Results 71 to 80 of about 59,802 (286)
Advanced Science, EarlyView.Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang +16 more
wiley +1 more source
Effect of phytohormones on tissue hexokinase and on some blood components in wistar rats [PDF]
, 2011 Dietary phytohormones may influence the metabolic processes in animal cells. To determine the effect of the plant growth regulators 28-homobrassinolide, gibberellic acid and kinetin on the tissue hexokinase and some blood components in male rats. Methods:
Muthuraman, P.; Dept. of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Kalapet, Puducherry-605014, India. +4 more
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Advanced Science, EarlyView.Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu +9 more
wiley +1 more source
Advanced Science, EarlyView.LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao +12 more
wiley +1 more source
IUCrJ, 2020 Malaria is a devastating disease caused by a protozoan parasite. It affects over 300 million individuals and results in over 400 000 deaths annually, most of whom are young children under the age of five.
Shanti Swaroop Srivastava +5 more
doaj +1 more source
Advanced Science, EarlyView.HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu +12 more
wiley +1 more source
Purification and Characterization of Ascaris Suum Hexokinase [PDF]
, 1975 Hexokinase has been found in a soluble and a bound form in homogenates of Ascaris suum muscle. Cellulose acetate electrophoresis, isoelectric focusing, and ion exchange chromatography confirmed the presence of only one molecular form of hexokinase in ...
Supowit, Scott C.
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The structure and function of human brain hexokinase
, 1996 An ATP binding site model for human brain hexokinase was established based on the similarity of the ATP-binding domains among actin, heat shock protein, glycerol kinase and brain hexokinase.
Zeng, Chenbo
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Advanced Science, EarlyView.A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong +9 more
wiley +1 more source