Results 91 to 100 of about 59,802 (286)

Batch‐to‐Batch Optimization of pH Shifts in CHO Bioreactor Operations

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Culture pH is an important operating parameter in CHO cell cultures producing mAb since it directly affects growth and specific productivity. Mathematical models can be used to optimize the magnitude and timing of pH shifts provided that they are robust to model errors.
Ali Ghodba   +6 more
wiley   +1 more source

Metabolic modulation of hexokinase association with mitochondria in living smooth muscle cells

open access: yes, 1996
Hexokinase isoform I binds to mitochondria of many cell types. It has been hypothesized that this association is regulated by changes in the concentrations of specific cellular metabolites.
K. E. Fogarty   +3 more
core   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

open access: yesBMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu   +10 more
wiley   +1 more source

A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates [PDF]

open access: yes, 1992
Mammalian hexokinase type I is a 100 kDa enzyme that has been considered to be evolved from an ancestral 50 kDa yeast-type hexokinase, insensitive to product inhibition, by gene duplication and fusion.
MAGNANI M   +12 more
core   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

open access: yesChemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi   +6 more
wiley   +1 more source

Using Positron Emission Tomography with [18F]FDG to Predict Tumor Behavior in Experimental Colorectal Cancer

open access: yesNeoplasia: An International Journal for Oncology Research, 2001
This study investigates the relationship between FDG uptake as determined by positron emission tomography (PET) imaging and rates of tumor growth, cellular GLUT1 transporter density, and the activities of hexokinase and glucose-6-phosphatase in a solid ...
Bryan M. Burt   +6 more
doaj   +1 more source

Hexokinase activity in activated T cells is regulated by MAPK signaling.

open access: yes, 2013
(A) T cells were stimulated in the absence or presence of the ERK inhibitor U0126 (2.6 µM), as in Figure 3, and hexokinase activity was measured ...
Alina Kelman (359987)   +3 more
core   +1 more source

Hexokinase isozyme variability in Drosophila robusta [PDF]

open access: yes, 1969
Several isozymes of hexokinase have been found in Drosophila robusta . These have been defined in this paper in several dimensions, including genetic variation, ontogenic variation, tissue-organ variation, and substrate specificity.Peer Reviewedhttp ...
Knutsen, Conrad A.   +2 more
core   +1 more source

Antioxidant Activity, Carbohydrate‐Hydrolysing Enzyme Inhibition, Antihyperglycaemic Effect and Associated Expression Changes of Bryophyllum pinnatum‐Fortified Wheat‐Plantain Snack in Streptozotocin‐Induced Diabetic Rats

open access: yesFood Chemistry International, EarlyView.
The developed wheat‐plantain‐based snack with Bryophyllum pinnatum had enhanced antioxidant properties, with high α‐amylase and α‐glucosidase enzyme inhibitory activities. When fed to STZ‐induced diabetic rats, it showed antidiabetic, hypo‐lipidaemic and anti‐inflammatory potentials, thus making it a fresh opportunity for the snacking community who are
G. M. Ogungbenro   +6 more
wiley   +1 more source

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