

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. [PDF]

PLoS ONE, 2008
Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis.
Federica Chiara, Diego Castellaro, Oriano Marin, Valeria Petronilli, William S Brusilow, Magdalena Juhaszova, Steven J Sollott, Michael Forte, Paolo Bernardi, Andrea Rasola   +9 more
doaj   +1 more source

Small Hexokinase 1 Peptide against Toxic SOD1 G93A Mitochondrial Accumulation in ALS Rescues the ATP-Related Respiration

Biomedicines, 2021
Mutations in Cu/Zn Superoxide Dismutase (SOD1) gene represent one of the most common causes of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder that specifically affects motor neurons (MNs). The dismutase-active SOD1 G93A mutant is
Andrea Magrì, Pierpaolo Risiglione, Antonella Caccamo, Beatrice Formicola, Marianna Flora Tomasello, Cristina Arrigoni, Stefania Zimbone, Francesca Guarino, Francesca Re, Angela Messina   +9 more
doaj   +1 more source