Results 51 to 60 of about 58,740 (306)
Human hexokinase: multiple mechanisms of G6P inhibition
, 2001 Human hexokinase I catalyzes the first step in glycolysis, playing a key role in the energy metabolism of brain tissue. The chapters included in this thesis focus on structure-function relationships of hexokinase I.
Liu, Xiaofeng
core +1 more source
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
Advanced Science, EarlyView.This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang +7 more
wiley +1 more source
Product Inhibition of the Hexokinases
Journal of Biological Chemistry, 1970 ADP3- and ADPMg caused mixed inhibition of purified yeast hexokinase isoenzymes and ascites tumor hexokinases I and II when ATPMg is the varied substrate. Since exchange between ADPMg and ATPMg is observed under steady state conditions in which free glucose-6-P is not available for reaction, the effect of ADPMg on Vmax must result from its reaction at ...
D P, Kosow, I A, Rose
openaire +2 more sources
Studies on Brain Hexokinase. Part Ⅰ. On hexokinase in the cerebral cortex of rabbits [PDF]
, 1959 The hexokinase activity in the cerebral cortex of normal rabbits was measured by Longs method and the influences of fluoride, Ca ion, glutamic acid, glutamine, aspartic acid, asparagine, γ-aminobutyric acid and α-ketoglutaric acid upon the hexokinase ...
Yamada, Takahiko
core
, 1998 Hexokinase I, the pacemaker of glycolysis in brain tissue and red blood cells, is comprised of two similar domains fused into a single polypeptide chain.
Honzatko, Richard B +4 more
core +1 more source
Mitochondrial hexokinase and cardioprotection of the intact heart [PDF]
, 2009 The interaction of hexokinase with mitochondria has emerged as a powerful mechanism in protecting many cell types against cell death. However, the role of mitochondrial hexokinase (mitoHK) in cardiac ischemia-reperfusion injury has as of yet received ...
Smeele, K. M. A. +7 more
core +2 more sources
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
Frontiers in Immunology, 2017 At the beginning of the twentieth century, discoveries in cancer research began to elucidate the idiosyncratic metabolic proclivities of tumor cells (1).
Scott M. Seki +3 more
doaj +1 more source
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
Cancer Cell International, 2020 Background Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. Targeting cancer cells’ metabolism is a promising strategy in inhibiting cancer cell progression. We used D-Mannoheptulose, a specific
Ahmed Ghdhban Al-Ziaydi +4 more
doaj +1 more source