Results 101 to 110 of about 58,740 (306)

Red blood cell loading with hexokinase and hexokinase-inactivating antibodies. A new strategy for studying the role of enzymes in red cell metabolism and removal

open access: yes, 1990
Human erythrocytes were loaded with homogeneous hexokinase purified from human placenta or with inactivating anti hexokinase IgG, using a procedure of encapsulation based on hypotonic hemolysis, isotonic resealing and reannealing.
ROSSI, LUIGIA   +4 more
core   +1 more source

T cell activation induces hexokinase activity.

open access: yes, 2013
(A) Resting or 24-hour stimulated T cells were lysed in 0.1% Triton X-100 and enzymatic activity of hexokinase was measured ...
Alina Kelman (359987)   +3 more
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

open access: yesiNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid   +4 more
wiley   +1 more source

Anomeric specificity of mannose phosphorylation by hexokinase

open access: yes, 1985
In rat parotid or pancreatic islet homogenates incubated at 7° C, hexokinase displayed a greater affinity for but a lower maximal velocity with the α-anomer, as distinct from β-anomer, of D-mannose.
Sener, Abdullah   +2 more
core   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu   +7 more
wiley   +1 more source

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans

open access: yesFrontiers in Microbiology, 2019
The pathogenic yeast Candida albicans is both a powerful commensal and a pathogen of humans that can infect wide range of organs and body sites. Metabolic flexibility promotes infection and commensal colonization by this opportunistic pathogen.
Romain Laurian   +6 more
doaj   +1 more source

Subcellular localization of rice hexokinase (OsHXK) family members in the mesophyll protoplasts of tobacco

open access: yes, 2011
Hexokinase (HXK, EC 2.7.1.1) plays an important role in the metabolism and glucose signalling. To examine the characteristics of HXK gene family in rice, the subcellular localizations of ten hexokinases (OsHXK1 - OsHXK10) were determined using OsHXK::GFP
W. Cheng   +7 more
core   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang   +3 more
wiley   +1 more source

Substrate specificity of glucokinase and fructokinase of several conifer species

open access: yesActa Societatis Botanicorum Poloniae, 2014
Annual plant species were found to have several distinct classes of hexokinases which are specific for different hexoses, such as glucose, fructose and mannose.
Fritz Bergmanni, Leon Mejnartowicz
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

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