Results 41 to 50 of about 59,802 (286)
Decreased hexokinase activity at early stage in female aging.
, 2013 A. In nonTg hippocampus, expression of hexokinase 2 decreased significantly at 15 months of age. B. Hexokinase activity in nonTg hippocampus decreased significantly after 6 months of age. C. There was no change in the expression of hexokinase 2 in 3xTgAD
Jamaica R. Rettberg (482780) +4 more
core +1 more source
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
Advanced Science, EarlyView.This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang +7 more
wiley +1 more source
Genome-Wide Survey and Expression Analyses of Hexokinase Family in Poplar (Populus trichocarpa)
Plants, 2022 Hexokinase (HXK) family proteins exert critical roles in catalyzing hexose phosphorylation, sugar sensing, and modulation of plant growth and stress adaptation.
Mei Han +7 more
doaj +1 more source
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
Research progress on the mechanism of glycolysis in ovarian cancer
Frontiers in Immunology, 2023 Glycolysis is the preferred energy metabolism pathway in cancer cells even when the oxygen content is sufficient. Through glycolysis, cancer cells convert glucose into pyruvic acid and then lactate to rapidly produce energy and promote cancer progression.
Chan Li +5 more
doaj +1 more source
Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase.
, 2002 For Trypanosoma brucei, a parasite responsible for African sleeping sickness, carbohydrate metabolism is the only source of ATP, and glycolytic enzymes are localized within membrane-bound organelles called glycosomes.
Sanejouand, Yves Henri +4 more
core +1 more source
Advanced Science, EarlyView.Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu +20 more
wiley +1 more source
Studies on Brain Hexokinase. Part Ⅰ. On hexokinase in the cerebral cortex of rabbits [PDF]
, 1959 The hexokinase activity in the cerebral cortex of normal rabbits was measured by Longs method and the influences of fluoride, Ca ion, glutamic acid, glutamine, aspartic acid, asparagine, γ-aminobutyric acid and α-ketoglutaric acid upon the hexokinase ...
Yamada, Takahiko
core
On the InterAktion between Hexokinase and the Mitochondrion
, 2004 The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the ...
Birnbaum, Morris J.
core +1 more source
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source