Results 61 to 70 of about 59,802 (286)
Cancer Cell International, 2020 Background Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. Targeting cancer cells’ metabolism is a promising strategy in inhibiting cancer cell progression. We used D-Mannoheptulose, a specific
Ahmed Ghdhban Al-Ziaydi +4 more
doaj +1 more source
Human hexokinase: multiple mechanisms of G6P inhibition
, 2001 Human hexokinase I catalyzes the first step in glycolysis, playing a key role in the energy metabolism of brain tissue. The chapters included in this thesis focus on structure-function relationships of hexokinase I.
Liu, Xiaofeng
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Hexokinase and carnitine palmitoyltransferase activities in flight muscles of grasshopper Valanga nigricornis(burm.) [PDF]
, 1983 1. The activities of hexokinase and carnitine palmitoyltransferase (CPT) activities were assayed in flight muscle mitochondria of Valanga nigricornis. 2. Kinetic analysis of the enzyme activities yielded the following information: for hexokinase, its Km (
Lee, C. W., Tan, C. H.
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Advanced Science, EarlyView.This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang +17 more
wiley +1 more source
eLife, 2019 Human MondoA requires glucose as well as other modulatory signals to function in transcription. One such signal is acidosis, which increases MondoA activity and also drives a protective gene signature in breast cancer.
Blake R Wilde +3 more
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Mitochondrial VDAC and hexokinase together modulate plant programmed cell death
, 2013 The voltage-dependent anion channel (VDAC) and mitochondrially located hexokinase have been implicated both in pathways leading to cell death on the one hand, and immortalization in tumor formation on the other.
Udayakumar, M. +4 more
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Oncotarget, 2013 It is well established that cancer cells differ from most somatic adult cells by their high rate of aerobic glycolysis despite oxidative phosphorylation. This distinct property of cancer cells is often used for tumor imaging in vivo following the administration of the labeled glucose analog, fluoro deoxy glucose (FDG).
Krushna C, Patra, Nissim, Hay
openaire +2 more sources
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
In vitro synthesis of rat brain hexokinase.
, 1985 Hexokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) has been synthesized in the rabbit reticulocyte lysate system directed by poly(A)+ mRNA isolated from rat brain. Identification of the in vitro synthesis product as hexokinase was based on its
Wilson, J E, Kozak, L P, Pittler, S J
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Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source